7AK0
 
 | | Human MALT1(329-729) in complex with a chromane urea containing inhibitor | | 分子名称: | 1-[4-[4-(aminomethyl)pyrazol-1-yl]-3-chloranyl-phenyl]-3-[(3~{R})-6-bromanyl-3,4-dihydro-2~{H}-chromen-3-yl]urea, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | | 著者 | Renatus, M. | | 登録日 | 2020-09-29 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.316 Å) | | 主引用文献 | Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing.
J.Med.Chem., 63, 2020
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7AK1
 | | Human MALT1(329-729) in complex with a chromane urea containing inhibitor | | 分子名称: | 1-(3-chloranyl-4-methoxy-phenyl)-3-[7-[(3~{S})-3-(methoxymethyl)morpholin-4-yl]-2-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]urea, MAGNESIUM ION, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | | 著者 | Renatus, M. | | 登録日 | 2020-09-29 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.507 Å) | | 主引用文献 | Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing.
J.Med.Chem., 63, 2020
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6SAK
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8FEF
 | | Structure of Mce1 transporter from Mycobacterium smegmatis (Map0) | | 分子名称: | ABC transporter, ATP-binding protein,Green fluorescent protein chimera, ABC-transporter integral membrane protein, ... | | 著者 | Chen, J, Bhabha, G, Ekiert, D.C. | | 登録日 | 2022-12-06 | | 公開日 | 2023-02-22 | | 最終更新日 | 2023-08-23 | | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | | 主引用文献 | Structure of an endogenous mycobacterial MCE lipid transporter.
Nature, 620, 2023
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8FED
 | | Structure of Mce1-LucB complex from Mycobacterium smegmatis (Map1) | | 分子名称: | ABC transporter, ATP-binding protein,Green fluorescent protein chimera, ABC-transporter integral membrane protein, ... | | 著者 | Chen, J, Bhabha, G, Ekiert, D.C. | | 登録日 | 2022-12-06 | | 公開日 | 2023-02-22 | | 最終更新日 | 2023-08-23 | | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | | 主引用文献 | Structure of an endogenous mycobacterial MCE lipid transporter.
Nature, 620, 2023
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8FEE
 | | Structure of Mce1 transporter from Mycobacterium smegmatis in the absence of LucB (Map2) | | 分子名称: | ABC transporter, ATP-binding protein,Green fluorescent protein chimera, ABC-transporter integral membrane protein, ... | | 著者 | Chen, J, Bhabha, G, Ekiert, D.C. | | 登録日 | 2022-12-06 | | 公開日 | 2023-02-22 | | 最終更新日 | 2023-08-23 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structure of an endogenous mycobacterial MCE lipid transporter.
Nature, 620, 2023
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3Q2V
 | | Crystal structure of mouse E-cadherin ectodomain | | 分子名称: | CALCIUM ION, Cadherin-1, MANGANESE (II) ION, ... | | 著者 | Jin, X, Harrison, O.J, Shapiro, L. | | 登録日 | 2010-12-20 | | 公開日 | 2011-04-06 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins.
Structure, 19, 2011
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3Q2W
 | | Crystal structure of mouse N-cadherin ectodomain | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Jin, X, Shapiro, L. | | 登録日 | 2010-12-20 | | 公開日 | 2011-02-23 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins.
Structure, 19, 2011
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3Q2L
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3Q2N
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1W3Y
 | | Crystal structure of S. pneumoniae hyaluronate lyase in complex with palmitoyl-vitamin C | | 分子名称: | (2E,4R,5S)-2,3,4,5-TETRAHYDROXY-6-(PALMITOYLOXY)HEX-2-ENOIC ACID, HYALURONATE LYASE, SULFATE ION, ... | | 著者 | Rigden, D.J, Jedrzejas, M.J. | | 登録日 | 2004-07-21 | | 公開日 | 2004-08-26 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | L-Ascorbic Acid 6-Hexadecanoate, a Potent Hyaluronidase Inhibitor: X-Ray Structure and Molecular Modeling of Enzyme-Inhibitor Complexes
J.Biol.Chem., 279, 2004
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3OOZ
 | | Bace1 in complex with the aminohydantoin Compound 102 | | 分子名称: | (5R)-2-amino-5-[4-(difluoromethoxy)phenyl]-5-[4-fluoro-3-(5-fluoropent-1-yn-1-yl)phenyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one, Beta-secretase 1 | | 著者 | Olland, A.M. | | 登録日 | 2010-08-31 | | 公開日 | 2011-08-31 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Design and Synthesis of Aminohydantoins as Potent and Selective Human beta-Secretase (BACE1) Inhibitors with Enhanced Brain Permeability
Bioorg.Med.Chem.Lett., 20, 2010
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8BEC
 | | Crystal structure of the SARS-CoV-2 S RBD in complex with pT1375 scFV | | 分子名称: | SULFATE ION, Spike protein S1, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Hansen, G, Ssebyatika, G.L, Krey, T. | | 登録日 | 2022-10-21 | | 公開日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Activity of broadly neutralizing antibodies against sarbecoviruses: a trade-off between SARS-CoV-2 variants and distant coronaviruses?
To be published
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8BG1
 | | Crystal structure of the SARS-CoV-2 S RBD in complex with pT1511 scFV | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Hansen, G, Ssebyatika, G.L, Krey, T. | | 登録日 | 2022-10-27 | | 公開日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.88 Å) | | 主引用文献 | Activity of broadly neutralizing antibodies against sarbecoviruses: a trade-off between SARS-CoV-2 variants and distant coronaviruses?
To be published
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8BG2
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8BG3
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8BG5
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8BG4
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8BG6
 | | SARS-CoV-2 S protein in complex with pT1644 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, pT1644 Fab heavy chain, ... | | 著者 | Stroeh, L, Hansen, G, Vollmer, B, Krey, T, Benecke, T, Gruenewald, K. | | 登録日 | 2022-10-27 | | 公開日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (4.11 Å) | | 主引用文献 | Activity of broadly neutralizing antibodies against sarbecoviruses: a trade-off between SARS-CoV-2 variants and distant coronaviruses?
To be published
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8BG8
 | | SARS-CoV-2 S protein in complex with pT1696 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, pT1696 Fab heavy chain, ... | | 著者 | Hansen, G, Benecke, T, Vollmer, B, Gruenewald, K, Krey, T. | | 登録日 | 2022-10-27 | | 公開日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | | 主引用文献 | Activity of broadly neutralizing antibodies against sarbecoviruses: a trade-off between SARS-CoV-2 variants and distant coronaviruses?
To be published
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7A0N
 | | Structure of TSC1 NTD and linker domain | | 分子名称: | Uncharacterized protein,Uncharacterized protein | | 著者 | Fitzian, K, Kuemmel, D. | | 登録日 | 2020-08-10 | | 公開日 | 2021-05-26 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (4.3 Å) | | 主引用文献 | TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation.
Mol.Cell, 81, 2021
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7A0M
 | | TSC1 N-terminal domain | | 分子名称: | SULFATE ION, TSC1 N-terminal domain | | 著者 | Zech, R, Kiontke, S, Kuemmel, D. | | 登録日 | 2020-08-10 | | 公開日 | 2021-05-26 | | 最終更新日 | 2021-07-14 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation.
Mol.Cell, 81, 2021
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6SSH
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2MMM
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3S7L
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