7PCG
 
 | | BurG (holo) in complex with cyclopropane-1,1-dicarboxylate (7): Biosynthesis of cyclopropanol rings in bacterial toxins | | 分子名称: | GLYCEROL, Ketol-acid reductoisomerase, MAGNESIUM ION, ... | | 著者 | Trottmann, F, Ishida, K, Ishida, M, Kries, H, Groll, M, Hertweck, C. | | 登録日 | 2021-08-03 | | 公開日 | 2022-08-10 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead.
Nat.Chem., 14, 2022
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2DVJ
 | | phosphorylated Crk-II | | 分子名称: | V-crk sarcoma virus CT10 oncogene homolog, isoform a | | 著者 | Kobashigawa, Y, Inagaki, F. | | 登録日 | 2006-07-31 | | 公開日 | 2007-05-08 | | 最終更新日 | 2022-03-09 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK.
Nat.Struct.Mol.Biol., 14, 2007
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8IJU
 | | ATP-dependent RNA helicase DDX39A (URH49delta41) | | 分子名称: | 1,2-ETHANEDIOL, ATP-dependent RNA helicase DDX39A, PHOSPHATE ION, ... | | 著者 | Mikami, B, Fujita, K, Masuda, S, Kojima, M. | | 登録日 | 2023-02-28 | | 公開日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Structural differences between the closely related RNA helicases, UAP56 and URH49, fashion distinct functional apo-complexes.
Nat Commun, 15, 2024
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6AAJ
 | | Crystal structure of JAK2 in complex with peficitinib | | 分子名称: | 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide, Tyrosine-protein kinase JAK2 | | 著者 | Amano, Y, Tateishi, Y. | | 登録日 | 2018-07-18 | | 公開日 | 2018-08-15 | | 最終更新日 | 2023-03-08 | | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | | 主引用文献 | Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor
Bioorg. Med. Chem., 26, 2018
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6AAM
 | | Crystal structure of TYK2 in complex with peficitinib | | 分子名称: | 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide, Non-receptor tyrosine-protein kinase TYK2 | | 著者 | Nomura, N, Tomimoto, Y. | | 登録日 | 2018-07-18 | | 公開日 | 2018-08-15 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor
Bioorg. Med. Chem., 26, 2018
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6AAH
 | | Crystal structure of JAK1 in complex with peficitinib | | 分子名称: | 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide, Tyrosine-protein kinase JAK1 | | 著者 | Amano, Y. | | 登録日 | 2018-07-18 | | 公開日 | 2018-08-15 | | 最終更新日 | 2018-10-24 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor
Bioorg. Med. Chem., 26, 2018
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6AAK
 | | Crystal structure of JAK3 in complex with peficitinib | | 分子名称: | 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide, Tyrosine-protein kinase JAK3 | | 著者 | Amano, Y. | | 登録日 | 2018-07-18 | | 公開日 | 2018-08-15 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | | 主引用文献 | Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor
Bioorg. Med. Chem., 26, 2018
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2D7H
 | | Crystal structure of the ccc complex of the N-terminal domain of PriA | | 分子名称: | DNA (5'-D(P*CP*CP*C)-3'), Primosomal protein N' | | 著者 | Sasaki, K, Ose, T, Maenaka, K, Masai, H, Kohda, D. | | 登録日 | 2005-11-21 | | 公開日 | 2006-11-07 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural basis of the 3'-end recognition of a leading strand in stalled replication forks by PriA.
EMBO J., 26, 2007
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2D7E
 | | Crystal structure of N-terminal domain of PriA from E.coli | | 分子名称: | Primosomal protein N' | | 著者 | Sasaki, K, Ose, T, Maenaka, K, Masai, H, Kohda, D. | | 登録日 | 2005-11-18 | | 公開日 | 2006-11-07 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural basis of the 3'-end recognition of a leading strand in stalled replication forks by PriA.
EMBO J., 26, 2007
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2D7G
 | | Crystal structure of the aa complex of the N-terminal domain of PriA | | 分子名称: | DNA (5'-D(P*AP*A)-3'), Primosomal protein N' | | 著者 | Sasaki, K, Ose, T, Maenaka, K, Masai, H, Kohda, D. | | 登録日 | 2005-11-21 | | 公開日 | 2006-11-07 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structural basis of the 3'-end recognition of a leading strand in stalled replication forks by PriA.
EMBO J., 26, 2007
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2DWN
 | | Crystal structure of the PriA protein complexed with oligonucleotides | | 分子名称: | DNA (5'-D(*A*G)-3'), Primosomal protein N' | | 著者 | Sasaki, K, Ose, T, Tanaka, T, Masai, H, Maenaka, K, Kohda, D. | | 登録日 | 2006-08-15 | | 公開日 | 2006-11-07 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | | 主引用文献 | Structural basis of the 3'-end recognition of a leading strand in stalled replication forks by PriA.
EMBO J., 26, 2007
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5B4F
 | | Sulfur Transferase TtuA in complex with iron sulfur cluster | | 分子名称: | IRON/SULFUR CLUSTER, SULFATE ION, Sulfur Transferase TtuA, ... | | 著者 | Chen, M, Narai, S, Tanaka, Y, Yao, M. | | 登録日 | 2016-04-03 | | 公開日 | 2017-05-10 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Biochemical and structural characterization of oxygen-sensitive 2-thiouridine synthesis catalyzed by an iron-sulfur protein TtuA
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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3L56
 | | Crystal structure of the large c-terminal domain of polymerase basic protein 2 from influenza virus a/viet nam/1203/2004 (h5n1) | | 分子名称: | Polymerase PB2 | | 著者 | Staker, B.L, Edwards, T, Eric, S, Raymond, A, Stewart, L, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | | 登録日 | 2009-12-21 | | 公開日 | 2010-03-09 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Biological and structural characterization of a host-adapting amino acid in influenza virus.
Plos Pathog., 6, 2010
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2DWL
 | | Crystal structure of the PriA protein complexed with oligonucleotides | | 分子名称: | 5'-D(*AP*(DC))-3', Primosomal protein N | | 著者 | Sasaki, K, Ose, T, Tanaka, T, Masai, H, Maenaka, K, Kohda, D. | | 登録日 | 2006-08-15 | | 公開日 | 2006-11-07 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural basis of the 3'-end recognition of a leading strand in stalled replication forks by PriA.
EMBO J., 26, 2007
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2DWM
 | | Crystal structure of the PriA protein complexed with oligonucleotides | | 分子名称: | 5'-D(*AP*T)-3', Primosomal protein N | | 著者 | Sasaki, K, Ose, T, Tanaka, T, Masai, H, Maenaka, K, Kohda, D. | | 登録日 | 2006-08-15 | | 公開日 | 2006-11-07 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Structural basis of the 3'-end recognition of a leading strand in stalled replication forks by PriA.
EMBO J., 26, 2007
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3KC6
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3KHW
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1LOP
 | | CYCLOPHILIN A COMPLEXED WITH SUCCINYL-ALA-PRO-ALA-P-NITROANILIDE | | 分子名称: | CYCLOPHILIN A, SUCCINYL-ALA-PRO-ALA-P-NITROANILIDE | | 著者 | Konno, M. | | 登録日 | 1996-06-17 | | 公開日 | 1996-12-23 | | 最終更新日 | 2017-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The substrate-binding site in Escherichia coli cyclophilin A preferably recognizes a cis-proline isomer or a highly distorted form of the trans isomer.
J.Mol.Biol., 256, 1996
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7E0G
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6E3H
 | | Crystal structure of S9-3-37 bound to H5 influenza hemagglutinin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1, ... | | 著者 | Wu, N.C, Wilson, I.A. | | 登録日 | 2018-07-14 | | 公開日 | 2018-09-26 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | The D3-9 gene segment encodes for recurring and adaptable binding motifs in broadly neutralizing antibodies to influenza virus
Cell Host Microbe, 2018
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4YN8
 | | Crystal Structure of Response Regulator ChrA in Heme-Sensing Two Component System | | 分子名称: | MAGNESIUM ION, Response regulator ChrA, SULFATE ION | | 著者 | Doi, A, Nakamura, H, Shiro, Y, Sugimoto, H. | | 登録日 | 2015-03-09 | | 公開日 | 2015-08-19 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure of the response regulator ChrA in the haem-sensing two-component system of Corynebacterium diphtheriae.
Acta Crystallogr.,Sect.F, 71, 2015
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3VPL
 | | Crystal structure of a 2-fluoroxylotriosyl complex of the Vibrio sp. AX-4 Beta-1,3-xylanase | | 分子名称: | 3,4-dinitrophenol, Beta-1,3-xylanase XYL4, beta-D-xylopyranose-(1-3)-beta-D-xylopyranose-(1-3)-2-deoxy-2-fluoro-beta-D-xylopyranose, ... | | 著者 | Watanabe, N, Sakaguchi, K. | | 登録日 | 2012-03-05 | | 公開日 | 2013-03-06 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | The crystal structure of a 2-fluoroxylotriosyl complex of the Vibrio sp. AX-4 beta-1,3-xylanase at 1.2 A resolution
To be Published
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2IBX
 | | Influenza virus (VN1194) H5 HA | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin | | 著者 | Yamada, S, Russell, R.J, Gamblin, S.J, Skehel, J.J, Kawaoka, Y. | | 登録日 | 2006-09-12 | | 公開日 | 2006-11-28 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors.
Nature, 444, 2006
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1TLK
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4X5X
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