4CDQ
 
 | | Crystal structure of human Enterovirus 71 in complex with the uncoating inhibitor GPP2 | | 分子名称: | 4-((5-(2-oxo-3-(pyridin-4-yl)imidazolidin-1-yl)pentyl)oxy)benzaldehyde O-ethyl oxime, SODIUM ION, VP1, ... | | 著者 | DeColibus, L, Wang, X, Spyrou, J.A.B, Kelly, J, Ren, J, Grimes, J, Puerstinger, G, Stonehouse, N, Walter, T.S, Hu, Z, Wang, J, Li, X, Peng, W, Rowlands, D, Fry, E.E, Rao, Z, Stuart, D.I. | | 登録日 | 2013-11-05 | | 公開日 | 2014-02-12 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | More-Powerful Virus Inhibitors from Structure-Based Analysis of Hev71 Capsid-Binding Molecules
Nat.Struct.Mol.Biol., 21, 2014
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4YDV
 | | STRUCTURE OF THE ANTIBODY 7B2 THAT CAPTURES HIV-1 VIRIONS | | 分子名称: | HIV ANTIBODY 7B2 HEAVY CHAIN,IgG H chain, HIV ANTIBODY 7B2 LIGHT CHAIN,Ig kappa chain C region, HIV GP41 PEPTIDE GP41(596-606) | | 著者 | Nicely, N.I, Pemble IV, C.W. | | 登録日 | 2015-02-23 | | 公開日 | 2015-08-12 | | 最終更新日 | 2021-03-24 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques.
Plos Pathog., 11, 2015
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5KG9
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6OQI
 | | CDK2 in complex with Cpd14 (5-fluoro-4-(4-methyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-3-yl)-N-(5-(4-methylpiperazin-1-yl)pyridin-2-yl)pyrimidin-2-amine) | | 分子名称: | 5-fluoro-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]-4-[(4S)-4-methyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-3-yl]pyrimidin-2-amine, Cyclin-dependent kinase 2 | | 著者 | Murray, J.M. | | 登録日 | 2019-04-26 | | 公開日 | 2020-07-29 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma.
Bioorg.Med.Chem.Lett., 29, 2019
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6U6O
 | | Crystal structure of a vaccine-elicited anti-HIV-1 rhesus macaque antibody DH846 | | 分子名称: | DH846 Fab heavy chain, DH846 Fab light chain | | 著者 | Chen, W.-H, Choe, M, Saunders, K.O, Joyce, M.G. | | 登録日 | 2019-08-30 | | 公開日 | 2021-03-24 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.806 Å) | | 主引用文献 | Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates.
Plos Pathog., 17, 2021
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6U6M
 | | Crystal structure of a vaccine-elicited anti-HIV-1 rhesus macaque antibody DH840.1 | | 分子名称: | DH840.1 Fab heavy chain, DH840.1 Fab light chain | | 著者 | Chen, W.-H, Choe, M, Saunders, K.O, Joyce, M.G. | | 登録日 | 2019-08-30 | | 公開日 | 2021-03-24 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.683 Å) | | 主引用文献 | Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates.
Plos Pathog., 17, 2021
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9BRY
 | | V0-only V-ATPase in synaptophysin gene knock-out mouse brain isolated synaptic vesicles | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Wang, C, Jiang, W, Yang, K, Wang, X, Guo, Q, Brunger, A.T. | | 登録日 | 2024-05-12 | | 公開日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structure and topography of the synaptic V-ATPase-synaptophysin complex.
Nature, 2024
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9BRR
 | | Intact V-ATPase State 3 in synaptophysin knock-out isolated synaptic vesicles | | 分子名称: | Renin receptor cytoplasmic fragment, Ribonuclease kappa, V-type proton ATPase 116 kDa subunit a 1, ... | | 著者 | Wang, C, Jiang, W, Yang, K, Wang, X, Guo, Q, Brunger, A.T. | | 登録日 | 2024-05-11 | | 公開日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Structure and topography of the synaptic V-ATPase-synaptophysin complex.
Nature, 2024
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9BRA
 | | Intact V-ATPase State 2 and synaptophysin complex in mouse brain isolated synaptic vesicles | | 分子名称: | Renin receptor cytoplasmic fragment, Ribonuclease kappa, Synaptophysin, ... | | 著者 | Wang, C, Jiang, W, Yang, K, Wang, X, Guo, Q, Brunger, A.T. | | 登録日 | 2024-05-11 | | 公開日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Structure and topography of the synaptic V-ATPase-synaptophysin complex.
Nature, 2024
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9BRQ
 | | Intact V-ATPase State 3 and synaptophysin complex in mouse brain isolated synaptic vesicles | | 分子名称: | Renin receptor cytoplasmic fragment, Ribonuclease kappa, Synaptophysin, ... | | 著者 | Wang, C, Jiang, W, Yang, K, Wang, X, Guo, Q, Brunger, A.T. | | 登録日 | 2024-05-11 | | 公開日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Structure and topography of the synaptic V-ATPase-synaptophysin complex.
Nature, 2024
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9BRU
 | | Intact V-ATPase State 1 in synaptophysin knock-out isolated synaptic vesicles | | 分子名称: | Renin receptor cytoplasmic fragment, Ribonuclease kappa, V-type proton ATPase 116 kDa subunit a 1, ... | | 著者 | Wang, C, Jiang, W, Yang, K, Wang, X, Guo, Q, Brunger, A.T. | | 登録日 | 2024-05-11 | | 公開日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Structure and topography of the synaptic V-ATPase-synaptophysin complex.
Nature, 2024
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9BRS
 | | Intact V-ATPase State 2 in synaptophysin knock-out isolated synaptic vesicles | | 分子名称: | Renin receptor cytoplasmic fragment, Ribonuclease kappa, V-type proton ATPase 116 kDa subunit a 1, ... | | 著者 | Wang, C, Jiang, W, Yang, K, Wang, X, Guo, Q, Brunger, A.T. | | 登録日 | 2024-05-11 | | 公開日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Structure and topography of the synaptic V-ATPase-synaptophysin complex.
Nature, 2024
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9BRT
 | | Intact V-ATPase State 1 and synaptophysin complex in mouse brain isolated synaptic vesicles | | 分子名称: | Renin receptor cytoplasmic fragment, Ribonuclease kappa, Synaptophysin, ... | | 著者 | Wang, C, Jiang, W, Yang, K, Wang, X, Guo, Q, Brunger, A.T. | | 登録日 | 2024-05-11 | | 公開日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Structure and topography of the synaptic V-ATPase-synaptophysin complex.
Nature, 2024
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9BRZ
 | | V0-only V-ATPase and synaptophysin complex in mouse brain isolated synaptic vesicles | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Wang, C, Jiang, W, Yang, K, Wang, X, Guo, Q, Brunger, A.T. | | 登録日 | 2024-05-12 | | 公開日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structure and topography of the synaptic V-ATPase-synaptophysin complex.
Nature, 2024
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6CRQ
 | | Glutaraldehyde-treated BG505 SOSIP.664 Env in complex with PGV04 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... | | 著者 | Pallesen, J, Ward, A.B. | | 登録日 | 2018-03-19 | | 公開日 | 2018-04-18 | | 最終更新日 | 2022-03-16 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins.
PLoS Pathog., 14, 2018
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3TPL
 | | APO Structure of BACE1 | | 分子名称: | Beta-secretase 1, CHLORIDE ION, SULFATE ION | | 著者 | Xu, Y.C, Li, M.J, Greenblatt, H, Chen, T.T, Silman, I, Sussman, J.L. | | 登録日 | 2011-09-08 | | 公開日 | 2011-11-23 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations
Acta Crystallogr.,Sect.D, 68, 2012
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3TPR
 | | Crystal structure of BACE1 complexed with an inhibitor | | 分子名称: | Beta-secretase 1, CHLORIDE ION, N-[(1S,2R)-1-BENZYL-3-(CYCLOPROPYLAMINO)-2-HYDROXYPROPYL]-5-[METHYL(METHYLSULFONYL)AMINO]-N'-[(1R)-1-PHENYLETHYL]ISOPHTHALAMIDE | | 著者 | Xu, Y.C, Li, M.J, Greenblatt, H, Chen, T.T, Silman, I, Sussman, J.L. | | 登録日 | 2011-09-08 | | 公開日 | 2011-11-23 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations
Acta Crystallogr.,Sect.D, 68, 2012
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3TPJ
 | | APO structure of BACE1 | | 分子名称: | Beta-secretase 1, CHLORIDE ION, SULFATE ION, ... | | 著者 | Xu, Y.C, Li, M.J, Greenblatt, H, Chen, T.T, Silman, I, Sussman, J.L. | | 登録日 | 2011-09-08 | | 公開日 | 2011-11-23 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | | 主引用文献 | Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations
Acta Crystallogr.,Sect.D, 68, 2012
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3TPP
 | | Crystal structure of BACE1 complexed with an inhibitor | | 分子名称: | Beta-secretase 1, CHLORIDE ION, N-[(1S,2R)-1-BENZYL-3-(CYCLOPROPYLAMINO)-2-HYDROXYPROPYL]-5-[METHYL(METHYLSULFONYL)AMINO]-N'-[(1R)-1-PHENYLETHYL]ISOPHTHALAMIDE, ... | | 著者 | Xu, Y.C, Li, M.J, Greenblatt, H, Chen, T.T, Silman, I, Sussman, J.L. | | 登録日 | 2011-09-08 | | 公開日 | 2011-11-23 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations
Acta Crystallogr.,Sect.D, 68, 2012
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3PNR
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6JM5
 | | Crystal structure of TBC1D23 C terminal domain | | 分子名称: | SODIUM ION, TBC1 domain family member 23 | | 著者 | Sun, Q, Huang, W. | | 登録日 | 2019-03-07 | | 公開日 | 2019-10-16 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural and functional studies of TBC1D23 C-terminal domain provide a link between endosomal trafficking and PCH.
Proc.Natl.Acad.Sci.USA, 116, 2019
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8HQ6
 | | KL2 in complex with CRM1-Ran-RanBP1 | | 分子名称: | CHLORIDE ION, CRM1 isoform 1, DIMETHYL SULFOXIDE, ... | | 著者 | Sun, Q, Jian, L. | | 登録日 | 2022-12-13 | | 公開日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors.
J.Med.Chem., 66, 2023
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8HQ3
 | | KL1 in complex with CRM1-Ran-RanBP1 | | 分子名称: | CHLORIDE ION, CRM1 isoform 1, DIMETHYL SULFOXIDE, ... | | 著者 | Sun, Q, Jian, L. | | 登録日 | 2022-12-13 | | 公開日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors.
J.Med.Chem., 66, 2023
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8HZD
 | | A new fluorescent RNA aptamer bound with N618 | | 分子名称: | 4-[(~{E})-2-[(4~{Z})-4-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]methylidene]-1-methyl-5-oxidanylidene-imidazol-2-yl]ethenyl]benzenecarbonitrile, MAGNESIUM ION, RNA (36-MER) | | 著者 | Song, Q.Q, Ren, A.M. | | 登録日 | 2023-01-09 | | 公開日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | | 主引用文献 | Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift.
Nat.Chem.Biol., 2024
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8HZJ
 | | A new fluorescent RNA aptamer bound with N571 | | 分子名称: | (5~{Z})-5-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]methylidene]-3-methyl-2-[(~{E})-2-phenylethenyl]imidazol-4-one, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Huang, K.Y, Ren, A.M. | | 登録日 | 2023-01-09 | | 公開日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift.
Nat.Chem.Biol., 2024
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