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6N79

Structure of the human JAK1 kinase domain with compound 20

Summary for 6N79
Entry DOI10.2210/pdb6n79/pdb
DescriptorTyrosine-protein kinase JAK1, N-{5-[5-chloro-2-(difluoromethoxy)phenyl]-1H-pyrazol-4-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide, GLYCEROL, ... (4 entities in total)
Functional Keywordsjak1, il13, il-13, jak2, jak3, tyk2, immune system
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight35243.45
Authors
Lupardus, P.J.,Brown, D. (deposition date: 2018-11-27, release date: 2019-04-24, Last modification date: 2019-05-15)
Primary citationZak, M.,Hanan, E.J.,Lupardus, P.,Brown, D.G.,Robinson, C.,Siu, M.,Lyssikatos, J.P.,Romero, F.A.,Zhao, G.,Kellar, T.,Mendonca, R.,Ray, N.C.,Goodacre, S.C.,Crackett, P.H.,McLean, N.,Hurley, C.A.,Yuen, P.W.,Cheng, Y.X.,Liu, X.,Liimatta, M.,Kohli, P.B.,Nonomiya, J.,Salmon, G.,Buckley, G.,Lloyd, J.,Gibbons, P.,Ghilardi, N.,Kenny, J.R.,Johnson, A.
Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling.
Bioorg.Med.Chem.Lett., 29:1522-1531, 2019
Cited by
PubMed: 30981576
DOI: 10.1016/j.bmcl.2019.04.008
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.27 Å)
Structure validation

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