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7AOG
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BU of 7aog by Molmil
14-3-3 sigma in complex with Pin1 binding site pS72
分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
著者Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C.
登録日2020-10-14
公開日2021-06-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
J.Am.Chem.Soc., 143, 2021
7AZ1
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BU of 7az1 by Molmil
14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1013
分子名称: 1-[4-methyl-3-(trifluoromethyl)phenyl]-2-phenyl-imidazole, 14-3-3 protein sigma, CALCIUM ION, ...
著者Wolter, M, Dijck, L.v, Ottmann, C.
登録日2020-11-14
公開日2021-06-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.
J.Am.Chem.Soc., 143, 2021
7B13
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BU of 7b13 by Molmil
14-3-3sigma in complex with SHN3pS542 phosphopeptide crystal structure
分子名称: 14-3-3 protein sigma, MAGNESIUM ION, SHN3pS542
著者Soini, L, Leysen, S, Davis, J, Ottmann, C.
登録日2020-11-23
公開日2021-09-29
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.37 Å)
主引用文献14-3-3 sigma in complex with phosphopeptides
To Be Published
7B15
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BU of 7b15 by Molmil
14-3-3sigma in complex with SHN3pT869 phosphopeptide crystal structure
分子名称: 14-3-3 protein sigma, MAGNESIUM ION, SHN3pT869
著者Soini, L, Leysen, S, Davis, J, Ottmann, C.
登録日2020-11-23
公開日2021-09-29
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献14-3-3 sigma in complex with phosphopeptides
To Be Published
5D3F
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BU of 5d3f by Molmil
Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768 and stabilizer fusicoccin-A
分子名称: 14-3-3 protein zeta/delta, Cystic fibrosis transmembrane conductance regulator, FUSICOCCIN
著者Stevers, L.M, Leysen, S.F.R, Ottmann, C.
登録日2015-08-06
公開日2016-03-16
最終更新日2019-03-13
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.
Proc.Natl.Acad.Sci.USA, 113, 2016
5D2D
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BU of 5d2d by Molmil
Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768
分子名称: 14-3-3 protein zeta/delta, CHLORIDE ION, Cystic fibrosis transmembrane conductance regulator, ...
著者Stevers, L.M, Leysen, S.F.R, Ottmann, C.
登録日2015-08-05
公開日2016-03-16
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.
Proc.Natl.Acad.Sci.USA, 113, 2016
5EC9
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BU of 5ec9 by Molmil
Retinoic acid receptor alpha in complex with chiral dihydrobenzofuran benzoic acid 9a and a fragment of the coactivator TIF2
分子名称: 4-[(11S,15R)-4,4,7,7-Tetramethyl-16-oxatetracyclo[8.6.0.03,8.011,15]hexadeca-1(10),2,8-trien-11-yl]benzoic acid, LYS-HIS-LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN-ASP, Retinoic acid receptor RXR-alpha
著者Leysen, S, Ottmann, C, Schafer, A, Scheepstra, M, Brunsveld, L, Sunden, R, Ma, J.N, Burnstein, E.S, Olsson, R.
登録日2015-10-20
公開日2016-03-09
最終更新日2022-08-10
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor-Nuclear Receptor Related 1 Protein Dimer Activation.
J.Med.Chem., 59, 2016
5D3E
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BU of 5d3e by Molmil
Crystal structure of human 14-3-3 gamma in complex with CFTR R-domain peptide pS768-pS795
分子名称: 14-3-3 protein gamma, Cystic fibrosis transmembrane conductance regulator
著者Stevers, L.M, Leysen, S.F.R, Ottmann, C.
登録日2015-08-06
公開日2016-03-16
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.
Proc.Natl.Acad.Sci.USA, 113, 2016
5EXA
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BU of 5exa by Molmil
Small-molecule stabilization of the 14-3-3/Gab2 PPI interface
分子名称: 14-3-3 protein zeta/delta, BENZOIC ACID, Fusicoccin A-THF derivative, ...
著者Bier, D, Ottmann, C.
登録日2015-11-23
公開日2016-05-04
最終更新日2018-12-19
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface.
Chemmedchem, 11, 2016
5EWZ
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BU of 5ewz by Molmil
Small-molecule stabilization of the 14-3-3/Gab2 PPI interface
分子名称: 14-3-3 protein zeta/delta, BENZOIC ACID, GRB2-associated-binding protein 2
著者Bier, D, Ottmann, C.
登録日2015-11-23
公開日2016-05-04
最終更新日2018-12-19
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface.
Chemmedchem, 11, 2016
5M37
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BU of 5m37 by Molmil
The molecular tweezer CLR01 stabilizes a disordered protein-protein interface
分子名称: (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene, 14-3-3 protein zeta/delta, BENZOIC ACID, ...
著者Bier, D, Ottmann, C.
登録日2016-10-14
公開日2017-11-15
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface.
J. Am. Chem. Soc., 139, 2017
4DX0
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BU of 4dx0 by Molmil
Structure of the 14-3-3/PMA2 complex stabilized by a pyrazole derivative
分子名称: 14-3-3-like protein E, 4-[(4R)-4-(4-nitrophenyl)-6-oxidanylidene-3-phenyl-1,4-dihydropyrrolo[3,4-c]pyrazol-5-yl]benzoic acid, N.plumbaginifolia H+-translocating ATPase mRNA
著者Richter, A, Rose, R, Hedberg, C, Waldmann, H, Ottmann, C.
登録日2012-02-27
公開日2012-05-30
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献An Optimised Small-Molecule Stabiliser of the 14-3-3-PMA2 Protein-Protein Interaction.
Chemistry, 18, 2012
5OEG
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BU of 5oeg by Molmil
Molecular tweezers modulate 14-3-3 protein-protein interactions
分子名称: (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene, 14-3-3 protein sigma, CHLORIDE ION
著者Bier, D, Ottmann, C.
登録日2017-07-07
公開日2017-07-26
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Molecular tweezers modulate 14-3-3 protein-protein interactions.
Nat Chem, 5, 2013
5M36
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BU of 5m36 by Molmil
The molecular tweezer CLR01 stabilizes a disordered protein-protein interface
分子名称: (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene, 14-3-3 protein zeta/delta, BENZOIC ACID, ...
著者Bier, D, Ottmann, C.
登録日2016-10-14
公開日2017-11-15
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface.
J. Am. Chem. Soc., 139, 2017
3T0L
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BU of 3t0l by Molmil
Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening
分子名称: 14-3-3 protein sigma, CHLORIDE ION, GLYCEROL, ...
著者Thiel, P, Ottmann, C.
登録日2011-07-20
公開日2012-12-26
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions.
Chem.Commun.(Camb.), 49, 2013
3T0M
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BU of 3t0m by Molmil
Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening
分子名称: (2-{2-[(2,5-dimethoxyphenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid, 14-3-3 protein sigma, CHLORIDE ION, ...
著者Thiel, P, Ottmann, C.
登録日2011-07-20
公開日2012-12-26
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions.
Chem.Commun.(Camb.), 49, 2013
5OEH
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BU of 5oeh by Molmil
Molecular tweezers modulate 14-3-3 protein-protein interactions.
分子名称: (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene, 14-3-3 protein sigma, CHLORIDE ION, ...
著者Bier, D, Ottmann, C.
登録日2017-07-07
公開日2017-07-26
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Molecular tweezers modulate 14-3-3 protein-protein interactions.
Nat Chem, 5, 2013
3UAL
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BU of 3ual by Molmil
Crystal Structure of 14-3-3 epsilon with Mlf1 peptide
分子名称: 14-3-3 protein epsilon, Myeloid leukemia factor 1, TERTIARY-BUTYL ALCOHOL
著者Weyand, M, Ottmann, C.
登録日2011-10-21
公開日2012-01-25
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural insights of the MLF1/14-3-3 interaction.
Febs J., 279, 2012
3U9X
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BU of 3u9x by Molmil
Covalent attachment of pyridoxal-phosphate derivatives to 14-3-3 proteins
分子名称: 14-3-3 protein sigma, CHLORIDE ION, GLYCEROL, ...
著者Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C.
登録日2011-10-20
公開日2012-05-09
最終更新日2012-05-16
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Covalent attachment of pyridoxal-phosphate derivatives to 14-3-3 proteins.
Proc.Natl.Acad.Sci.USA, 109, 2012
6FBB
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BU of 6fbb by Molmil
Crystal structure of 14-3-3 sigma in complex with wild-type Shroom3
分子名称: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ...
著者Leysen, S, Meijer, F.A, Milroy, L.G, Ottmann, C.
登録日2017-12-18
公開日2018-03-14
最終更新日2018-05-09
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Characterization of Coding/Noncoding Variants forSHROOM3in Patients with CKD.
J. Am. Soc. Nephrol., 29, 2018
6FCP
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BU of 6fcp by Molmil
Crystal structure of 14-3-3 sigma in complex with Shroom3 P1244L
分子名称: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ...
著者Leysen, S, Meijer, F.A, Milroy, L.G, Ottmann, C.
登録日2017-12-20
公開日2018-03-14
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Characterization of Coding/Noncoding Variants forSHROOM3in Patients with CKD.
J. Am. Soc. Nephrol., 29, 2018
6YO8
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BU of 6yo8 by Molmil
Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pT524 peptide
分子名称: 14-3-3 protein zeta/delta, Glucocorticoid receptor
著者Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C.
登録日2020-04-14
公開日2021-03-24
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators.
J.Biol.Chem., 296, 2021
6YMO
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BU of 6ymo by Molmil
Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pS617 peptide
分子名称: 14-3-3 protein zeta/delta, 2-HYDROXYBENZOIC ACID, Glucocorticoid receptor, ...
著者Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C.
登録日2020-04-09
公開日2021-03-24
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators.
J.Biol.Chem., 296, 2021
6YOS
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BU of 6yos by Molmil
Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pT524 pS617 peptide
分子名称: 14-3-3 protein zeta/delta, Glucocorticoid receptor,Glucocorticoid receptor
著者Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C.
登録日2020-04-15
公開日2021-03-24
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators.
J.Biol.Chem., 296, 2021
3LW1
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BU of 3lw1 by Molmil
Binary complex of 14-3-3 sigma and p53 pT387-peptide
分子名称: 14-3-3 protein sigma, CHLORIDE ION, GLYCEROL, ...
著者Schumacher, B, Mondry, J, Thiel, P, Weyand, M, Ottmann, C.
登録日2010-02-23
公開日2010-03-23
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.28 Å)
主引用文献Structure of the p53 C-terminus bound to 14-3-3: Implications for stabilization of the p53 tetramer
Febs Lett., 584, 2010

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