4JRG
| The 1.9A crystal structure of humanized Xenopus MDM2 with RO5313109 - a pyrrolidine MDM2 inhibitor | 分子名称: | (3R,4R,5S)-3-(3-chlorophenyl)-4-(4-chlorophenyl)-4-cyano-N-[(3S)-3,4-dihydroxybutyl]-5-(2,2-dimethylpropyl)-D-prolinamide, E3 ubiquitin-protein ligase Mdm2 | 著者 | Graves, B.J, Janson, C.A, Lukacs, C. | 登録日 | 2013-03-21 | 公開日 | 2013-07-24 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of RG7388, a Potent and Selective p53-MDM2 Inhibitor in Clinical Development. J.Med.Chem., 56, 2013
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3SRU
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5DRT
| Crystal structure of Dot1L in complex with inhibitor CPD2 [2-(2-(5-((2-chlorophenoxy)methyl)-1H-tetrazol-1-yl)acetyl)-N-(4-chlorophenyl)hydrazinecarboxamide] | 分子名称: | 2-({5-[(2-chlorophenoxy)methyl]-1H-tetrazol-1-yl}acetyl)-N-(4-chlorophenyl)hydrazinecarboxamide, Histone-lysine N-methyltransferase, H3 lysine-79 specific, ... | 著者 | Scheufler, C, Gaul, C, Be, C, Moebitz, H. | 登録日 | 2015-09-16 | 公開日 | 2016-06-15 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach. Acs Med.Chem.Lett., 7, 2016
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6KVE
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6LHC
| The cryo-EM structure of coxsackievirus A16 empty particle | 分子名称: | VP1, VP2, VP3 | 著者 | He, M.Z, Xu, L.F, Zheng, Q.B, Zhu, R, Yin, Z.C, Cheng, T, Li, S.W. | 登録日 | 2019-12-07 | 公開日 | 2020-02-05 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.43 Å) | 主引用文献 | Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16. Cell Host Microbe, 27, 2020
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6LHL
| The cryo-EM structure of coxsackievirus A16 A-particle in complex with Fab 18A7 | 分子名称: | VP1 protein, VP2 protein, VP3 protein | 著者 | He, M.Z, Xu, L.F, Zheng, Q.B, Zhu, R, Yin, Z.C, Cheng, T, Li, S.W. | 登録日 | 2019-12-09 | 公開日 | 2020-02-05 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16. Cell Host Microbe, 27, 2020
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6LHB
| The cryo-EM structure of coxsackievirus A16 A-particle | 分子名称: | VP1, VP2, VP3 | 著者 | He, M.Z, Xu, L.F, Zheng, Q.B, Zhu, R, Yin, Z.C, Cheng, T, Li, S.W. | 登録日 | 2019-12-07 | 公開日 | 2020-02-05 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | 主引用文献 | Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16. Cell Host Microbe, 27, 2020
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6LHP
| The cryo-EM structure of coxsackievirus A16 mature virion in complex with Fab 14B10 | 分子名称: | SPHINGOSINE, VP1 protein, VP2 protein, ... | 著者 | He, M.Z, Xu, L.F, Zheng, Q.B, Zhu, R, Yin, Z.C, Cheng, T, Li, S.W. | 登録日 | 2019-12-09 | 公開日 | 2020-02-05 | 最終更新日 | 2020-02-26 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16. Cell Host Microbe, 27, 2020
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6KVH
| The mutant crystal structure of endo-polygalacturonase (T284A) from Talaromyces leycettanus JCM 12802 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose, endo-polygalacturonase | 著者 | Tu, T, Wang, Z, Luo, H, Yao, B. | 登録日 | 2019-09-04 | 公開日 | 2020-09-09 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Structural Insights into the Mechanisms Underlying the Kinetic Stability of GH28 Endo-Polygalacturonase. J.Agric.Food Chem., 69, 2021
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3V43
| Crystal structure of MOZ | 分子名称: | ACETATE ION, Histone H3.1, Histone acetyltransferase KAT6A, ... | 著者 | Qiu, Y, Li, F. | 登録日 | 2011-12-14 | 公開日 | 2012-06-27 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription Genes Dev., 26, 2012
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4LWT
| The 1.6A Crystal Structure of Humanized Xenopus MDM2 with RO5027344 | 分子名称: | (3S)-3-[(3R)-1-acetylpiperidin-3-yl]-6-chloro-3-(3-chlorobenzyl)-1,3-dihydro-2H-indol-2-one, E3 ubiquitin-protein ligase Mdm2, SULFATE ION | 著者 | Graves, B.J, Lukacs, C, Kammlott, U. | 登録日 | 2013-07-28 | 公開日 | 2014-07-16 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy. Bioorg.Med.Chem., 22, 2014
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5XK0
| Structure of 8-mer DNA2 | 分子名称: | DNA (5'-D(*GP*CP*CP*CP*GP*AP*GP*C)-3') | 著者 | Liu, H.H, Gan, J.H. | 登録日 | 2017-05-04 | 公開日 | 2017-12-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.451 Å) | 主引用文献 | A DNA Structure Containing AgI -Mediated G:G and C:C Base Pairs Angew. Chem. Int. Ed. Engl., 56, 2017
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5XS5
| Structure of Coxsackievirus A6 (CVA6) virus procapsid particle | 分子名称: | Genome polyprotein | 著者 | Zheng, Q.B, He, M.Z, Xu, L.F, Yu, H, Cheng, T, Li, S.W. | 登録日 | 2017-06-12 | 公開日 | 2017-09-27 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody Nat Commun, 8, 2017
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4LWU
| The 1.14A Crystal Structure of Humanized Xenopus MDM2 with RO5499252 | 分子名称: | (2'S,3R,4'S,5'R)-N-(4-carbamoylphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide, E3 ubiquitin-protein ligase Mdm2, SULFATE ION | 著者 | Graves, B.J, Lukacs, C, Janson, C.A. | 登録日 | 2013-07-28 | 公開日 | 2014-07-16 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.14 Å) | 主引用文献 | Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy. Bioorg.Med.Chem., 22, 2014
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6M02
| cryo-EM structure of human Pannexin 1 channel | 分子名称: | Pannexin-1 | 著者 | Ronggui, Q, Lili, D, Jilin, Z, Xuekui, Y, Lei, W, Shujia, Z. | 登録日 | 2020-02-19 | 公開日 | 2020-03-25 | 最終更新日 | 2020-05-27 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM structure of human heptameric Pannexin 1 channel. Cell Res., 30, 2020
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7EBK
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8G4U
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6MYL
| The Prp8 intein-cisplatin complex | 分子名称: | PLATINUM (II) ION, Pre-mRNA-processing-splicing factor 8 | 著者 | Li, Z, Li, H. | 登録日 | 2018-11-01 | 公開日 | 2019-11-06 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.06 Å) | 主引用文献 | Cisplatin protects mice from challenge ofCryptococcus neoformansby targeting the Prp8 intein. Emerg Microbes Infect, 8, 2019
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8GKA
| Human TRPV3 tetramer structure, closed conformation | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3 | 著者 | Lansky, S, Betancourt, J.M, Scheuring, S. | 登録日 | 2023-03-17 | 公開日 | 2023-09-06 | 最終更新日 | 2023-09-20 | 実験手法 | ELECTRON MICROSCOPY (2.55 Å) | 主引用文献 | A pentameric TRPV3 channel with a dilated pore. Nature, 621, 2023
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8GKG
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8HAW
| An auto-activation mechanism of plant non-specific phospholipase C | 分子名称: | CALCIUM ION, GLYCEROL, Non-specific phospholipase C4, ... | 著者 | Zhao, F, Fan, R.Y, Guan, Z.Y, Guo, L, Yin, P. | 登録日 | 2022-10-26 | 公開日 | 2023-01-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Insights into the mechanism of phospholipid hydrolysis by plant non-specific phospholipase C. Nat Commun, 14, 2023
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8HAV
| An auto-activation mechanism of plant non-specific phospholipase C | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Non-specific phospholipase C4 | 著者 | Zhao, F, Fan, R.Y, Guan, Z.Y, Guo, L, Yin, P. | 登録日 | 2022-10-26 | 公開日 | 2023-01-25 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Insights into the mechanism of phospholipid hydrolysis by plant non-specific phospholipase C. Nat Commun, 14, 2023
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8H3X
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8H3Y
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8HQ8
| Bry-LHCII homotrimer of Bryopsis corticulans | 分子名称: | (1R,3R)-6-{(3E,5E,7E,9E,11E,13E,15E,17E)-18-[(1S,4R,6R)-4-HYDROXY-2,2,6-TRIMETHYL-7-OXABICYCLO[4.1.0]HEPT-1-YL]-3,7,12,16-TETRAMETHYLOCTADECA-1,3,5,7,9,11,13,15,17-NONAENYLIDENE}-1,5,5-TRIMETHYLCYCLOHEXANE-1,3-DIOL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ... | 著者 | Li, Z.H, Shen, J.R, Wang, W.D. | 登録日 | 2022-12-13 | 公開日 | 2023-09-06 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural and functional properties of different types of siphonous LHCII trimers from an intertidal green alga Bryopsis corticulans. Structure, 31, 2023
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