6NJO
 
 | | Structure of the assembled ATPase EscN from the enteropathogenic E. coli (EPEC) type III secretion system | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | | 著者 | Majewski, D.D, Worrall, L.J, Hong, C, Atkinson, C.E, Vuckovic, M, Watanabe, N, Yu, Z, Strynadka, N.C.J. | | 登録日 | 2019-01-03 | | 公開日 | 2019-02-20 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | | 主引用文献 | Cryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry.
Nat Commun, 10, 2019
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8HLP
 | | Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 (apo) | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Wei, Y, Yu, Z, Zhao, Y. | | 登録日 | 2022-11-30 | | 公開日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural bases of inhibitory mechanism of Ca V 1.2 channel inhibitors.
Nat Commun, 15, 2024
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8HMB
 | | Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 in complex with benidipine (BEN) | | 分子名称: | (3R)-1-benzylpiperidin-3-yl methyl (2R,3R,4R,5R,6S)-2,6-dimethyl-4-(3-nitrophenyl)piperidine-3,5-dicarboxylate, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Wei, Y, Yu, Z, Zhao, Y. | | 登録日 | 2022-12-02 | | 公開日 | 2024-04-24 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural bases of inhibitory mechanism of Ca V 1.2 channel inhibitors.
Nat Commun, 15, 2024
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8HMA
 | | Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 in complex with tetrandrine (TET) | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 6,6',7,12-tetramethoxy-2,2'-dimethyl-1beta-3,4-didehydroberbaman, ... | | 著者 | Wei, Y, Yu, Z, Zhao, Y. | | 登録日 | 2022-12-02 | | 公開日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural bases of inhibitory mechanism of Ca V 1.2 channel inhibitors.
Nat Commun, 15, 2024
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7E9F
 | | Cryo-EM structure of the 2:1 Orc1 BAH domain in complex with nucleosome | | 分子名称: | DNA (147-mer), Histone H2A.2, Histone H2B.2, ... | | 著者 | Jiang, H, Yu, C, Liu, C.P, Han, X, Yu, Z, Xu, R.M. | | 登録日 | 2021-03-04 | | 公開日 | 2022-09-07 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Nucleosome binding relinquishes the association of the BAH domain of Orc1 with Sir1
To Be Published
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7E9C
 | | Cryo-EM structure of the 1:1 Orc1 BAH domain in complex with nucleosome | | 分子名称: | DNA (147-mer), Histone H2A.2, Histone H2B.2, ... | | 著者 | Jiang, H, Yu, C, Liu, C.P, Han, X, Yu, Z, Xu, R.M. | | 登録日 | 2021-03-04 | | 公開日 | 2022-09-07 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Nucleosome binding relinquishes the association of the BAH domain of Orc1 with Sir1
To Be Published
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5WC3
 | | SpoIIIAG | | 分子名称: | SpoIIIAG, Stage III sporulation engulfment assemblyprotein | | 著者 | Zeytuni, N, Hong, C, Worrall, L.J, Huang, R.K, Yu, Z, Strynadka, N.C.J. | | 登録日 | 2017-06-29 | | 公開日 | 2017-08-16 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Near-atomic resolution cryoelectron microscopy structure of the 30-fold homooligomeric SpoIIIAG channel essential to spore formation in Bacillus subtilis.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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7WLI
 | | CryoEM structure of human low-voltage activated T-type calcium channel CaV3.3 (apo) | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | He, L, Yu, Z, Dong, Y, Chen, Q, Zhao, Y. | | 登録日 | 2022-01-13 | | 公開日 | 2022-05-04 | | 最終更新日 | 2022-05-25 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure, gating, and pharmacology of human Ca V 3.3 channel.
Nat Commun, 13, 2022
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7WLK
 | | CryoEM structure of human low-voltage activated T-type calcium channel Cav3.3 in complex with Otilonium Bromide(OB) | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-[diethyl(methyl)-$l^{4}-azanyl]ethyl 4-[(2-octoxyphenyl)carbonylamino]benzoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | He, L, Yu, Z, Dong, Y, Chen, Q, Zhao, Y. | | 登録日 | 2022-01-13 | | 公開日 | 2022-05-04 | | 最終更新日 | 2022-05-25 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structure, gating, and pharmacology of human Ca V 3.3 channel.
Nat Commun, 13, 2022
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7WLL
 | | CryoEM structure of human low-voltage activated T-type calcium channel Cav3.3 in complex with pimozide(PMZ) | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1~{H}-benzimidazol-2-one, ... | | 著者 | He, L, Yu, Z, Dong, Y, Chen, Q, Zhao, Y. | | 登録日 | 2022-01-13 | | 公開日 | 2022-05-04 | | 最終更新日 | 2022-05-25 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structure, gating, and pharmacology of human Ca V 3.3 channel.
Nat Commun, 13, 2022
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7WLJ
 | | CryoEM structure of human low-voltage activated T-type calcium channel Cav3.3 in complex with mibefradil (MIB) | | 分子名称: | (1S,2S)-2-(2-{[3-(1H-benzimidazol-2-yl)propyl](methyl)amino}ethyl)-6-fluoro-1-(propan-2-yl)-1,2,3,4-tetrahydronaphthalen-2-yl methoxyacetate, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | He, L, Yu, Z, Dong, Y, Chen, Q, Zhao, Y. | | 登録日 | 2022-01-13 | | 公開日 | 2022-05-04 | | 最終更新日 | 2022-05-25 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structure, gating, and pharmacology of human Ca V 3.3 channel.
Nat Commun, 13, 2022
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7DL2
 | | Cryo-EM structure of human TSC complex | | 分子名称: | Hamartin, Isoform 7 of Tuberin, TBC1 domain family member 7, ... | | 著者 | Yang, H, Yu, Z, Chen, X, Li, J, Li, N, Cheng, J, Gao, N, Yuan, H, Ye, D, Guan, K, Xu, Y. | | 登録日 | 2020-11-25 | | 公開日 | 2020-12-16 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Structural insights into TSC complex assembly and GAP activity on Rheb.
Nat Commun, 12, 2021
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7DU2
 | | RNA polymerase III EC complex in post-translocation state | | 分子名称: | DNA (5'-D(P*GP*TP*CP*TP*GP*AP*TP*CP*TP*CP*GP*GP*AP*A)-3'), DNA (5'-D(P*TP*TP*CP*CP*GP*AP*GP*AP*TP*CP*AP*GP*AP*CP*GP*AP*GP*AP*T)-3'), DNA-directed RNA polymerase III subunit RPC1, ... | | 著者 | Li, L, Yu, Z, Zhao, D, Ren, Y, Hou, H, Xu, Y. | | 登録日 | 2021-01-07 | | 公開日 | 2021-03-17 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | | 主引用文献 | Structure of human RNA polymerase III elongation complex.
Cell Res., 31, 2021
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7DN3
 | | Structure of Human RNA Polymerase III elongation complex | | 分子名称: | DNA (5'-D(P*TP*CP*GP*TP*CP*TP*GP*AP*TP*CP*TP*CP*GP*GP*AP*A)-3'), DNA (5'-D(P*TP*TP*CP*CP*GP*AP*GP*AP*TP*CP*AP*GP*AP*CP*GP*AP*GP*AP*TP*CP*GP*GP*G)-3'), DNA-directed RNA polymerase III subunit RPC1, ... | | 著者 | Li, L, Yu, Z, Zhao, D, Ren, Y, Hou, H, Xu, Y. | | 登録日 | 2020-12-08 | | 公開日 | 2021-03-17 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structure of human RNA polymerase III elongation complex.
Cell Res., 31, 2021
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8JGD
 | | GDP-bound KRAS G12C in complex with YK-8S | | 分子名称: | (2~{S})-1-[4-[7-(8-ethynyl-7-fluoranyl-naphthalen-1-yl)-8-fluoranyl-2-[[(2~{R},8~{S})-2-fluoranyl-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methoxy]pyrido[4,3-d]pyrimidin-4-yl]piperazin-1-yl]-2-oxidanyl-propan-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Zhang, Z.M, Wang, R.L. | | 登録日 | 2023-05-20 | | 公開日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.60037053 Å) | | 主引用文献 | Simultaneous Covalent Modification of K-Ras(G12D) and K-Ras(G12C) with Tunable Oxirane Electrophiles.
J.Am.Chem.Soc., 145, 2023
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8JHL
 | | GDP-bound KRAS G12D in complex with YK-8S | | 分子名称: | 1-[4-[7-(8-ethynyl-7-fluoranyl-naphthalen-1-yl)-8-fluoranyl-2-[[(2~{R},8~{S})-2-fluoranyl-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methoxy]pyrido[4,3-d]pyrimidin-4-yl]piperazin-1-yl]-3-oxidanyl-propan-1-one, GTPase KRas, N-terminally processed, ... | | 著者 | Zhang, Z.M, Wang, R.L. | | 登録日 | 2023-05-23 | | 公開日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.10004044 Å) | | 主引用文献 | Simultaneous Covalent Modification of K-Ras(G12D) and K-Ras(G12C) with Tunable Oxirane Electrophiles.
J.Am.Chem.Soc., 145, 2023
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5GSA
 | | EED in complex with an allosteric PRC2 inhibitor | | 分子名称: | Histone-lysine N-methyltransferase EZH2, N-(furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, Polycomb protein EED | | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H. | | 登録日 | 2016-08-15 | | 公開日 | 2017-02-01 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of
Nat. Chem. Biol., 13, 2017
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7QK4
 | | EED in complex with PRC2 allosteric inhibitor compound 22 (MAK683) | | 分子名称: | CHLORIDE ION, Histone-lysine N-methyltransferase EZH2, N-[(5-fluoranyl-2,3-dihydro-1-benzofuran-4-yl)methyl]-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... | | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H, Scheufler, C. | | 登録日 | 2021-12-17 | | 公開日 | 2022-04-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.602 Å) | | 主引用文献 | Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
J.Med.Chem., 65, 2022
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7QJU
 | | EED in complex with PRC2 allosteric inhibitor compound 7 | | 分子名称: | CHLORIDE ION, Histone-lysine N-methyltransferase EZH2, N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-[4-[(dimethylamino)methyl]phenyl]-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... | | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H, Scheufler, C. | | 登録日 | 2021-12-17 | | 公開日 | 2022-04-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
J.Med.Chem., 65, 2022
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7QJG
 | | EED in complex with PRC2 allosteric inhibitor compound 6 | | 分子名称: | CHLORIDE ION, Histone-lysine N-methyltransferase EZH2, N-(2,3-dihydro-1-benzofuran-7-ylmethyl)-8-[4-[(dimethylamino)methyl]phenyl]-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... | | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H, Scheufler, C. | | 登録日 | 2021-12-16 | | 公開日 | 2022-04-13 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
J.Med.Chem., 65, 2022
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6Q15
 | | Structure of the Salmonella SPI-1 injectisome needle complex | | 分子名称: | Lipoprotein PrgK, Protein InvG, Protein PrgH, ... | | 著者 | Hu, J, Worrall, L.J, Strynadka, N.C.J. | | 登録日 | 2019-08-02 | | 公開日 | 2019-10-23 | | 最終更新日 | 2020-01-08 | | 実験手法 | ELECTRON MICROSCOPY (5.15 Å) | | 主引用文献 | T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly.
Nat Microbiol, 4, 2019
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6Q14
 | | Structure of the Salmonella SPI-1 injectisome NC-base | | 分子名称: | Lipoprotein PrgK, Protein InvG, Protein PrgH, ... | | 著者 | Hu, J, Worrall, L.J, Strynadka, N.C.J. | | 登録日 | 2019-08-02 | | 公開日 | 2019-10-23 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly.
Nat Microbiol, 4, 2019
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6QDB
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6QDA
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6QDG
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