7E0G
Crystal structure of Lysine Specific Demethylase 1 (LSD1) with TAK-418, FAD-adduct
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lysine-specific histone demethylase 1A | polymer | 665 | 73853.4 | 1 | UniProt (O60341) Pfam (PF04433) Pfam (PF01593) | Homo sapiens (Human) | BRAF35-HDAC complex protein BHC110,Flavin-containing amine oxidase domain-containing protein 2,[histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A |
| 2 | B (A) | [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4S)-5-[5-methanoyl-7,8-dimethyl-2,4-bis(oxidanylidene)-1H-benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate | non-polymer | 815.6 | 1 | Chemie (HUF) | |||
| 3 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | D, E (A) | IMIDAZOLE | non-polymer | 69.1 | 2 | Chemie (IMD) | |||
| 5 | F, G (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | H (A) | water | water | 18.0 | 208 | Chemie (HOH) |
Sequence modifications
A: 172 - 833 (UniProt: O60341)
| PDB | External Database | Details |
|---|---|---|
| Gly 169 | - | expression tag |
| Gly 170 | - | expression tag |
| Ser 171 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 73853.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1094.5 | |
| All* | Total formula weight | 74947.9 |
