5OVH
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![BU of 5ovh by Molmil](/molmil-images/mine/5ovh) | Ras guanine nucleotide exchange factor SOS1 (Rem-cdc25) in complex with small molecule inhibitor compound 21 | 分子名称: | 1,2-ETHANEDIOL, Son of sevenless homolog 1, [2-[5-[(1~{R})-1-[(6,7-dimethoxy-2-methyl-5,8-dihydroquinazolin-4-yl)amino]ethyl]thiophen-2-yl]phenyl]methanol | 著者 | Hillig, R.C, Sautier, B, Schroeder, J, Moosmayer, D, Hilpmann, A, Stegmann, C.M, Briem, H, Boemer, U, Weiske, J, Badock, V, Petersen, K, Kahmann, J, Wegener, D, Bohnke, N, Eis, K, Graham, K, Wortmann, L, von Nussbaum, F, Bader, B. | 登録日 | 2017-08-28 | 公開日 | 2019-02-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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5ZKN
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3GUR
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![BU of 3gur by Molmil](/molmil-images/mine/3gur) | Crystal Structure of mu class glutathione S-transferase (GSTM2-2) in complex with glutathione and 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) | 分子名称: | 1,2-ETHANEDIOL, GLUTATHIONE, Glutathione S-transferase Mu 2, ... | 著者 | Federici, L, Lo Sterzo, C, Di Matteo, A, Scaloni, F, Federici, G, Caccuri, A.M. | 登録日 | 2009-03-30 | 公開日 | 2009-10-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis for the binding of the anticancer compound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione s-transferases Cancer Res., 69, 2009
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3H1S
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![BU of 3h1s by Molmil](/molmil-images/mine/3h1s) | Crystal structure of superoxide dismutase from Francisella tularensis subsp. tularensis SCHU S4 | 分子名称: | FE (III) ION, GLYCEROL, Superoxide dismutase | 著者 | Nocek, B, Zhou, M, Papazisi, L, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2009-04-13 | 公開日 | 2009-05-05 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of superoxide dismutase from Francisella tularensis subsp. tularensis SCHU S4 To be Published
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7YX3
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![BU of 7yx3 by Molmil](/molmil-images/mine/7yx3) | Structure of the Mimivirus genomic fibre in its compact 6-start helix form | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Putative GMC-type oxidoreductase | 著者 | Villalta, A, Schmitt, A, Estrozi, L.F, Quemin, E.R.J, Alempic, J.M, Lartigue, A, Prazak, V, Belmudes, L, Vasishtan, D, Colmant, A.M.G, Honore, F.A, Coute, Y, Grunewald, K, Abergel, C. | 登録日 | 2022-02-15 | 公開日 | 2022-08-10 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | The giant mimivirus 1.2 Mb genome is elegantly organized into a 30-nm diameter helical protein shield. Elife, 11, 2022
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3H8B
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![BU of 3h8b by Molmil](/molmil-images/mine/3h8b) | A combined crystallographic and molecular dynamics study of cathepsin-L retro-binding inhibitors(compound 9) | 分子名称: | Cathepsin L1, N~2~,N~6~-bis(biphenyl-4-ylacetyl)-L-lysyl-D-arginyl-N-(2-phenylethyl)-L-phenylalaninamide | 著者 | Tulsidas, S.R, Chowdhury, S.F, Kumar, S, Joseph, L, Purisima, E.O, Sivaraman, J. | 登録日 | 2009-04-29 | 公開日 | 2009-10-20 | 最終更新日 | 2014-02-05 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A combined crystallographic and molecular dynamics study of cathepsin L retrobinding inhibitors J.Med.Chem., 52, 2009
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5ORH
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![BU of 5orh by Molmil](/molmil-images/mine/5orh) | The crystal structure of CK2alpha in complex with compound 2 | 分子名称: | ACETATE ION, Casein kinase II subunit alpha, [3-chloranyl-4-(2-methylphenyl)phenyl]methanamine | 著者 | Brear, P, De Fusco, C, Iegre, J, Yoshida, M, Mitchell, S, Rossmann, M, Carro, L, Sore, H, Hyvonen, M, Spring, D. | 登録日 | 2017-08-16 | 公開日 | 2018-02-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Second-generation CK2 alpha inhibitors targeting the alpha D pocket. Chem Sci, 9, 2018
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3H0X
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![BU of 3h0x by Molmil](/molmil-images/mine/3h0x) | Crystal structure of peptide-binding domain of Kar2 protein from Saccharomyces cerevisiae | 分子名称: | 78 kDa glucose-regulated protein homolog | 著者 | Osipiuk, J, Bigelow, L, Gu, M, Sahi, C, Craig, E.A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2009-04-10 | 公開日 | 2009-04-21 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | X-ray crystal structure of peptide-binding domain of Kar2 protein from Saccharomyces cerevisiae. To be Published
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3GLT
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![BU of 3glt by Molmil](/molmil-images/mine/3glt) | Crystal Structure of Human SIRT3 with ADPR bound to the AceCS2 peptide containing a thioacetyl lysine | 分子名称: | Acetyl-coenzyme A synthetase 2-like, mitochondrial, CARBONATE ION, ... | 著者 | Jin, L, Wei, W, Jiang, Y, Peng, H, Cai, J, Mao, C, Dai, H, Bemis, J.E, Jirousek, M.R, Milne, J.C, Westphal, C.H, Perni, R.B. | 登録日 | 2009-03-12 | 公開日 | 2009-06-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes. J.Biol.Chem., 284, 2009
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6RFT
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![BU of 6rft by Molmil](/molmil-images/mine/6rft) | Crystal structure of Eis2 from Mycobacterium abscessus bound to Acetyl-CoA | 分子名称: | ACETYL COENZYME *A, Uncharacterized N-acetyltransferase D2E36_21790 | 著者 | Blaise, M, Kremer, L, Olieric, V, Alsarraf, H, Ung, K.L. | 登録日 | 2019-04-16 | 公開日 | 2019-07-10 | 最終更新日 | 2019-11-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of the aminoglycosides N-acetyltransferase Eis2 from Mycobacterium abscessus. Febs J., 286, 2019
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5OT2
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![BU of 5ot2 by Molmil](/molmil-images/mine/5ot2) | RNA polymerase II elongation complex in the presence of 3d-Napht-A | 分子名称: | 2-ethyl-7-methoxy-naphthalene, DNA non-template strand, DNA template strand, ... | 著者 | Malvezzi, S, Farnung, L, Aloisi, C, Angelov, T, Cramer, P, Sturla, S.J. | 登録日 | 2017-08-19 | 公開日 | 2017-11-01 | 最終更新日 | 2019-07-10 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Mechanism of RNA polymerase II stalling by DNA alkylation. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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3GNZ
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![BU of 3gnz by Molmil](/molmil-images/mine/3gnz) | Toxin fold for microbial attack and plant defense | 分子名称: | 25 kDa protein elicitor, MAGNESIUM ION | 著者 | Ottmann, C, Luberacki, B, Kuefner, I, Koch, W, Brunner, F, Weyand, M, Mattinen, L, Pirhonen, M, Anderluh, G, Seitz, H.U, Nuernberger, T, Oecking, C. | 登録日 | 2009-03-18 | 公開日 | 2009-06-09 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | A common toxin fold mediates microbial attack and plant defense Proc.Natl.Acad.Sci.USA, 106, 2009
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5OVJ
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![BU of 5ovj by Molmil](/molmil-images/mine/5ovj) | Structure of the apo form of Mycobacterium smegmatis MabA | 分子名称: | 3-oxoacyl-[acyl-carrier-protein] reductase FabG, SULFATE ION | 著者 | Kussau, T, Van Wyk, N, Viljoen, A, Olieric, V, Flipo, M, Kremer, L, Blaise, M. | 登録日 | 2017-08-29 | 公開日 | 2018-02-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural rearrangements occurring upon cofactor binding in the Mycobacterium smegmatis beta-ketoacyl-acyl carrier protein reductase MabA. Acta Crystallogr D Struct Biol, 74, 2018
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6RKZ
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![BU of 6rkz by Molmil](/molmil-images/mine/6rkz) | Recombinant Pseudomonas stutzeri nitrous oxide reductase, form II | 分子名称: | (MU-4-SULFIDO)-TETRA-NUCLEAR COPPER ION, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ... | 著者 | Zhang, L, Wuest, A, Prasser, B, Mueller, C, Einsle, O. | 登録日 | 2019-04-30 | 公開日 | 2019-06-26 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.601 Å) | 主引用文献 | Functional assembly of nitrous oxide reductase provides insights into copper site maturation. Proc.Natl.Acad.Sci.USA, 116, 2019
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5Z9C
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5OVR
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6RLV
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![BU of 6rlv by Molmil](/molmil-images/mine/6rlv) | Trypanosoma brucei Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-sulfamoyl)N3-methyluridine | 分子名称: | 5'-O-(N-(L-seryl)-sulfamoyl)N3-methyluridine, GLYCEROL, MALONATE ION, ... | 著者 | Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D. | 登録日 | 2019-05-02 | 公開日 | 2020-01-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases. Acs Chem.Biol., 15, 2020
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5ZNU
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7ZE1
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![BU of 7ze1 by Molmil](/molmil-images/mine/7ze1) | Tribolium castaneum hexamerin 2 | 分子名称: | Larval serum protein 1 gamma chain-like Protein | 著者 | Valentova, L, Fuzik, T, Plevka, P. | 登録日 | 2022-03-30 | 公開日 | 2022-11-23 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Polyelectrolyte coating of cryo-EM grids improves lateral distribution and prevents aggregation of macromolecules. Acta Crystallogr D Struct Biol, 78, 2022
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5OY9
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![BU of 5oy9 by Molmil](/molmil-images/mine/5oy9) | VSV G CR3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Albertini, A.A, Belot, L, Legrand, P, Gaudin, Y. | 登録日 | 2017-09-08 | 公開日 | 2018-03-21 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein. Nat Commun, 9, 2018
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5OYF
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![BU of 5oyf by Molmil](/molmil-images/mine/5oyf) | The crystal structure of CK2alpha in complex with compound 31 | 分子名称: | 2-(1~{H}-benzimidazol-2-yl)-~{N}-[[4-(2-ethylphenyl)-3-methyl-phenyl]methyl]ethanamine, ACETATE ION, Casein kinase II subunit alpha | 著者 | Brear, P, De Fusco, C, Iegre, J, Yoshida, M, Mitchell, S, Rossmann, M, Carro, L, Sore, H, Hyvonen, M, Spring, D. | 登録日 | 2017-09-08 | 公開日 | 2018-02-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Second-generation CK2 alpha inhibitors targeting the alpha D pocket. Chem Sci, 9, 2018
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5OYL
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![BU of 5oyl by Molmil](/molmil-images/mine/5oyl) | VSV G CR2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ... | 著者 | Albertini, A.A, Belot, L, Legrand, P, Gaudin, Y. | 登録日 | 2017-09-11 | 公開日 | 2018-03-21 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein. Nat Commun, 9, 2018
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6RNX
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![BU of 6rnx by Molmil](/molmil-images/mine/6rnx) | Crystal structure of the essential repressor DdrO from radiation-resistant Deinococcus bacteria (Deinococcus deserti) | 分子名称: | CHLORIDE ION, HTH-type transcriptional regulator DdrOC | 著者 | Arnoux, P, Siponen, M.I, Pignol, D, De Groot, A, Blanchard, L. | 登録日 | 2019-05-09 | 公開日 | 2019-10-09 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | Crystal structure of the transcriptional repressor DdrO: insight into the metalloprotease/repressor-controlled radiation response in Deinococcus. Nucleic Acids Res., 47, 2019
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3H73
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5ZX2
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