4LWT

The 1.6A Crystal Structure of Humanized Xenopus MDM2 with RO5027344

Summary for 4LWT

Entry DOI	10.2210/pdb4lwt/pdb
Related	4LWU 4LWV
Descriptor	E3 ubiquitin-protein ligase Mdm2, (3S)-3-[(3R)-1-acetylpiperidin-3-yl]-6-chloro-3-(3-chlorobenzyl)-1,3-dihydro-2H-indol-2-one, SULFATE ION, ... (4 entities in total)
Functional Keywords	mdm2, indolinone, e3 ubiquitin ligase, p53, nucleus, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological source	Xenopus laevis (clawed frog,common platanna,platanna)
Cellular location	Nucleus, nucleoplasm (By similarity): P56273
Total number of polymer chains	1
Total formula weight	10476.01
Authors	Graves, B.J.,Lukacs, C.,Kammlott, U. (deposition date: 2013-07-28, release date: 2014-07-16, Last modification date: 2024-02-28)
Primary citation	Zhang, Z.,Ding, Q.,Liu, J.J.,Zhang, J.,Jiang, N.,Chu, X.J.,Bartkovitz, D.,Luk, K.C.,Janson, C.,Tovar, C.,Filipovic, Z.M.,Higgins, B.,Glenn, K.,Packman, K.,Vassilev, L.T.,Graves, B. Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy. Bioorg.Med.Chem., 22:4001-4009, 2014 Cited by PubMed: 24997575 DOI: 10.1016/j.bmc.2014.05.072 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation