7E0G

Crystal structure of Lysine Specific Demethylase 1 (LSD1) with TAK-418, FAD-adduct

Summary for 7E0G

• Entry DOI: 10.2210/pdb7e0g/pdb
• Descriptor: Lysine-specific histone demethylase 1A, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4S)-5-[5-methanoyl-7,8-dimethyl-2,4-bis(oxidanylidene)-1H-benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate, GLYCEROL, ... (6 entities in total)
• Functional Keywords: inhibitor, tak-418, fad-adduct, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 74947.87

Authors

Oki, H. (deposition date: 2021-01-28, release date: 2021-03-24, Last modification date: 2023-11-29)

• Primary citation: Baba, R.,Matsuda, S.,Arakawa, Y.,Yamada, R.,Suzuki, N.,Ando, T.,Oki, H.,Igaki, S.,Daini, M.,Hattori, Y.,Matsumoto, S.,Ito, M.,Nakatani, A.,Kimura, H.; LSD1 enzyme inhibitor TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models.; Sci Adv, 7:-, 2021; PubMed: 33712455; DOI: 10.1126/sciadv.aba1187

Experimental method

X-RAY DIFFRACTION (2.25 Å)