3PO2
 
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3QWD
 | | Crystal structure of ClpP from Staphylococcus aureus | | 分子名称: | ATP-dependent Clp protease proteolytic subunit, CHLORIDE ION | | 著者 | Geiger, S.R, Boettcher, T, Sieber, S.A, Cramer, P. | | 登録日 | 2011-02-28 | | 公開日 | 2011-05-18 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | A Conformational Switch Underlies ClpP Protease Function.
Angew.Chem.Int.Ed.Engl., 50, 2011
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3R84
 | | Structure of the Mediator head subcomplex Med11/22 | | 分子名称: | Mediator of RNA polymerase II transcription subunit 11, Mediator of RNA polymerase II transcription subunit 22 | | 著者 | Seizl, M, Lariviere, L, Pfaffenender, T, Wenzeck, L, Cramer, P. | | 登録日 | 2011-03-23 | | 公開日 | 2011-04-27 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization.
Nucleic Acids Res., 39, 2011
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1Y77
 | | Complete RNA Polymerase II elongation complex with substrate analogue GMPCPP | | 分子名称: | 5'-D(*AP*AP*GP*TP*AP*CP*T)-3', 5'-D(P*AP*GP*TP*AP*CP*TP*TP*AP*CP*T*CP*GP*CP*CP*TP*GP*GP*TP*CP*TP*G)-3', 5'-R(*AP*AP*GP*AP*CP*CP*AP*GP*GP*C)-3', ... | | 著者 | Kettenberger, H, Armache, K.-J, Cramer, P. | | 登録日 | 2004-12-08 | | 公開日 | 2005-01-04 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (4.5 Å) | | 主引用文献 | Complete RNA Polymerase II Elongation Complex Structure and Its Interactions with NTP and TFIIS
Mol.Cell, 16, 2004
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2HZS
 | | Structure of the Mediator head submodule Med8C/18/20 | | 分子名称: | RNA polymerase II mediator complex subunit 18, RNA polymerase II mediator complex subunit 20, RNA polymerase II mediator complex subunit 8 | | 著者 | Lariviere, L, Geiger, S, Hoeppner, S, Rother, S, Straesser, K, Cramer, P. | | 登録日 | 2006-08-09 | | 公開日 | 2006-09-12 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structure and TBP binding of the Mediator head subcomplex Med8-Med18-Med20.
Nat.Struct.Mol.Biol., 13, 2006
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7A9W
 | | Structure of yeast Rmd9p in complex with 20nt target RNA | | 分子名称: | CHLORIDE ION, Protein RMD9, mitochondrial, ... | | 著者 | Hillen, H.S, Markov, D.A, Ireneusz, W.D, Hofmann, K.B, Cowan, A.T, Jones, J.L, Temiakov, D, Cramer, P, Anikin, M. | | 登録日 | 2020-09-02 | | 公開日 | 2021-04-07 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | The pentatricopeptide repeat protein Rmd9 recognizes the dodecameric element in the 3'-UTRs of yeast mitochondrial mRNAs.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7A9X
 | | Structure of yeast Rmd9p in complex with 16nt target RNA | | 分子名称: | CHLORIDE ION, Protein RMD9, mitochondrial, ... | | 著者 | Hillen, H.S, Markov, D.A, Ireneusz, W.D, Hofmann, K.B, Cowan, A.T, Jones, J.L, Temiakov, D, Cramer, P, Anikin, M. | | 登録日 | 2020-09-02 | | 公開日 | 2021-04-07 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | The pentatricopeptide repeat protein Rmd9 recognizes the dodecameric element in the 3'-UTRs of yeast mitochondrial mRNAs.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7B3D
 | | Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with AMP at position -4 (structure 3) | | 分子名称: | RNA (5'-R(P*CP*UP*AP*CP*GP*CP*AP*GP*UP*G)-3'), RNA (5'-R(P*UP*GP*CP*AP*CP*UP*GP*CP*GP*UP*AP*G)-3'), SARS-CoV-2 RNA-dependent RNA polymerase nsp12, ... | | 著者 | Kokic, G, Hillen, H.S, Tegunov, D, Dienemann, C, Seitz, F, Schmitzova, J, Farnung, L, Siewert, A, Hoebartner, C, Cramer, P. | | 登録日 | 2020-11-30 | | 公開日 | 2020-12-23 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Mechanism of SARS-CoV-2 polymerase stalling by remdesivir.
Nat Commun, 12, 2021
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7B3B
 | | Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with Remdesivir at position -3 (structure 1) | | 分子名称: | DNA/RNA (5'-R(P*CP*UP*AP*CP*GP*CP*G)-D(P*(RMP))-R(P*UP*G)-3'), Non-structural protein 7, Non-structural protein 8, ... | | 著者 | Kokic, G, Hillen, H.S, Tegunov, D, Dienemann, C, Seitz, F, Schmitzova, J, Farnung, L, Siewert, A, Hoebartner, C, Cramer, P. | | 登録日 | 2020-11-30 | | 公開日 | 2020-12-23 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Mechanism of SARS-CoV-2 polymerase stalling by remdesivir.
Nat Commun, 12, 2021
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7B3C
 | | Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with Remdesivir at position -4 (structure 2) | | 分子名称: | DNA/RNA (5'-R(P*CP*UP*AP*CP*GP*CP*A)-D(P*(RMP))-R(P*GP*UP*G)-3'), Non-structural protein 7, Non-structural protein 8, ... | | 著者 | Kokic, G, Hillen, H.S, Tegunov, D, Dienemann, C, Seitz, F, Schmitzova, J, Farnung, L, Siewert, A, Hoebartner, C, Cramer, P. | | 登録日 | 2020-11-30 | | 公開日 | 2020-12-23 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Mechanism of SARS-CoV-2 polymerase stalling by remdesivir.
Nat Commun, 12, 2021
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7B0Y
 | | Structure of a transcribing RNA polymerase II-U1 snRNP complex | | 分子名称: | 145-nt RNA, DNA-directed RNA polymerase II subunit D, DNA-directed RNA polymerase II subunit E, ... | | 著者 | Zhang, S, Aibara, S, Vos, S.M, Agafonov, D.E, Luehrmann, R, Cramer, P. | | 登録日 | 2020-11-23 | | 公開日 | 2021-01-13 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structure of a transcribing RNA polymerase II-U1 snRNP complex.
Science, 371, 2021
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1RO0
 | | Bifunctional DNA primase/polymerase domain of ORF904 from the archaeal plasmid pRN1- Triple mutant F50M/L107M/L110M SeMet remote | | 分子名称: | ORF904, ZINC ION | | 著者 | Lipps, G, Weinzierl, A.O, von Scheven, G, Buchen, C, Cramer, P. | | 登録日 | 2003-12-01 | | 公開日 | 2004-01-27 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure of a bifunctional DNA primase-polymerase
Nat.Struct.Mol.Biol., 11, 2004
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7B7U
 | | Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2 | | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB3, ... | | 著者 | Fianu, I, Dienemann, C, Aibara, S, Schilbach, S, Cramer, P. | | 登録日 | 2020-12-11 | | 公開日 | 2021-05-19 | | 最終更新日 | 2024-11-20 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2.
Commun Biol, 4, 2021
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8P4B
 | | Structural insights into human co-transcriptional capping - structure 2 | | 分子名称: | DNA (35-MER), DNA (5'-D(P*AP*GP*CP*GP*GP*CP*GP*GP*AP*GP*CP*CP*AP*GP*CP*AP*GP*GP*GP*AP*GP*CP*TP*G)-3'), DNA-directed RNA polymerase II subunit E, ... | | 著者 | Garg, G, Dienemann, C, Farnung, L, Schwarz, J, Linden, A, Urlaub, H, Cramer, P. | | 登録日 | 2023-05-20 | | 公開日 | 2023-08-16 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural insights into human co-transcriptional capping.
Mol.Cell, 83, 2023
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8P4C
 | | Structural insights into human co-transcriptional capping - structure 3 | | 分子名称: | DNA (32-MER), DNA (41-MER), DNA-directed RNA polymerase II subunit E, ... | | 著者 | Garg, G, Dienemann, C, Farnung, L, Schwarz, J, Linden, A, Urlaub, H, Cramer, P. | | 登録日 | 2023-05-20 | | 公開日 | 2023-08-16 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural insights into human co-transcriptional capping.
Mol.Cell, 83, 2023
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8P4A
 | | Structural insights into human co-transcriptional capping - structure 1 | | 分子名称: | DNA (29-MER), DNA (38-MER), DNA-directed RNA polymerase II subunit E, ... | | 著者 | Garg, G, Dienemann, C, Farnung, L, Schwarz, J, Linden, A, Urlaub, H, Cramer, P. | | 登録日 | 2023-05-20 | | 公開日 | 2023-08-16 | | 最終更新日 | 2025-07-09 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural insights into human co-transcriptional capping.
Mol.Cell, 83, 2023
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8P4D
 | | Structural insights into human co-transcriptional capping - structure 4 | | 分子名称: | DNA (32-MER), DNA (41-MER), DNA-directed RNA polymerase II subunit E, ... | | 著者 | Garg, G, Dienemann, C, Farnung, L, Schwarz, J, Linden, A, Urlaub, H, Cramer, P. | | 登録日 | 2023-05-20 | | 公開日 | 2023-08-16 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural insights into human co-transcriptional capping.
Mol.Cell, 83, 2023
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8RAO
 | | Structure of Sen1-ADP.BeF3-RNA complex | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Helicase SEN1, ... | | 著者 | Rengachari, S, Lidscreiber, M, Cramer, P. | | 登録日 | 2023-12-01 | | 公開日 | 2024-10-30 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Mechanism of polyadenylation-independent RNA polymerase II termination.
Nat.Struct.Mol.Biol., 32, 2025
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8RAP
 | | Structure of Sen1-ADP.BeF3 bound RNA Polymerase II pre-termination complex | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA-directed RNA polymerase II subunit RPB1, ... | | 著者 | Rengachari, S, Lidscreiber, M, Cramer, P. | | 登録日 | 2023-12-01 | | 公開日 | 2024-10-30 | | 最終更新日 | 2025-02-26 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Mechanism of polyadenylation-independent RNA polymerase II termination.
Nat.Struct.Mol.Biol., 32, 2025
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8RAM
 | | Structure of Sen1 bound RNA Polymerase II pre-termination complex | | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | | 著者 | Rengachari, S, Lidscreiber, M, Cramer, P. | | 登録日 | 2023-12-01 | | 公開日 | 2024-10-30 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Mechanism of polyadenylation-independent RNA polymerase II termination.
Nat.Struct.Mol.Biol., 32, 2025
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8RAN
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1RNI
 | | Bifunctional DNA primase/polymerase domain of ORF904 from the archaeal plasmid pRN1 | | 分子名称: | ORF904, ZINC ION | | 著者 | Lipps, G, Weinzierl, A.O, von Scheven, G, Buchen, C, Cramer, P. | | 登録日 | 2003-12-01 | | 公開日 | 2004-01-27 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structure of a bifunctional DNA primase-polymerase
Nat.Struct.Mol.Biol., 11, 2004
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1Q1H
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1RO2
 | | Bifunctional DNA primase/polymerase domain of ORF904 from the archaeal plasmid pRN1- Triple mutant F50M/L107M/L110M manganese soak | | 分子名称: | MANGANESE (II) ION, ZINC ION, hypothetical protein ORF904 | | 著者 | Lipps, G, Weinzierl, A.O, von Scheven, G, Buchen, C, Cramer, P. | | 登録日 | 2003-12-01 | | 公開日 | 2004-01-27 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structure of a bifunctional DNA primase-polymerase
Nat.Struct.Mol.Biol., 11, 2004
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1T9Z
 | | Three-dimensional structure of a RNA-polymerase II binding protein. | | 分子名称: | CITRIC ACID, Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, MAGNESIUM ION | | 著者 | Kamenski, T, Heilmeier, S, Meinhart, A, Cramer, P. | | 登録日 | 2004-05-19 | | 公開日 | 2004-08-31 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure and Mechanism of
RNA Polymerase II CTD Phosphatases.
Mol.Cell, 15, 2004
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