7SZQ
 
 | | Human P300 complexed with an azaindazole inhibitor | | 分子名称: | 1-[1-(4-chlorophenyl)cyclopentane-1-carbonyl]-N-1H-pyrazolo[4,3-b]pyridin-5-yl-D-prolinamide, Histone acetyltransferase p300 | | 著者 | Shewchuk, L.M, Reid, R.A. | | 登録日 | 2021-11-29 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening.
J.Med.Chem., 65, 2022
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7SSK
 | | Human P300 complexed with a glycine-based inhibitor | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Histone acetyltransferase p300, ... | | 著者 | Shewchuk, L.M, Reid, R.A. | | 登録日 | 2021-11-11 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | | 主引用文献 | Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening.
J.Med.Chem., 65, 2022
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7SS8
 | | Human P300 complexed with a proline-based inhibitor | | 分子名称: | 1,2-ETHANEDIOL, 1-[1-(4-chlorophenyl)cyclopentane-1-carbonyl]-N-{[3-(methylcarbamoyl)phenyl]methyl}-D-prolinamide, Histone acetyltransferase p300, ... | | 著者 | Shewchuk, L.M, Reid, R.A. | | 登録日 | 2021-11-10 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening.
J.Med.Chem., 65, 2022
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1A4A
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1A4C
 | | AZURIN MUTANT WITH MET 121 REPLACED BY HIS, PH 3.5 CRYSTAL FORM, DATA COLLECTED AT-180 DEGREES CELSIUS | | 分子名称: | AZURIN, COPPER (II) ION, NITRATE ION, ... | | 著者 | Messerschmidt, A, Prade, L. | | 登録日 | 1998-01-28 | | 公開日 | 1998-04-29 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Rack-induced metal binding vs. flexibility: Met121His azurin crystal structures at different pH.
Proc.Natl.Acad.Sci.USA, 95, 1998
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1B75
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1A4B
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8DT8
 | | LM18/Nb136 bispecific tetra-nanobody immunoglobulin in complex with SARS-CoV-2-6P-Mut7 S protein (focused refinement) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, LM18 nanobody, Nb136 nanobody, ... | | 著者 | Ozorowski, G, Turner, H.L, Ward, A.B. | | 登録日 | 2022-07-25 | | 公開日 | 2023-06-14 | | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | | 主引用文献 | Fully synthetic platform to rapidly generate tetravalent bispecific nanobody-based immunoglobulins.
Proc.Natl.Acad.Sci.USA, 120, 2023
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6U57
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8ELO
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8ELQ
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8ELP
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8GF2
 | | Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies eCR3022.20 and CC12.3 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CC12.3 Fab heavy chain, ... | | 著者 | Yuan, M, Zhu, X, Wilson, I.A. | | 登録日 | 2023-03-07 | | 公開日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.851 Å) | | 主引用文献 | Broadening a SARS-CoV-1-neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution.
Sci.Signal., 16, 2023
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8FEG
 | | CryoEM structure of Kappa Opioid Receptor bound to a semi-peptide and Gi1 | | 分子名称: | ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Fay, J.F, Che, T. | | 登録日 | 2022-12-06 | | 公開日 | 2023-12-06 | | 最終更新日 | 2024-01-17 | | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | | 主引用文献 | Design and structural validation of peptide-drug conjugate ligands of the kappa-opioid receptor.
Nat Commun, 14, 2023
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6FTR
 | | Serial Femtosecond Crystallography at Megahertz pulse rates | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | | 著者 | Wiedorn, M.O, Oberthuer, D, Barty, A, Chapman, H.N. | | 登録日 | 2018-02-23 | | 公開日 | 2018-10-10 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.76000106 Å) | | 主引用文献 | Megahertz serial crystallography.
Nat Commun, 9, 2018
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7AUW
 | | Inhibitory complex of human meprin beta with mouse fetuin-B. | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Fetuin-B, ... | | 著者 | Eckhard, U, Gomis-Ruth, F.X. | | 登録日 | 2020-11-03 | | 公開日 | 2021-04-14 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | The crystal structure of a 250-kDa heterotetrameric particle explains inhibition of sheddase meprin beta by endogenous fetuin-B.
Proc.Natl.Acad.Sci.USA, 118, 2021
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8Q7Y
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6GTH
 | | Serial Femtosecond Crystallography at Megahertz pulse rates | | 分子名称: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase | | 著者 | Wiedorn, M, Oberthuer, D, Werner, N, Schubert, R, White, T.A, Mancuso, A, Perbandt, M, Betzel, C, Barty, A, Chapman, H. | | 登録日 | 2018-06-18 | | 公開日 | 2018-10-10 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Megahertz serial crystallography.
Nat Commun, 9, 2018
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8BWT
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6TRP
 | | Solution Structure of Docking Domain Complex of Pax NRPS: PaxC NDD - PaxB CDD | | 分子名称: | Peptide synthetase XpsB,Peptide synthetase XpsB | | 著者 | Watzel, J, Hacker, C, Duchardt-Ferner, E, Bode, H.B, Woehnert, J. | | 登録日 | 2019-12-19 | | 公開日 | 2020-08-12 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A New Docking Domain Type in the Peptide-Antimicrobial-Xenorhabdus Peptide Producing Nonribosomal Peptide Synthetase fromXenorhabdus bovienii.
Acs Chem.Biol., 15, 2020
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7B2B
 | | Solution structure of a non-covalent extended docking domain complex of the Pax NRPS: PaxA T1-CDD/PaxB NDD | | 分子名称: | Amino acid adenylation domain-containing protein, Peptide synthetase PaxA | | 著者 | Watzel, J, Sarawi, S, Duchardt-Ferner, E, Bode, H.B, Woehnert, J. | | 登録日 | 2020-11-26 | | 公開日 | 2021-06-16 | | 最終更新日 | 2024-07-03 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Cooperation between a T Domain and a Minimal C-Terminal Docking Domain to Enable Specific Assembly in a Multiprotein NRPS.
Angew.Chem.Int.Ed.Engl., 60, 2021
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7B2F
 | | Solution structure of the Pax NRPS docking domain PaxB NDD | | 分子名称: | Peptide synthetase XpsB (Modular protein) | | 著者 | Watzel, J, Sarawi, S, Duchardt-Ferner, E, Bode, H.B, Woehnert, J. | | 登録日 | 2020-11-26 | | 公開日 | 2021-06-09 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Cooperation between a T Domain and a Minimal C-Terminal Docking Domain to Enable Specific Assembly in a Multiprotein NRPS.
Angew.Chem.Int.Ed.Engl., 60, 2021
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7ZOC
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3RKF
 | | Crystal structure of guanine riboswitch C61U/G37A double mutant bound to thio-guanine | | 分子名称: | 2-amino-1,9-dihydro-6H-purine-6-thione, COBALT HEXAMMINE(III), Guanine riboswitch | | 著者 | Buck, J, Wacker, A, Warkentin, E, Woehnert, J, Wirmer-Bartoschek, J, Schwalbe, H. | | 登録日 | 2011-04-18 | | 公開日 | 2011-08-17 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Influence of ground-state structure and Mg2+ binding on folding kinetics of the guanine-sensing riboswitch aptamer domain.
Nucleic Acids Res., 39, 2011
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1ABW
 | | DEOXY RHB1.1 (RECOMBINANT HEMOGLOBIN) | | 分子名称: | HEMOGLOBIN-BASED BLOOD SUBSTITUTE, LEUCINE, METHIONINE, ... | | 著者 | Kundrot, C.E, Kroeger, K.S. | | 登録日 | 1997-01-29 | | 公開日 | 1998-06-17 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structures of a hemoglobin-based blood substitute: insights into the function of allosteric proteins.
Structure, 5, 1997
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