3GUR

Crystal Structure of mu class glutathione S-transferase (GSTM2-2) in complex with glutathione and 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX)

Summary for 3GUR

• Entry DOI: 10.2210/pdb3gur/pdb
• Related: 3GUS
• Descriptor: Glutathione S-transferase Mu 2, L-gamma-glutamyl-S-{(4R)-4-[(6-hydroxyhexyl)sulfanyl]-7-nitro-4,5-dihydro-2,1,3-benzoxadiazol-4-yl}-L-cysteinylglycine, GLUTATHIONE, ... (5 entities in total)
• Functional Keywords: gstm2-2-inhibitor complex, glutathione-nbdhex covalent complex (sigma-complex), transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P28161
• Total number of polymer chains: 4
• Total formula weight: 104467.85

Authors

Federici, L.,Lo Sterzo, C.,Di Matteo, A.,Scaloni, F.,Federici, G.,Caccuri, A.M. (deposition date: 2009-03-30, release date: 2009-10-27, Last modification date: 2023-11-01)

• Primary citation: Federici, L.,Lo Sterzo, C.,Pezzola, S.,Di Matteo, A.,Scaloni, F.,Federici, G.,Caccuri, A.M.; Structural basis for the binding of the anticancer compound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione s-transferases; Cancer Res., 69:8025-8034, 2009; PubMed: 19808963; DOI: 10.1158/0008-5472.CAN-09-1314

Experimental method

X-RAY DIFFRACTION (2.5 Å)