5KG9

Crystal structure of the gp120 v2 antibody RE505-22 Fab from IGH- and IGK-humanized mouse

Summary for 5KG9

Entry DOI	10.2210/pdb5kg9/pdb
Descriptor	Antibody RE505-22 Fab heavy chain, Antibody RE505-22 Fab light chain (3 entities in total)
Functional Keywords	hiv-1 gp120 antibody fab, immune system
Biological source	Mus musculus, Homo sapiens More
Total number of polymer chains	4
Total formula weight	94903.98
Authors	Nicely, N.I. (deposition date: 2016-06-13, release date: 2017-01-25, Last modification date: 2023-09-27)
Primary citation	Wiehe, K.,Nicely, N.I.,Lockwood, B.,Kuraoka, M.,Anasti, K.,Arora, S.,Bowman, C.M.,Stolarchuk, C.,Parks, R.,Lloyd, K.E.,Xia, S.M.,Duffy, R.,Shen, X.,Kyratsous, C.A.,Macdonald, L.E.,Murphy, A.J.,Scearce, R.M.,Moody, M.A.,Alam, S.M.,Verkoczy, L.,Tomaras, G.D.,Kelsoe, G.,Haynes, B.F. Immunodominance of Antibody Recognition of the HIV Envelope V2 Region in Ig-Humanized Mice. J. Immunol., 198:1047-1055, 2017 Cited by PubMed: 28011932 DOI: 10.4049/jimmunol.1601640 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation