6MOL
| Monoextended DARPin M_R12 complex with EpoR | 分子名称: | Erythropoietin receptor, GLYCEROL, Monoextended DARPin R12 (M_R12) | 著者 | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | 登録日 | 2018-10-04 | 公開日 | 2019-06-05 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (3.163 Å) | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
|
|
6MOF
| Monomeric DARPin G2 complex with EpoR | 分子名称: | 1,2-ETHANEDIOL, Erythropoietin receptor, G2 DARPin | 著者 | Jude, K.M, Mohan, K, Garcia, K.C. | 登録日 | 2018-10-04 | 公開日 | 2019-06-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.894 Å) | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
|
|
6NE2
| Designed repeat protein in complex with Fz7 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | 著者 | Miao, Y, Jude, K.M, Garcia, K.C. | 登録日 | 2018-12-15 | 公開日 | 2019-05-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.299 Å) | 主引用文献 | Receptor subtype discrimination using extensive shape complementary designed interfaces. Nat.Struct.Mol.Biol., 26, 2019
|
|
6NE1
| Designed repeat protein in complex with Fz4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-4, Pfs, ... | 著者 | Miao, Y, Jude, K.M, Garcia, K.C. | 登録日 | 2018-12-15 | 公開日 | 2019-05-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.011 Å) | 主引用文献 | Receptor subtype discrimination using extensive shape complementary designed interfaces. Nat.Struct.Mol.Biol., 26, 2019
|
|
6NE4
| Designed repeat protein specifically in complex with Fz7CRD | 分子名称: | 1,2-ETHANEDIOL, Designed repeat binding protein, Frizzled-7, ... | 著者 | Miao, Y, Jude, K.M, Garcia, K.C. | 登録日 | 2018-12-16 | 公開日 | 2019-05-15 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.648 Å) | 主引用文献 | Receptor subtype discrimination using extensive shape complementary designed interfaces. Nat.Struct.Mol.Biol., 26, 2019
|
|
6NDZ
| Designed repeat protein in complex with Fz8 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ACETIC ACID, ... | 著者 | Miao, Y, Jude, K.M, Garcia, K.C. | 登録日 | 2018-12-14 | 公開日 | 2019-05-15 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (2.264 Å) | 主引用文献 | Receptor subtype discrimination using extensive shape complementary designed interfaces. Nat.Struct.Mol.Biol., 26, 2019
|
|
2GYZ
| Crystal structure of human artemin | 分子名称: | neurotrophic factor artemin isoform 3 | 著者 | Wang, X.Q, Garcia, K.C. | 登録日 | 2006-05-10 | 公開日 | 2006-06-27 | 最終更新日 | 2024-10-30 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Structure of Artemin Complexed with Its Receptor GFRalpha3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors. Structure, 14, 2006
|
|
2H3N
| |
2IFG
| |
7RA9
| Designed StabIL-2 seq1 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Interleukin-2, PHOSPHATE ION | 著者 | Jude, K.M, Chu, A.E, Huang, P.-S, Garcia, K.C. | 登録日 | 2021-06-30 | 公開日 | 2022-03-16 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Interleukin-2 superkines by computational design. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
3TJH
| 42F3-p3A1/H2-Ld complex | 分子名称: | 42F3 alpha, 42F3 beta, H2-Ld SBM2, ... | 著者 | Adams, J.J, Kruse, A, Kranz, D.M, Garcia, K.C. | 登録日 | 2011-08-24 | 公開日 | 2011-12-07 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex. Immunity, 35, 2011
|
|
3S8W
| D2 domain of human IFNAR2 | 分子名称: | CHLORIDE ION, Interferon alpha/beta receptor 2 | 著者 | Thomas, C, Garcia, K.C. | 登録日 | 2011-05-31 | 公開日 | 2011-08-31 | 最終更新日 | 2012-03-21 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell(Cambridge,Mass.), 146, 2011
|
|
3E3Q
| |
7S2R
| nanobody bound to IL-2Rg | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, ... | 著者 | Glassman, C.R, Jude, K.M, Yen, M, Garcia, K.C. | 登録日 | 2021-09-03 | 公開日 | 2022-03-30 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Facile discovery of surrogate cytokine agonists. Cell, 185, 2022
|
|
7S2S
| nanobody bound to Interleukin-2Rbeta | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, IL2Rb-binding nanobody, Interleukin-2 receptor subunit beta, ... | 著者 | Glassman, C.R, Jude, K.M, Yen, M, Garcia, K.C. | 登録日 | 2021-09-03 | 公開日 | 2022-03-30 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Facile discovery of surrogate cytokine agonists. Cell, 185, 2022
|
|
2RKC
| |
3EEB
| Structure of the V. cholerae RTX cysteine protease domain | 分子名称: | INOSITOL HEXAKISPHOSPHATE, RTX toxin RtxA, SODIUM ION | 著者 | Lupardus, P.J, Shen, A, Bogyo, M, Garcia, K.C. | 登録日 | 2008-09-04 | 公開日 | 2008-10-21 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain Science, 322, 2008
|
|
3TFK
| 42F3-p4B10/H2-Ld | 分子名称: | 42F3 alpha, 42F3 beta, H2-Ld SBM2, ... | 著者 | Adams, J.J, Kranz, D.M, Garcia, K.C. | 登録日 | 2011-08-15 | 公開日 | 2011-12-07 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.753 Å) | 主引用文献 | T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex. Immunity, 35, 2011
|
|
3DUH
| Structure of Interleukin-23 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 subunit beta, Interleukin-23 subunit alpha | 著者 | Lupardus, P.J, Garcia, K.C. | 登録日 | 2008-07-17 | 公開日 | 2008-08-19 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12. J.Mol.Biol., 382, 2008
|
|
3E2H
| |
3E0G
| Structure of the Leukemia Inhibitory Factor Receptor (LIF-R) domains D1-D5 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Leukemia inhibitory factor receptor, ... | 著者 | Lupardus, P.J, Garcia, K.C. | 登録日 | 2008-07-31 | 公開日 | 2008-09-23 | 最終更新日 | 2024-10-30 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex. Mol.Cell, 31, 2008
|
|
3TF7
| 42F3 QL9/H2-Ld complex | 分子名称: | 42F3 Mut7 scFv (42F3 alpha chain, linker, 42F3 beta chain), ... | 著者 | Adams, J.J, Kranz, D.M, Garcia, K.C. | 登録日 | 2011-08-15 | 公開日 | 2011-12-07 | 最終更新日 | 2024-10-30 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex. Immunity, 35, 2011
|
|
3TPU
| 42F3 p5E8/H2-Ld complex | 分子名称: | 1,2-ETHANEDIOL, 42F3 alpha, 42F3 beta, ... | 著者 | Adams, J.J, Kranz, D.M, Garcia, K.C. | 登録日 | 2011-09-08 | 公開日 | 2011-12-07 | 最終更新日 | 2024-10-30 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex. Immunity, 35, 2011
|
|
5E4E
| Engineered Interleukin-13 bound to receptor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-13, Interleukin-13 receptor subunit alpha-1, ... | 著者 | Moraga, I, Thomas, C, Jude, K.M, Garcia, K.C. | 登録日 | 2015-10-05 | 公開日 | 2015-12-02 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency. Sci.Signal., 8, 2015
|
|
5EO9
| Crystal Structure of the complex of Dpr6 Domain 1 bound to DIP-alpha Domain 1+2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CG32791, isoform A, ... | 著者 | Ozkan, E, Zinn, K, Garcia, K.C. | 登録日 | 2015-11-10 | 公開日 | 2016-01-06 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.2988 Å) | 主引用文献 | Control of Synaptic Connectivity by a Network of Drosophila IgSF Cell Surface Proteins. Cell, 163, 2015
|
|