7WLJ
| CryoEM structure of human low-voltage activated T-type calcium channel Cav3.3 in complex with mibefradil (MIB) | 分子名称: | (1S,2S)-2-(2-{[3-(1H-benzimidazol-2-yl)propyl](methyl)amino}ethyl)-6-fluoro-1-(propan-2-yl)-1,2,3,4-tetrahydronaphthalen-2-yl methoxyacetate, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | He, L, Yu, Z, Dong, Y, Chen, Q, Zhao, Y. | 登録日 | 2022-01-13 | 公開日 | 2022-05-04 | 最終更新日 | 2022-05-25 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structure, gating, and pharmacology of human Ca V 3.3 channel. Nat Commun, 13, 2022
|
|
7WLL
| CryoEM structure of human low-voltage activated T-type calcium channel Cav3.3 in complex with pimozide(PMZ) | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1~{H}-benzimidazol-2-one, ... | 著者 | He, L, Yu, Z, Dong, Y, Chen, Q, Zhao, Y. | 登録日 | 2022-01-13 | 公開日 | 2022-05-04 | 最終更新日 | 2022-05-25 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure, gating, and pharmacology of human Ca V 3.3 channel. Nat Commun, 13, 2022
|
|
7DL2
| Cryo-EM structure of human TSC complex | 分子名称: | Hamartin, Isoform 7 of Tuberin, TBC1 domain family member 7, ... | 著者 | Yang, H, Yu, Z, Chen, X, Li, J, Li, N, Cheng, J, Gao, N, Yuan, H, Ye, D, Guan, K, Xu, Y. | 登録日 | 2020-11-25 | 公開日 | 2020-12-16 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Structural insights into TSC complex assembly and GAP activity on Rheb. Nat Commun, 12, 2021
|
|
7DN3
| Structure of Human RNA Polymerase III elongation complex | 分子名称: | DNA (5'-D(P*TP*CP*GP*TP*CP*TP*GP*AP*TP*CP*TP*CP*GP*GP*AP*A)-3'), DNA (5'-D(P*TP*TP*CP*CP*GP*AP*GP*AP*TP*CP*AP*GP*AP*CP*GP*AP*GP*AP*TP*CP*GP*GP*G)-3'), DNA-directed RNA polymerase III subunit RPC1, ... | 著者 | Li, L, Yu, Z, Zhao, D, Ren, Y, Hou, H, Xu, Y. | 登録日 | 2020-12-08 | 公開日 | 2021-03-17 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure of human RNA polymerase III elongation complex. Cell Res., 31, 2021
|
|
7DU2
| RNA polymerase III EC complex in post-translocation state | 分子名称: | DNA (5'-D(P*GP*TP*CP*TP*GP*AP*TP*CP*TP*CP*GP*GP*AP*A)-3'), DNA (5'-D(P*TP*TP*CP*CP*GP*AP*GP*AP*TP*CP*AP*GP*AP*CP*GP*AP*GP*AP*T)-3'), DNA-directed RNA polymerase III subunit RPC1, ... | 著者 | Li, L, Yu, Z, Zhao, D, Ren, Y, Hou, H, Xu, Y. | 登録日 | 2021-01-07 | 公開日 | 2021-03-17 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | 主引用文献 | Structure of human RNA polymerase III elongation complex. Cell Res., 31, 2021
|
|
7US2
| PARL-cleaved Skd3 (human ClpB) E455Q Nucleotide Binding Domain hexamer bound to ATPgammaS, open conformation | 分子名称: | Caseinolytic peptidase B protein homolog, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | 著者 | Gupta, A, Lentzsch, A.M, Siegel, A.S, Yu, Z, Lu, C, Chio, U.S, Cheng, Y, Shan, S.-o. | 登録日 | 2022-04-22 | 公開日 | 2023-04-26 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | 主引用文献 | Dodecamer assembly of a metazoan AAA + chaperone couples substrate extraction to refolding. Sci Adv, 9, 2023
|
|
8JHL
| GDP-bound KRAS G12D in complex with YK-8S | 分子名称: | 1-[4-[7-(8-ethynyl-7-fluoranyl-naphthalen-1-yl)-8-fluoranyl-2-[[(2~{R},8~{S})-2-fluoranyl-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methoxy]pyrido[4,3-d]pyrimidin-4-yl]piperazin-1-yl]-3-oxidanyl-propan-1-one, GTPase KRas, N-terminally processed, ... | 著者 | Zhang, Z.M, Wang, R.L. | 登録日 | 2023-05-23 | 公開日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.10004044 Å) | 主引用文献 | Simultaneous Covalent Modification of K-Ras(G12D) and K-Ras(G12C) with Tunable Oxirane Electrophiles. J.Am.Chem.Soc., 145, 2023
|
|
8JGD
| GDP-bound KRAS G12C in complex with YK-8S | 分子名称: | (2~{S})-1-[4-[7-(8-ethynyl-7-fluoranyl-naphthalen-1-yl)-8-fluoranyl-2-[[(2~{R},8~{S})-2-fluoranyl-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methoxy]pyrido[4,3-d]pyrimidin-4-yl]piperazin-1-yl]-2-oxidanyl-propan-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Zhang, Z.M, Wang, R.L. | 登録日 | 2023-05-20 | 公開日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.60037053 Å) | 主引用文献 | Simultaneous Covalent Modification of K-Ras(G12D) and K-Ras(G12C) with Tunable Oxirane Electrophiles. J.Am.Chem.Soc., 145, 2023
|
|
5XEP
| Crystal structure of BRP39, a chitinase-like protein, at 2.6 Angstorm resolution | 分子名称: | 1,2-ETHANEDIOL, Chitinase-3-like protein 1 | 著者 | Mohanty, A.K, Fisher, A.J, Choudhary, S, Kaushik, J.K. | 登録日 | 2017-04-05 | 公開日 | 2018-04-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal Structure of BRP39, a signalling glycoprotein expressed during mammary gland apoptosis. To be published
|
|
6DV6
| Structure of the Salmonella SPI-1 type III secretion injectisome secretin InvG (residues 176-end) in the open gate state | 分子名称: | Protein InvG | 著者 | Hu, J, Worrall, L.J, Vuckovic, M, Atkinson, C.E, Strynadka, N.C.J. | 登録日 | 2018-06-22 | 公開日 | 2018-10-03 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Cryo-EM analysis of the T3S injectisome reveals the structure of the needle and open secretin. Nat Commun, 9, 2018
|
|
6DUZ
| Structure of the periplasmic domains of PrgH and PrgK from the assembled Salmonella type III secretion injectisome needle complex | 分子名称: | Lipoprotein PrgK, Protein PrgH | 著者 | Hu, J, Worrall, L.J, Vuckovic, M, Atkinson, C.E, Strynadka, N.C.J. | 登録日 | 2018-06-22 | 公開日 | 2018-10-03 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Cryo-EM analysis of the T3S injectisome reveals the structure of the needle and open secretin. Nat Commun, 9, 2018
|
|
5XDZ
| Crystal structure of zebrafish SNX25 PX domain | 分子名称: | CHLORIDE ION, Cellular trafficking protein, SODIUM ION | 著者 | Su, K, Zhang, Y, Xu, J, Liu, J. | 登録日 | 2017-03-30 | 公開日 | 2017-06-14 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure of the PX domain of SNX25 reveals a novel phospholipid recognition model by dimerization in the PX domain FEBS Lett., 591, 2017
|
|
6X2Z
| hEAAT3-OFS-Asp | 分子名称: | ASPARTIC ACID, Excitatory amino acid transporter 3, SODIUM ION | 著者 | Qiu, B, Matthies, D, Boudker, O. | 登録日 | 2020-05-21 | 公開日 | 2021-03-17 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | 主引用文献 | Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport. Sci Adv, 7, 2021
|
|
6X3E
| hEAAT3-Asymmetric-1o2i | 分子名称: | ASPARTIC ACID, Excitatory amino acid transporter 3, SODIUM ION | 著者 | Qiu, B, Matthies, D, Boudker, O. | 登録日 | 2020-05-21 | 公開日 | 2021-03-17 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | 主引用文献 | Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport. Sci Adv, 7, 2021
|
|
6X3F
| hEAAT3-IFS-Apo | 分子名称: | CHOLINE ION, Excitatory amino acid transporter 3 | 著者 | Qiu, B, Matthies, D, Boudker, O. | 登録日 | 2020-05-21 | 公開日 | 2021-03-17 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | 主引用文献 | Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport. Sci Adv, 7, 2021
|
|
6X2L
| hEAAT3-IFS-Na | 分子名称: | Excitatory amino acid transporter 3 | 著者 | Qiu, B, Matthies, D, Boudker, O. | 登録日 | 2020-05-20 | 公開日 | 2021-03-17 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport. Sci Adv, 7, 2021
|
|
6X45
| |
6XFU
| |
6XG6
| Full-length human mitochondrial Hsp90 (TRAP1) with ADP-BeF3 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Heat shock protein 75 kDa, ... | 著者 | Liu, Y.X, Wang, F, Agard, D.A. | 登録日 | 2020-06-17 | 公開日 | 2020-09-30 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | General and robust covalently linked graphene oxide affinity grids for high-resolution cryo-EM. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
5GSA
| EED in complex with an allosteric PRC2 inhibitor | 分子名称: | Histone-lysine N-methyltransferase EZH2, N-(furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, Polycomb protein EED | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H. | 登録日 | 2016-08-15 | 公開日 | 2017-02-01 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of Nat. Chem. Biol., 13, 2017
|
|
8VF6
| Crystal structure of Serine/threonine-protein kinase 33 (STK33) Kinase Domain in complex with inhibitor CDD-2211 | 分子名称: | Serine/threonine-protein kinase 33, {3-[([1,1'-biphenyl]-2-yl)ethynyl]-1H-indazol-5-yl}[(3R)-3-(dimethylamino)pyrrolidin-1-yl]methanone | 著者 | Ta, H.M, Kim, C, Ku, K.A, Matzuk, M.M. | 登録日 | 2023-12-21 | 公開日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Reversible male contraception by targeted inhibition of serine/threonine kinase 33. Science, 384, 2024
|
|
7QK4
| EED in complex with PRC2 allosteric inhibitor compound 22 (MAK683) | 分子名称: | CHLORIDE ION, Histone-lysine N-methyltransferase EZH2, N-[(5-fluoranyl-2,3-dihydro-1-benzofuran-4-yl)methyl]-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H, Scheufler, C. | 登録日 | 2021-12-17 | 公開日 | 2022-04-13 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.602 Å) | 主引用文献 | Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies. J.Med.Chem., 65, 2022
|
|
7QJG
| EED in complex with PRC2 allosteric inhibitor compound 6 | 分子名称: | CHLORIDE ION, Histone-lysine N-methyltransferase EZH2, N-(2,3-dihydro-1-benzofuran-7-ylmethyl)-8-[4-[(dimethylamino)methyl]phenyl]-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H, Scheufler, C. | 登録日 | 2021-12-16 | 公開日 | 2022-04-13 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies. J.Med.Chem., 65, 2022
|
|
7QJU
| EED in complex with PRC2 allosteric inhibitor compound 7 | 分子名称: | CHLORIDE ION, Histone-lysine N-methyltransferase EZH2, N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-[4-[(dimethylamino)methyl]phenyl]-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H, Scheufler, C. | 登録日 | 2021-12-17 | 公開日 | 2022-04-13 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies. J.Med.Chem., 65, 2022
|
|
8J6T
| Cryo-EM structure of the double CAF-1 bound right-handed Di-tetrasome | 分子名称: | Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, Histone H3.1, ... | 著者 | Liu, C.P, Yu, Z.Y, Xu, R.M. | 登録日 | 2023-04-26 | 公開日 | 2023-08-16 | 最終更新日 | 2023-09-06 | 実験手法 | ELECTRON MICROSCOPY (6.6 Å) | 主引用文献 | Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science, 381, 2023
|
|