6L8R
| membrane-bound PD-L1-CD | 分子名称: | Programmed cell death 1 ligand 1 | 著者 | Maorong, W, Cao, Y, Bin, W, Bo, O. | 登録日 | 2019-11-07 | 公開日 | 2020-11-11 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain. Nat Commun, 12, 2021
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6LYP
| Cryo-EM structure of AtMSL1 wild type | 分子名称: | Mechanosensitive ion channel protein 1, mitochondrial | 著者 | Sun, L. | 登録日 | 2020-02-15 | 公開日 | 2020-04-15 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural Insights into a Plant Mechanosensitive Ion Channel MSL1. Cell Rep, 30, 2020
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6N7B
| Structure of the human JAK1 kinase domain with compound 38 | 分子名称: | GLYCEROL, N-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-yl]-1H-pyrazolo[4,3-c]pyridine-7-carboxamide, Tyrosine-protein kinase JAK1 | 著者 | Lupardus, P.J, Brown, D. | 登録日 | 2018-11-27 | 公開日 | 2019-04-24 | 最終更新日 | 2019-05-15 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling. Bioorg.Med.Chem.Lett., 29, 2019
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6N79
| Structure of the human JAK1 kinase domain with compound 20 | 分子名称: | GLYCEROL, N-{5-[5-chloro-2-(difluoromethoxy)phenyl]-1H-pyrazol-4-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide, Tyrosine-protein kinase JAK1 | 著者 | Lupardus, P.J, Brown, D. | 登録日 | 2018-11-27 | 公開日 | 2019-04-24 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling. Bioorg.Med.Chem.Lett., 29, 2019
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6N3N
| Identification of novel, potent and selective GCN2 inhibitors as first-in-class anti-tumor agents | 分子名称: | N-{3-[(2-aminopyrimidin-5-yl)ethynyl]-2,4-difluorophenyl}-2,5-dichloro-3-(hydroxymethyl)benzene-1-sulfonamide, eIF-2-alpha kinase GCN2,eIF-2-alpha kinase GCN2 | 著者 | Hoffman, I.D, Fujimoto, J, Kurasawa, O, Takagi, T, Klein, M.G, Kefala, G, Ding, S.C, Cary, D.R, Mizojiri, R. | 登録日 | 2018-11-15 | 公開日 | 2019-10-09 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | 主引用文献 | Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode. Acs Med.Chem.Lett., 10, 2019
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6N7C
| Structure of the human JAK1 kinase domain with compound 56 | 分子名称: | GLYCEROL, N-[5-(3-methoxynaphthalen-2-yl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, Tyrosine-protein kinase JAK1 | 著者 | Lupardus, P.J, Brown, D. | 登録日 | 2018-11-27 | 公開日 | 2019-04-24 | 最終更新日 | 2019-05-15 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling. Bioorg.Med.Chem.Lett., 29, 2019
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6N78
| Structure of the human JAK1 kinase domain with compound 21 | 分子名称: | GLYCEROL, N-{3-[5-chloro-2-(difluoromethoxy)phenyl]-1-methyl-1H-pyrazol-4-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide, Tyrosine-protein kinase JAK1 | 著者 | Lupardus, P.J, Brown, D. | 登録日 | 2018-11-27 | 公開日 | 2019-04-24 | 最終更新日 | 2019-05-15 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling. Bioorg.Med.Chem.Lett., 29, 2019
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6N7A
| Structure of the human JAK1 kinase domain with compound 39 | 分子名称: | GLYCEROL, N-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-yl]-2-methyl-2H-pyrazolo[4,3-c]pyridine-7-carboxamide, Tyrosine-protein kinase JAK1 | 著者 | Lupardus, P.J, Brown, D. | 登録日 | 2018-11-27 | 公開日 | 2019-04-24 | 最終更新日 | 2019-05-15 | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | 主引用文献 | Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling. Bioorg.Med.Chem.Lett., 29, 2019
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7YEU
| Superfolder green fluorescent protein with phosphine unnatural amino acid P3BF | 分子名称: | Superfolder green fluorescent protein | 著者 | Hu, C, Duan, H.Z, Liu, X.H, Chen, Y.X, Wang, J.Y. | 登録日 | 2022-07-06 | 公開日 | 2023-07-26 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Genetically Encoded Phosphine Ligand for Metalloprotein Design. J.Am.Chem.Soc., 144, 2022
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6N77
| Structure of the human JAK1 kinase domain with compound 15 | 分子名称: | GLYCEROL, N-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, Tyrosine-protein kinase JAK1 | 著者 | Lupardus, P.J, Brown, D. | 登録日 | 2018-11-27 | 公開日 | 2019-04-24 | 最終更新日 | 2019-05-15 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling. Bioorg.Med.Chem.Lett., 29, 2019
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6N7D
| Structure of the human JAK1 kinase domain with compound 54 | 分子名称: | GLYCEROL, N-[5-(6-methoxy-1H-indazol-5-yl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, Tyrosine-protein kinase JAK1 | 著者 | Lupardus, P.J, Brown, D. | 登録日 | 2018-11-27 | 公開日 | 2019-04-24 | 最終更新日 | 2019-05-15 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling. Bioorg.Med.Chem.Lett., 29, 2019
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6N3O
| Identification of novel, potent and selective GCN2 inhibitors as first-in-class anti-tumor agents | 分子名称: | N-{3-[(2-aminopyrimidin-5-yl)ethynyl]-2,4-difluorophenyl}-5-chloro-2-methoxypyridine-3-sulfonamide, eIF-2-alpha kinase GCN2 | 著者 | Hoffman, I.D, Fujimoto, J, Kurasawa, O, Takagi, T, Klein, M.G, Kefala, G, Ding, S.C, Cary, D.R, Mizojiri, R. | 登録日 | 2018-11-15 | 公開日 | 2019-10-09 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode. Acs Med.Chem.Lett., 10, 2019
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8IQU
| Structure of MtbFadD23 with PhU-AMS | 分子名称: | 5'-O-[(11-phenoxyundecanoyl)sulfamoyl]adenosine, Fatty-acid-CoA ligase FadD23 | 著者 | Yan, M.R, Zhang, W. | 登録日 | 2023-03-17 | 公開日 | 2023-04-26 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | Structural basis for the development of potential inhibitors targeting FadD23 from Mycobacterium tuberculosis. Acta Crystallogr.,Sect.F, 79, 2023
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6N3L
| Identification of novel, potent and selective GCN2 inhibitors as first-in-class anti-tumor agents | 分子名称: | N-{6-[(1-methyl-2-{[4-(trifluoromethyl)phenyl]amino}-1H-benzimidazol-5-yl)oxy]pyrimidin-4-yl}cyclopropanecarboxamide, eIF-2-alpha kinase GCN2,eIF-2-alpha kinase GCN2 | 著者 | Hoffman, I.D, Fujimoto, J, Kurasawa, O, Takagi, T, Klein, M.G, Kefala, G, Ding, S.C, Cary, D.R, Mizojiri, R. | 登録日 | 2018-11-15 | 公開日 | 2019-10-09 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode. Acs Med.Chem.Lett., 10, 2019
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6NE7
| Structure of G810A mutant of RET protein tyrosine kinase domain. | 分子名称: | ADENOSINE MONOPHOSPHATE, FORMIC ACID, Proto-oncogene tyrosine-protein kinase receptor Ret | 著者 | Terzyan, S.S, Shen, T, Wu, J, Mooers, B.H.M. | 登録日 | 2018-12-17 | 公開日 | 2019-06-05 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib. J.Biol.Chem., 294, 2019
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7WJQ
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3NYL
| The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain | 分子名称: | Amyloid beta (A4) protein (Peptidase nexin-II, Alzheimer disease), isoform CRA_b | 著者 | Ha, Y, Hu, J, Lee, S, Liu, X, Wang, Y. | 登録日 | 2010-07-15 | 公開日 | 2011-07-13 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain. Mol.Cell, 15, 2004
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5Y4G
| Apo Structure of AmbP3 | 分子名称: | AmbP3 | 著者 | Wong, C.P, Awakawa, T, Nakashima, Y. | 登録日 | 2017-08-03 | 公開日 | 2018-07-18 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Two Distinct Substrate Binding Modes for the Normal and Reverse Prenylation of Hapalindoles by the Prenyltransferase AmbP3 Angew. Chem. Int. Ed. Engl., 57, 2018
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5JLY
| Structure of Peroxiredoxin-1 from Schistosoma japonicum | 分子名称: | Thioredoxin peroxidase-1 | 著者 | Wu, Q, Huang, F, Zeng, D, Liu, X, Zhao, J, Wang, H, Peng, Y, Li, P, Li, Y. | 登録日 | 2016-04-27 | 公開日 | 2017-05-03 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.051 Å) | 主引用文献 | Crystal structure of Peroxiredoxin-1 from Schistosoma japonicum To Be Published
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5Y72
| DMSPP Bound AmbP3 | 分子名称: | AmbP3, DIMETHYLALLYL S-THIOLODIPHOSPHATE | 著者 | Wong, C.P, Awakawa, T, Nakashima, Y. | 登録日 | 2017-08-16 | 公開日 | 2018-07-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Two Distinct Substrate Binding Modes for the Normal and Reverse Prenylation of Hapalindoles by the Prenyltransferase AmbP3 Angew. Chem. Int. Ed. Engl., 57, 2018
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5Y84
| Hapalindole U and DMSPP Bound AmbP3 | 分子名称: | AmbP3, DIMETHYLALLYL S-THIOLODIPHOSPHATE, Hapalindole U | 著者 | Wong, C.P, Awakawa, T, Nakashima, Y. | 登録日 | 2017-08-18 | 公開日 | 2018-07-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Two Distinct Substrate Binding Modes for the Normal and Reverse Prenylation of Hapalindoles by the Prenyltransferase AmbP3 Angew. Chem. Int. Ed. Engl., 57, 2018
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5Y7C
| Hapalindole A and DMSPP Bound AmbP3 | 分子名称: | AmbP3, DIMETHYLALLYL S-THIOLODIPHOSPHATE, Hapalindole A | 著者 | Wong, C.P, Awakawa, T, Nakashima, Y. | 登録日 | 2017-08-16 | 公開日 | 2018-07-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.003 Å) | 主引用文献 | Two Distinct Substrate Binding Modes for the Normal and Reverse Prenylation of Hapalindoles by the Prenyltransferase AmbP3 Angew. Chem. Int. Ed. Engl., 57, 2018
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5WRO
| Crystal structure of Drosophila enolase | 分子名称: | CADMIUM ION, CHLORIDE ION, COBALT (II) ION, ... | 著者 | Zhang, Z, Shi, Z. | 登録日 | 2016-12-02 | 公開日 | 2017-04-26 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.015 Å) | 主引用文献 | Crystal structure of enolase from Drosophila melanogaster. Acta Crystallogr F Struct Biol Commun, 73, 2017
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5WDJ
| CRYSTAL STRUCTURE OF MYELOPEROXIDASE SUBFORM C (MPO) COMPLEX WITH COMPOUND-6 AKA 7-(BENZYLOXY)-1H-[1,2, 3]TRIAZOLO[4,5-D]PYRIMIDIN-5-AMINE | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 7-(benzyloxy)-1H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine, CALCIUM ION, ... | 著者 | Khan, J.A. | 登録日 | 2017-07-05 | 公開日 | 2018-04-18 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Triazolopyrimidines identified as reversible myeloperoxidase inhibitors. Medchemcomm, 8, 2017
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5WZX
| Structural basis for a pentacyclic oleanane-type triterpenoid as a ligand of FXR | 分子名称: | (4aR,6aR,6aS,6bS,8aS,9R,12aR,14bR)-2,2,6a,6b,9,12a-hexamethyl-10-oxidanylidene-1,3,4,5,6,6a,7,8,8a,9,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid, (R,R)-2,3-BUTANEDIOL, Bile acid receptor, ... | 著者 | Lu, Y, Li, Y. | 登録日 | 2017-01-19 | 公開日 | 2018-01-03 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Identification of an Oleanane-Type Triterpene Hedragonic Acid as a Novel Farnesoid X Receptor Ligand with Liver Protective Effects and Anti-inflammatory Activity Mol. Pharmacol., 93, 2018
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