8JPD
 
 | | Focused refinement structure of GRK2 in NTSR1-GRK2-Galpha(q) complexes | | 分子名称: | Beta-adrenergic receptor kinase 1, STAUROSPORINE | | 著者 | Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. | | 登録日 | 2023-06-11 | | 公開日 | 2023-08-09 | | 最終更新日 | 2023-08-30 | | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | | 主引用文献 | GPCR activation and GRK2 assembly by a biased intracellular agonist.
Nature, 620, 2023
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8JPB
 | | cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 1 | | 分子名称: | 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Beta-adrenergic receptor kinase 1, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. | | 登録日 | 2023-06-11 | | 公開日 | 2023-08-09 | | 最終更新日 | 2023-08-30 | | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | | 主引用文献 | GPCR activation and GRK2 assembly by a biased intracellular agonist.
Nature, 620, 2023
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8JPE
 | | Focused refinement structure of Galpha(q) in NTSR1-GRK2-Galpha(q) complexes | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(q) subunit alpha, MAGNESIUM ION, ... | | 著者 | Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. | | 登録日 | 2023-06-11 | | 公開日 | 2023-08-09 | | 最終更新日 | 2023-08-30 | | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | | 主引用文献 | GPCR activation and GRK2 assembly by a biased intracellular agonist.
Nature, 620, 2023
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8JPF
 | | Focused refiment structure of NTSR1 in NTSR1-GRK2-Galpha(q) complexes | | 分子名称: | 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, NTS, Neurotensin receptor type 1 | | 著者 | Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. | | 登録日 | 2023-06-11 | | 公開日 | 2023-08-09 | | 最終更新日 | 2023-08-30 | | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | | 主引用文献 | GPCR activation and GRK2 assembly by a biased intracellular agonist.
Nature, 620, 2023
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8F2F
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8H8J
 | | Lodoxamide-bound GPR35 in complex with G13 | | 分子名称: | 2,2'-[(2-chloro-5-cyano-1,3-phenylene)bis(azanediyl)]bis(oxoacetic acid), CALCIUM ION, CHOLESTEROL, ... | | 著者 | Yuan, Q, Duan, J, Liu, Q, Xu, H.E, Jiang, Y. | | 登録日 | 2022-10-23 | | 公開日 | 2023-02-08 | | 最終更新日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Insights into divalent cation regulation and G 13 -coupling of orphan receptor GPR35.
Cell Discov, 8, 2022
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8HCX
 | | Cryo-EM structure of Endothelin1-bound ETBR-Gq complex | | 分子名称: | Endothelin receptor type B,Oplophorus-luciferin 2-monooxygenase catalytic subunit chimera, Endothelin-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Yuan, Q, Jiang, Y, Xu, H.E, Ji, Y, Duan, J. | | 登録日 | 2022-11-03 | | 公開日 | 2023-03-22 | | 最終更新日 | 2023-10-04 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural basis of peptide recognition and activation of endothelin receptors.
Nat Commun, 14, 2023
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8HBD
 | | Cryo-EM structure of IRL1620-bound ETBR-Gi complex | | 分子名称: | Endothelin receptor type B,Endothelin receptor type B,Oplophorus-luciferin 2-monooxygenase catalytic subunit chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Yuan, Q, Ji, Y, Jiang, Y, Duan, J, Xu, H.E. | | 登録日 | 2022-10-28 | | 公開日 | 2023-03-22 | | 最終更新日 | 2023-10-04 | | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | | 主引用文献 | Structural basis of peptide recognition and activation of endothelin receptors.
Nat Commun, 14, 2023
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8HCQ
 | | Cryo-EM structure of endothelin1-bound ETAR-Gq complex | | 分子名称: | Endothelin-1, Endothelin-1 receptor,Oplophorus-luciferin 2-monooxygenase catalytic subunit chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Yuan, Q, Jiang, Y, Xu, H.E, Ji, Y, Duan, J. | | 登録日 | 2022-11-02 | | 公開日 | 2023-03-22 | | 最終更新日 | 2023-10-04 | | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | | 主引用文献 | Structural basis of peptide recognition and activation of endothelin receptors.
Nat Commun, 14, 2023
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5D9E
 | | Crystal Structure of the Proline-rich Lasso Peptide Caulosegnin II | | 分子名称: | CHLORIDE ION, Caulosegnin II | | 著者 | Fage, C.D, Hegemann, J.D, Harms, K, Marahiel, M.A. | | 登録日 | 2015-08-18 | | 公開日 | 2016-02-17 | | 最終更新日 | 2019-05-08 | | 実験手法 | X-RAY DIFFRACTION (0.859 Å) | | 主引用文献 | The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II.
Mol Biosyst, 12, 2016
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6LNM
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6M02
 | | cryo-EM structure of human Pannexin 1 channel | | 分子名称: | Pannexin-1 | | 著者 | Ronggui, Q, Lili, D, Jilin, Z, Xuekui, Y, Lei, W, Shujia, Z. | | 登録日 | 2020-02-19 | | 公開日 | 2020-03-25 | | 最終更新日 | 2020-05-27 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cryo-EM structure of human heptameric Pannexin 1 channel.
Cell Res., 30, 2020
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7VRA
 | | The crystal structure of EGFR T790M/C797S with the inhibitor HC5476 | | 分子名称: | 25-chloro-11-(ethylsulfonyl)-44-morpholino-11H-5,12-dioxa-3-aza-1(3,6)-indola-2(4,2)-pyrimidina-4(1,3)-benzenacyclododecaphane, Epidermal growth factor receptor | | 著者 | Zhu, S.J. | | 登録日 | 2021-10-22 | | 公開日 | 2022-06-08 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations.
J.Med.Chem., 65, 2022
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7VRE
 | | The crystal structure of EGFR T790M/C797S with the inhibitor HCD2892 | | 分子名称: | 5-chloranyl-N-[5-chloranyl-2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-(1-ethylsulfonylindol-3-yl)pyrimidin-2-amine, Epidermal growth factor receptor | | 著者 | Zhu, S.J. | | 登録日 | 2021-10-22 | | 公開日 | 2022-06-08 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.507 Å) | | 主引用文献 | Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations.
J.Med.Chem., 65, 2022
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7YFM
 | | Structure of GluN1b-GluN2D NMDA receptor in complex with agonists glycine and glutamate. | | 分子名称: | Glutamate receptor ionotropic, NMDA 2D, Isoform 6 of Glutamate receptor ionotropic, ... | | 著者 | Zhang, J.L, Zhu, S.J, Zhang, M. | | 登録日 | 2022-07-08 | | 公開日 | 2023-03-29 | | 最終更新日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (5.1 Å) | | 主引用文献 | Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits.
Nat.Struct.Mol.Biol., 30, 2023
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7YFO
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7YFL
 | | Structure of GluN1a-GluN2D NMDA receptor in complex with agonists glycine and glutamate. | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ... | | 著者 | Zhang, J.L, Zhu, S.J, Zhang, M. | | 登録日 | 2022-07-08 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits.
Nat.Struct.Mol.Biol., 30, 2023
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7YFR
 | | Structure of GluN1a E698C-GluN2D NMDA receptor in cystines non-crosslinked state. | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ... | | 著者 | Zhang, J.L, Zhu, S.J, Zhang, M. | | 登録日 | 2022-07-09 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (5.1 Å) | | 主引用文献 | Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits.
Nat.Struct.Mol.Biol., 30, 2023
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7YFF
 | | Structure of GluN1a-GluN2D NMDA receptor in complex with agonist glycine and competitive antagonist CPP. | | 分子名称: | (2R)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhang, J.L, Zhu, S.J, Zhang, M. | | 登録日 | 2022-07-08 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits.
Nat.Struct.Mol.Biol., 30, 2023
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5UTT
 | | SrtA sortase from Actinomyces oris | | 分子名称: | CHLORIDE ION, Sortase | | 著者 | Osipiuk, J, Ma, X, Ton-That, H, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2017-02-15 | | 公開日 | 2017-03-01 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Cell-to-cell interaction requires optimal positioning of a pilus tip adhesin modulated by gram-positive transpeptidase enzymes.
Proc.Natl.Acad.Sci.USA, 116, 2019
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6ILW
 | | Crystal structure of PETase from Ideonella sakaiensis | | 分子名称: | CHLORIDE ION, Poly(ethylene terephthalate) hydrolase, SODIUM ION | | 著者 | Liu, C.C, Shi, C. | | 登録日 | 2018-10-19 | | 公開日 | 2019-03-27 | | 最終更新日 | 2020-09-09 | | 実験手法 | X-RAY DIFFRACTION (1.575 Å) | | 主引用文献 | Structural and functional characterization of polyethylene terephthalate hydrolase from Ideonella sakaiensis.
Biochem. Biophys. Res. Commun., 508, 2019
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6ILX
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8JJ2
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8JJ1
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8JIZ
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