6BUZ
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![BU of 6buz by Molmil](/molmil-images/mine/6buz) | Cryo-EM structure of CENP-A nucleosome in complex with kinetochore protein CENP-N | 分子名称: | DNA (147-MER), Histone H2A, Histone H2B, ... | 著者 | Chittori, S, Hong, J, Kelly, A.E, Bai, Y, Subramaniam, S. | 登録日 | 2017-12-11 | 公開日 | 2017-12-20 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.92 Å) | 主引用文献 | Structural mechanisms of centromeric nucleosome recognition by the kinetochore protein CENP-N. Science, 359, 2018
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4O88
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![BU of 4o88 by Molmil](/molmil-images/mine/4o88) | Crystal structure of a C-tagged Nuclease | 分子名称: | CHLORIDE ION, N-tagged Nuclease, SULFATE ION | 著者 | Chakravarty, A.K, Smith, P, Shuman, S. | 登録日 | 2013-12-26 | 公開日 | 2014-10-15 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structure, mechanism, and specificity of a eukaryal tRNA restriction enzyme involved in self-nonself discrimination. Cell Rep, 7, 2014
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4O87
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![BU of 4o87 by Molmil](/molmil-images/mine/4o87) | Crystal structure of a N-tagged Nuclease | 分子名称: | CITRIC ACID, N-tagged Nuclease, SULFATE ION | 著者 | Chakravarty, A.K, Smith, P, Shuman, S. | 登録日 | 2013-12-26 | 公開日 | 2014-10-15 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure, mechanism, and specificity of a eukaryal tRNA restriction enzyme involved in self-nonself discrimination. Cell Rep, 7, 2014
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4ONX
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![BU of 4onx by Molmil](/molmil-images/mine/4onx) | 2.8 Angstrom Crystal Structure of Sensor Domain of Histidine Kinase from Clostridium perfringens. | 分子名称: | CHLORIDE ION, SULFATE ION, Sensor histidine kinase, ... | 著者 | Minasov, G, Halavaty, A, Shuvalova, L, Dubrovska, I, Winsor, J, Kwon, K, Shatsman, S, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2014-01-29 | 公開日 | 2014-03-05 | 最終更新日 | 2017-11-22 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | 2.8 Angstrom Crystal Structure of Sensor Domain of Histidine Kinase from Clostridium perfringens. TO BE PUBLISHED
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4NMU
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![BU of 4nmu by Molmil](/molmil-images/mine/4nmu) | Crystal Structure of Thiol-disulfide Oxidoreductase from Bacillus str. 'Ames Ancestor' | 分子名称: | 1,2-ETHANEDIOL, ACETIC ACID, DI(HYDROXYETHYL)ETHER, ... | 著者 | Kim, Y, Zhou, M, Shatsman, S, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2013-11-15 | 公開日 | 2013-12-18 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Crystal Structure of Thiol-disulfide Oxidoreductase from Bacillus str. 'Ames Ancestor' To be Published
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5L4N
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![BU of 5l4n by Molmil](/molmil-images/mine/5l4n) | Leishmania major Pteridine reductase 1 (PTR1) in complex with compound 1 | 分子名称: | (2~{R})-2-(3-hydroxyphenyl)-6-oxidanyl-2,3-dihydrochromen-4-one, 1,2-ETHANEDIOL, ACETATE ION, ... | 著者 | Dello Iacono, L, Di Pisa, F, Pozzi, C, Landi, G, Mangani, S. | 登録日 | 2016-05-26 | 公開日 | 2017-03-22 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity. Molecules, 22, 2017
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6TXA
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![BU of 6txa by Molmil](/molmil-images/mine/6txa) | Crystal structure of tetrameric human D137N-SAMHD1 (residues 109-626) with XTP, dGMPNPP and Mg | 分子名称: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, ... | 著者 | Morris, E.R, Kunzelmann, S, Caswell, S.J, Arnold, L.H, Purkiss, A, Kelly, G, Taylor, I.A. | 登録日 | 2020-01-13 | 公開日 | 2020-06-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.853 Å) | 主引用文献 | Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis. Nat Commun, 11, 2020
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6TXE
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![BU of 6txe by Molmil](/molmil-images/mine/6txe) | Crystal structure of tetrameric human wt-SAMHD1 (residues 109-626) with GTP, dATP, dTMPNPP and Mg | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... | 著者 | Morris, E.R, Kunzelmann, S, Caswell, S.J, Arnold, L.H, Purkiss, A.G, Kelly, G, Taylor, I.A. | 登録日 | 2020-01-14 | 公開日 | 2020-06-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | 主引用文献 | Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis. Nat Commun, 11, 2020
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7SZ7
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![BU of 7sz7 by Molmil](/molmil-images/mine/7sz7) | Cryo-EM structure of the extracellular module of the full-length EGFR bound to TGF-alpha. "tips-juxtaposed" conformation | 分子名称: | Epidermal growth factor receptor, Transforming growth factor alpha | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | 登録日 | 2021-11-25 | 公開日 | 2021-12-15 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
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7SZ1
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![BU of 7sz1 by Molmil](/molmil-images/mine/7sz1) | Cryo-EM structure of the extracellular module of the full-length EGFR L834R bound to EGF. "tips-separated" conformation | 分子名称: | Epidermal growth factor, Epidermal growth factor receptor | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | 登録日 | 2021-11-25 | 公開日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
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7SYD
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![BU of 7syd by Molmil](/molmil-images/mine/7syd) | Cryo-EM structure of the extracellular module of the full-length EGFR bound to EGF "tips-juxtaposed" conformation | 分子名称: | Epidermal growth factor, Epidermal growth factor receptor | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | 登録日 | 2021-11-24 | 公開日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
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7SZ5
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![BU of 7sz5 by Molmil](/molmil-images/mine/7sz5) | Cryo-EM structure of the extracellular module of the full-length EGFR bound to TGF-alpha "tips-separated" conformation | 分子名称: | Epidermal growth factor receptor, Transforming growth factor alpha | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | 登録日 | 2021-11-25 | 公開日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
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7SYE
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![BU of 7sye by Molmil](/molmil-images/mine/7sye) | Cryo-EM structure of the extracellular module of the full-length EGFR bound to EGF. "tips-separated" conformation | 分子名称: | Epidermal growth factor, Epidermal growth factor receptor | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | 登録日 | 2021-11-24 | 公開日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
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7SZ0
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![BU of 7sz0 by Molmil](/molmil-images/mine/7sz0) | Cryo-EM structure of the extracellular module of the full-length EGFR L834R bound to EGF. "tips-juxtaposed" conformation | 分子名称: | Epidermal growth factor, Epidermal growth factor receptor | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | 登録日 | 2021-11-25 | 公開日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
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5LHR
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![BU of 5lhr by Molmil](/molmil-images/mine/5lhr) | The catalytic domain of murine urokinase-type plasminogen activator in complex with the active site binding inhibitory nanobody Nb22 | 分子名称: | Camelid-Derived Antibody Fragment Nb22, Urokinase-type plasminogen activator | 著者 | Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A. | 登録日 | 2016-07-12 | 公開日 | 2017-06-28 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator. Sci Rep, 7, 2017
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8DI5
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![BU of 8di5 by Molmil](/molmil-images/mine/8di5) | Cryo-EM structure of SARS-CoV-2 Beta (B.1.351) spike protein in complex with VH domain F6 (focused refinement of RBD and VH F6) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, VH F6 | 著者 | Zhu, X, Saville, J.W, Mannar, D, Berezuk, A.M, Subramaniam, S. | 登録日 | 2022-06-28 | 公開日 | 2022-08-24 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | Potent and broad neutralization of SARS-CoV-2 variants of concern (VOCs) including omicron sub-lineages BA.1 and BA.2 by biparatopic human VH domains. Iscience, 25, 2022
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7T8O
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![BU of 7t8o by Molmil](/molmil-images/mine/7t8o) | Crystal Structure of the Crp/Fnr Family Transcriptional Regulator from Listeria monocytogenes | 分子名称: | Lmo0753 protein, SULFATE ION | 著者 | Kim, Y, Makowska-Grzyska, M, Maltseva, N, Shatsman, S, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2021-12-16 | 公開日 | 2021-12-29 | 最終更新日 | 2023-04-19 | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | 主引用文献 | Crystal Structure of the Crp/Fnr Family Transcriptional Regulator from Listeria monocytogenes To Be Published
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5LQD
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![BU of 5lqd by Molmil](/molmil-images/mine/5lqd) | Trehalose-6-phosphate synthase, GDP-glucose-dependent OtsA | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Alpha,alpha-trehalose-phosphate synthase | 著者 | Miah, F, Asencion Diez, M.D, Stevenson, C.E.M, Lawson, D.M, Iglesias, A.A, Bornemann, S. | 登録日 | 2016-08-16 | 公開日 | 2016-12-07 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | The Production and Utilization of GDP-glucose in the Biosynthesis of Trehalose 6-Phosphate by Streptomyces venezuelae. J. Biol. Chem., 292, 2017
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5LHP
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![BU of 5lhp by Molmil](/molmil-images/mine/5lhp) | The p-aminobenzamidine active site inhibited catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7 | 分子名称: | 1,2-ETHANEDIOL, Camelid-Derived Antibody Fragment, P-AMINO BENZAMIDINE, ... | 著者 | Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A. | 登録日 | 2016-07-12 | 公開日 | 2017-06-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | 主引用文献 | Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator. Sci Rep, 7, 2017
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5LHN
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![BU of 5lhn by Molmil](/molmil-images/mine/5lhn) | The catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7 | 分子名称: | 1,2-ETHANEDIOL, Camelid-Derived Antibody Fragment Nb7, SULFATE ION, ... | 著者 | Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P, Andreasen, P.A. | 登録日 | 2016-07-12 | 公開日 | 2017-06-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator. Sci Rep, 7, 2017
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8DCD
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![BU of 8dcd by Molmil](/molmil-images/mine/8dcd) | RNA ligase RtcB from Pyrococcus horikoshii in complex with Zn2+ and GTP | 分子名称: | CHLORIDE ION, GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Jacewicz, A, Dantuluri, S, Shuman, S. | 登録日 | 2022-06-16 | 公開日 | 2022-10-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Structures of RNA ligase RtcB in complexes with divalent cations and GTP. Rna, 28, 2022
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8DC9
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![BU of 8dc9 by Molmil](/molmil-images/mine/8dc9) | RNA ligase RtcB from Pyrococcus horikoshii in complex with Mn2+ and GTP | 分子名称: | CHLORIDE ION, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... | 著者 | Jacewicz, A, Dantuluri, S, Shuman, S. | 登録日 | 2022-06-16 | 公開日 | 2022-10-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | Structures of RNA ligase RtcB in complexes with divalent cations and GTP. Rna, 28, 2022
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8DCG
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![BU of 8dcg by Molmil](/molmil-images/mine/8dcg) | Structure of guanylylated RNA ligase RtcB from Pyrococcus horikoshii | 分子名称: | CHLORIDE ION, GUANOSINE-5'-MONOPHOSPHATE, SULFATE ION, ... | 著者 | Jacewicz, A, Dantuluri, S, Shuman, S. | 登録日 | 2022-06-16 | 公開日 | 2022-10-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structures of RNA ligase RtcB in complexes with divalent cations and GTP. Rna, 28, 2022
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5LHQ
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![BU of 5lhq by Molmil](/molmil-images/mine/5lhq) | The EGR-cmk active site inhibited catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7 | 分子名称: | 1,2-ETHANEDIOL, Camelid-Derived Antibody Fragment Nb7, L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide, ... | 著者 | Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A. | 登録日 | 2016-07-12 | 公開日 | 2017-06-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator. Sci Rep, 7, 2017
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8DCB
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![BU of 8dcb by Molmil](/molmil-images/mine/8dcb) | RNA ligase RtcB from Pyrococcus horikoshii in complex with Ni2+ and GTP | 分子名称: | CHLORIDE ION, GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Jacewicz, A, Dantuluri, S, Shuman, S. | 登録日 | 2022-06-16 | 公開日 | 2022-10-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structures of RNA ligase RtcB in complexes with divalent cations and GTP. Rna, 28, 2022
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