4FXH
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3S7H
| Structure of thrombin mutant Y225P in the E* form | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Prothrombin | 著者 | Niu, W, Chen, Z, Gandhi, P, Vogt, A, Pozzi, N, Pele, L.A, Zapata, F, Di Cera, E. | 登録日 | 2011-05-26 | 公開日 | 2011-07-06 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystallographic and Kinetic Evidence of Allostery in a Trypsin-like Protease. Biochemistry, 50, 2011
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3S7K
| Structure of thrombin mutant Y225P in the E form | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, POTASSIUM ION, Prothrombin | 著者 | Niu, W, Chen, Z, Gandhi, P, Vogt, A, Pozzi, N, Pele, L.A, Zapata, F, Di Cera, E. | 登録日 | 2011-05-26 | 公開日 | 2011-07-06 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystallographic and Kinetic Evidence of Allostery in a Trypsin-like Protease. Biochemistry, 50, 2011
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7ODL
| SARS CoV-2 Spike protein, Bristol UK Deletion variant, Closed conformation, C1 symmetry | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, LINOLEIC ACID, Spike glycoprotein | 著者 | Toelzer, C, Gupta, K, Yadav, S.K.N, Borucu, U, Schaffitzel, C, Berger, I. | 登録日 | 2021-04-29 | 公開日 | 2022-01-26 | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | 主引用文献 | Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2. Nat Commun, 13, 2022
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3TDB
| Human Pin1 bound to trans peptidomimetic inhibitor | 分子名称: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, N-[(1E,2R)-1-[(2R)-2-{[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl}cyclopentylidene]-3-(phosphonooxy)propan-2-yl]-L-phenylalaninamide, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | 著者 | Zhang, M, Zhang, Y. | 登録日 | 2011-08-10 | 公開日 | 2012-06-27 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.267 Å) | 主引用文献 | Structural and Kinetic Analysis of Prolyl-isomerization/Phosphorylation Cross-Talk in the CTD Code. Acs Chem.Biol., 7, 2012
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3T6D
| Crystal Structure of the Reaction Centre from Blastochloris viridis strain DSM 133 (ATCC 19567) substrain-08 | 分子名称: | (2S,3R)-heptane-1,2,3-triol, 15-cis-1,2-dihydroneurosporene, BACTERIOCHLOROPHYLL B, ... | 著者 | Roszak, A.W, Gardiner, A.T, Isaacs, N.W, Cogdell, R.J. | 登録日 | 2011-07-28 | 公開日 | 2011-11-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | New insights into the structure of the reaction centre from Blastochloris viridis: evolution in the laboratory. Biochem.J., 442, 2012
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4IMJ
| Novel Modifications on C-terminal Domain of RNA Polymerase II can Fine-tune the Phosphatase Activity of Ssu72 | 分子名称: | CG14216, CTD, PHOSPHATE ION, ... | 著者 | Luo, Y, Yogesha, S.D, Zhang, Y. | 登録日 | 2013-01-03 | 公開日 | 2013-08-07 | 最終更新日 | 2013-10-23 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | Novel Modifications on C-terminal Domain of RNA Polymerase II Can Fine-tune the Phosphatase Activity of Ssu72. Acs Chem.Biol., 8, 2013
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4H1M
| Crystal structure of PYK2 with the indole 10c | 分子名称: | 7-({[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)-N-(propan-2-yl)-1H-indole-2-carboxamide, Protein-tyrosine kinase 2-beta | 著者 | Han, S. | 登録日 | 2012-09-10 | 公開日 | 2012-11-28 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
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4I1L
| Structural and Biological Features of FOXP3 Dimerization Relevant to Regulatory T Cell Function | 分子名称: | ACETATE ION, Forkhead box protein P3, MAGNESIUM ION, ... | 著者 | Song, X.M, Greene, M.I, Zhou, Z.C. | 登録日 | 2012-11-21 | 公開日 | 2012-12-05 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function. Cell Rep, 1, 2012
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4HXQ
| Crystal structure of human Arginase-1 complexed with inhibitor 14 | 分子名称: | Arginase-1, MANGANESE (II) ION, [(5R)-5-carboxy-5-(methylamino)-7-(piperidin-1-yl)heptyl](trihydroxy)borate(1-) | 著者 | Cousido-Siah, A, Mitschler, A, Ruiz, F.X, Whitehouse, D.L, Golebiowski, A, Ji, M, Zhang, M, Beckett, P, Sheeler, R, Andreoli, M, Conway, B, Mahboubi, K, Schroeter, H, Van Zandt, M.C, Podjarny, A. | 登録日 | 2012-11-12 | 公開日 | 2013-03-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury. J.Med.Chem., 56, 2013
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4HZE
| Crystal structure of human Arginase-2 complexed with inhibitor 9 | 分子名称: | Arginase-2, mitochondrial, BENZAMIDINE, ... | 著者 | Cousido-Siah, A, Mitschler, A, Ruiz, F.X, Whitehouse, D.L, Golebiowski, A, Ji, M, Zhang, M, Beckett, P, Sheeler, R, Andreoli, M, Conway, B, Mahboubi, K, Schroeter, H, Van Zandt, M.C, Podjarny, A. | 登録日 | 2012-11-15 | 公開日 | 2013-03-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.602 Å) | 主引用文献 | Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury. J.Med.Chem., 56, 2013
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3QK6
| Crystal structure of Escherichia coli PhnD | 分子名称: | PhnD, subunit of alkylphosphonate ABC transporter, UNKNOWN LIGAND | 著者 | Alicea, I, Schreiter, E.R. | 登録日 | 2011-01-31 | 公開日 | 2011-10-12 | 最終更新日 | 2011-12-21 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure of the Escherichia coli Phosphonate Binding Protein PhnD and Rationally Optimized Phosphonate Biosensors. J.Mol.Biol., 414, 2011
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3QGN
| The allosteric E*-E equilibrium is a key property of the trypsin fold | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, IODIDE ION, ... | 著者 | Niu, W, Gohara, D, Chen, Z, Di Cera, E. | 登録日 | 2011-01-24 | 公開日 | 2011-07-06 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystallographic and kinetic evidence of allostery in a trypsin-like protease. Biochemistry, 50, 2011
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3QA2
| X-ray Structure of ketohexokinase in complex with a pyrimidopyrimidine analog 2 | 分子名称: | Ketohexokinase, N~8~-(cyclopropylmethyl)-N~4~-(2-methylphenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine, SULFATE ION | 著者 | Abad, M.C. | 登録日 | 2011-01-10 | 公開日 | 2012-01-18 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.519 Å) | 主引用文献 | Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. ACS Med Chem Lett, 2, 2011
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3TWD
| glmuC1 in complex with an antibacterial inhibitor | 分子名称: | 4-({5-[(4-aminophenyl)(phenyl)sulfamoyl]-2,4-dimethoxyphenyl}amino)-4-oxobutanoic acid, Bifunctional protein glmU, SULFATE ION | 著者 | Lahiri, S, Otterbein, L. | 登録日 | 2011-09-21 | 公開日 | 2011-10-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | In Vitro Validation of Acetyltransferase Activity of GlmU as an Antibacterial Target in Haemophilus influenzae. J.Biol.Chem., 286, 2011
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4IMI
| Novel Modifications on C-terminal Domain of RNA Polymerase II can Fine- tune the Phosphatase Activity of Ssu72. | 分子名称: | CG14216, CTD, PHOSPHATE ION, ... | 著者 | Luo, Y, Yogesha, S.D, Zhang, Y. | 登録日 | 2013-01-03 | 公開日 | 2013-08-07 | 最終更新日 | 2013-10-30 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Novel Modifications on C-terminal Domain of RNA Polymerase II Can Fine-tune the Phosphatase Activity of Ssu72. Acs Chem.Biol., 8, 2013
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3U0D
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3SW8
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3SVJ
| Strep Peptide Deformylase with a time dependent thiazolidine amide | 分子名称: | (4R)-3-(4-[4-(2-chlorophenyl)piperazin-1-yl]-6-{[2-methyl-6-(methylcarbamoyl)phenyl]amino}-1,3,5-triazin-2-yl)-N-methyl-1,3-thiazolidine-4-carboxamide, GLYCEROL, NICKEL (II) ION, ... | 著者 | Campobasso, N, Ward, P. | 登録日 | 2011-07-12 | 公開日 | 2011-07-27 | 最終更新日 | 2014-11-12 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Understanding the origins of time-dependent inhibition by polypeptide deformylase inhibitors. Biochemistry, 50, 2011
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4I06
| Crystal structure of human Arginase-2 complexed with inhibitor 14 | 分子名称: | Arginase-2, mitochondrial, BENZAMIDINE, ... | 著者 | Cousido-Siah, A, Mitschler, A, Ruiz, F.X, Whitehouse, D.L, Golebiowski, A, Ji, M, Zhang, M, Beckett, P, Sheeler, R, Andreoli, M, Conway, B, Mahboubi, K, Schroeter, H, Van Zandt, M.C, Podjarny, A. | 登録日 | 2012-11-16 | 公開日 | 2013-03-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury. J.Med.Chem., 56, 2013
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3U9P
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4JPB
| The structure of a ternary complex between CheA domains P4 and P5 with CheW and with an unzipped fragment of TM14, a chemoreceptor analog from Thermotoga maritima. | 分子名称: | Chemotaxis protein CheA, Chemotaxis protein CheW, Methyl-accepting chemotaxis protein | 著者 | Li, X, Bayas, C, Bilwes, A.M, Crane, B.R. | 登録日 | 2013-03-19 | 公開日 | 2013-08-28 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.186 Å) | 主引用文献 | The 3.2 angstrom resolution structure of a receptor: CheA:CheW signaling complex defines overlapping binding sites and key residue interactions within bacterial chemosensory arrays. Biochemistry, 52, 2013
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4FZ4
| Crystal structure of HP0197-18kd | 分子名称: | CHLORIDE ION, NITRATE ION, Uncharacterized protein conserved in bacteria | 著者 | Yuan, Z, Yan, X. | 登録日 | 2012-07-06 | 公開日 | 2012-12-05 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | Molecular mechanism by which surface antigen HP0197 mediates host cell attachment in the pathogenic bacteria Streptococcus suis J.Biol.Chem., 288, 2013
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4FZQ
| Crystal structure of HP0197-G5 | 分子名称: | Uncharacterized protein conserved in bacteria | 著者 | Yuan, Z, Yan, X. | 登録日 | 2012-07-07 | 公開日 | 2012-12-05 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Molecular mechanism by which surface antigen HP0197 mediates host cell attachment in the pathogenic bacteria Streptococcus suis J.Biol.Chem., 288, 2013
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3TCZ
| Human Pin1 bound to cis peptidomimetic inhibitor | 分子名称: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, N~2~-({(1R,2Z)-2-[(2R)-2-(formylamino)-3-(phosphonooxy)propylidene]cyclopentyl}carbonyl)-L-argininamide, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | 著者 | Zhang, M, Zhang, Y. | 登録日 | 2011-08-09 | 公開日 | 2012-06-20 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural and Kinetic Analysis of Prolyl-isomerization/Phosphorylation Cross-Talk in the CTD Code. Acs Chem.Biol., 7, 2012
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