9EUP
| Inhibitor-free outward-open structure of Drosophila dopamine transporter | 分子名称: | 9D5 ANTIBODY, HEAVY CHAIN, LIGHT CHAIN, ... | 著者 | Pedersen, C.N, Yang, F, Ita, S, Xu, Y, Akunuri, R, Trampari, S, Neumann, C.M.T, Desdorf, L.M, Schioett, B, Salvino, J.M, Mortensen, O.V, Nissen, P, Shahsavar, A. | 登録日 | 2024-03-27 | 公開日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Cryo-EM structure of the dopamine transporter with a novel atypical non-competitive inhibitor bound to the orthosteric site. J.Neurochem., 2024
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9EUO
| Outward-open structure of Drosophila dopamine transporter bound to an atypical non-competitive inhibitor | 分子名称: | 9D5 ANTIBODY, HEAVY CHAIN, LIGHT CHAIN, ... | 著者 | Pedersen, C.N, Yang, F, Ita, S, Xu, Y, Akunuri, R, Trampari, S, Neumann, C.M.T, Desdorf, L.M, Schioett, B, Salvino, J.M, Mortensen, O.V, Nissen, P, Shahsavar, A. | 登録日 | 2024-03-27 | 公開日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM structure of the dopamine transporter with a novel atypical non-competitive inhibitor bound to the orthosteric site. J.Neurochem., 2024
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7BZ2
| Cryo-EM structure of the formoterol-bound beta2 adrenergic receptor-Gs protein complex. | 分子名称: | Beta2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhang, Y.N, Yang, F, Ling, S.L, Lv, P, Zhou, Y.X, Fang, W, Sun, W, Shi, P, Tian, C.L. | 登録日 | 2020-04-26 | 公開日 | 2020-08-05 | 実験手法 | ELECTRON MICROSCOPY (3.82 Å) | 主引用文献 | Single-particle cryo-EM structural studies of the beta2AR-Gs complex bound with a full agonist formoterol. Cell Discov, 6, 2020
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8ZBE
| cryo-EM structure of the octreotide-bound SSTR5-Gi complex | 分子名称: | Beta-2 adrenergic receptor,Somatostatin receptor type 5,lgbit (fusion protein), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Li, Y.G, Meng, X.Y, Yang, X.R, Ling, S.L, Shi, P, Tian, C.L, Yang, F. | 登録日 | 2024-04-26 | 公開日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | Structural insights into somatostatin receptor 5 bound with cyclic peptides. Acta Pharmacol.Sin., 2024
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8ZCJ
| Cryo-EM structure of the pasireotide-bound SSTR5-Gi complex | 分子名称: | 004-DTR-LYS-TYR-PHA-HYP, Beta-2 adrenergic receptor,Somatostatin receptor type 5,lgbit (fusion protein), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Li, Y.G, Meng, X.Y, Yang, X.R, Ling, S.L, Shi, P, Tian, C.L, Yang, F. | 登録日 | 2024-04-29 | 公開日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Structural insights into somatostatin receptor 5 bound with cyclic peptides. Acta Pharmacol.Sin., 2024
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1JFH
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3H94
| Crystal structure of the membrane fusion protein CusB from Escherichia coli | 分子名称: | Cation efflux system protein cusB, SILVER ION | 著者 | Su, C.-C, Yang, F, Long, F, Reyon, D, Routh, M.D, Kuo, D.W, Mokhtari, A.K, Van Ornam, J.D, Rabe, K.L, Hoy, J.A, Lee, Y.J, Rajashankar, K.R, Yu, E.W. | 登録日 | 2009-04-30 | 公開日 | 2009-08-18 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3.84 Å) | 主引用文献 | Crystal structure of the membrane fusion protein CusB from Escherichia coli J.Mol.Biol., 393, 2009
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3HGG
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3BCG
| Conformational changes of the AcrR regulator reveal a mechanism of induction | 分子名称: | HTH-type transcriptional regulator acrR | 著者 | Gu, R, Li, M, Su, C.C, Long, F, Yang, F, McDermott, G, Yu, E.Y. | 登録日 | 2007-11-12 | 公開日 | 2008-02-26 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Conformational change of the AcrR regulator reveals a possible mechanism of induction. Acta Crystallogr.,Sect.F, 64, 2008
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3OOC
| Crystal structure of the membrane fusion protein CusB from Escherichia coli | 分子名称: | Cation efflux system protein cusB | 著者 | Su, C.-C, Yang, F, Long, F, Reyon, D, Routh, M.D, Kuo, D.W, Mokhtari, A.K, Van Ornam, J.D, Rabe, K.L, Hoy, J.A, Lee, Y.J, Rajashankar, K.R, Yu, E.W. | 登録日 | 2010-08-30 | 公開日 | 2010-12-29 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3.404 Å) | 主引用文献 | Crystal structure of the membrane fusion protein CusB from Escherichia coli. J.Mol.Biol., 393, 2009
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1OSE
| Porcine pancreatic alpha-amylase complexed with acarbose | 分子名称: | 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... | 著者 | Gilles, C, Payan, F. | 登録日 | 1996-03-20 | 公開日 | 1997-04-01 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of pig pancreatic alpha-amylase isoenzyme II, in complex with the carbohydrate inhibitor acarbose. Eur.J.Biochem., 238, 1996
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3B9M
| Human serum albumin complexed with myristate, 3'-azido-3'-deoxythymidine (AZT) and salicylic acid | 分子名称: | 2-HYDROXYBENZOIC ACID, 3'-azido-3'-deoxythymidine, MYRISTIC ACID, ... | 著者 | Zhu, L, Yang, F, Chen, L, Meehan, E.J, Huang, M. | 登録日 | 2007-11-05 | 公開日 | 2008-05-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | A new drug binding subsite on human serum albumin and drug-drug interaction studied by X-ray crystallography J.Struct.Biol., 162, 2008
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3B9L
| Human serum albumin complexed with myristate and AZT | 分子名称: | 3'-azido-3'-deoxythymidine, MYRISTIC ACID, Serum albumin | 著者 | Zhu, L, Yang, F, Chen, L, Meehan, E.J, Huang, M. | 登録日 | 2007-11-05 | 公開日 | 2008-05-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | A new drug binding subsite on human serum albumin and drug-drug interaction studied by X-ray crystallography J.Struct.Biol., 162, 2008
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1HX0
| Structure of pig pancreatic alpha-amylase complexed with the "truncate" acarbose molecule (pseudotrisaccharide) | 分子名称: | 1,2-ETHANEDIOL, 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ALPHA AMYLASE (PPA), ... | 著者 | Qian, M, Payan, F. | 登録日 | 2001-01-11 | 公開日 | 2001-08-08 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Enzyme-catalyzed condensation reaction in a mammalian alpha-amylase. High-resolution structural analysis of an enzyme-inhibitor complex Biochemistry, 40, 2001
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1NDG
| Crystal structure of Fab fragment of antibody HyHEL-8 complexed with its antigen lysozyme | 分子名称: | ACETIC ACID, Lysozyme C, antibody kappa light chain, ... | 著者 | Mariuzza, R.A, Li, Y, Li, H, Yang, F, Smith-Gill, S.J. | 登録日 | 2002-12-09 | 公開日 | 2003-06-03 | 最終更新日 | 2021-10-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | X-ray snapshots of the maturation of an antibody response to a protein antigen Nat.Struct.Biol., 10, 2003
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3HGY
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4AUA
| Liganded X-ray crystal structure of cyclin dependent kinase 6 (CDK6) | 分子名称: | 1H-benzimidazol-2-yl(1H-pyrrol-2-yl)methanone, CYCLIN-DEPENDENT KINASE 6 | 著者 | Cho, Y.S, Angove, H, Brain, C, Chen, C.H.T, Cheng, R, Chopra, R, Chung, K, Congreve, M, Dagostin, C, Davis, D, Feltell, R, Giraldes, J, Hiscock, S, Kim, S, Kovats, S, Lagu, B, Lewry, K, Loo, A, Lu, Y, Luzzio, M, Maniara, W, Mcmenamin, R, Mortenson, P, Benning, R, O'Reilly, M, Rees, D, Shen, J, Smith, T, Wang, Y, Williams, G, Woolford, A, Wrona, W, Xu, M, Yang, F, Howard, S. | 登録日 | 2012-05-15 | 公開日 | 2013-02-06 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors. ACS Med Chem Lett, 3, 2012
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3CX9
| Crystal Structure of Human serum albumin complexed with Myristic acid and lysophosphatidylethanolamine | 分子名称: | (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, MYRISTIC ACID, Serum albumin | 著者 | Guo, S, Yang, F, Chen, L, Bian, C, Huang, M. | 登録日 | 2008-04-24 | 公開日 | 2009-04-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis of transport of lysophospholipids by human serum albumin. Biochem.J., 423, 2009
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1KXV
| Camelid VHH Domains in Complex with Porcine Pancreatic alpha-Amylase | 分子名称: | ALPHA-AMYLASE, PANCREATIC, CAMELID VHH DOMAIN CAB10 | 著者 | Desmyter, A, Spinelli, S, Payan, F, Lauwereys, M, Wyns, L, Muyldermans, S, Cambillau, C. | 登録日 | 2002-02-01 | 公開日 | 2002-06-19 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology. J.Biol.Chem., 277, 2002
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1R5H
| Crystal Structure of MetAP2 complexed with A320282 | 分子名称: | MANGANESE (II) ION, Methionine aminopeptidase 2, N'-(2S,3R)-3-AMINO-4-CYCLOHEXYL-2-HYDROXY-BUTANO-N-(4-METHYLPHENYL)HYDRAZIDE | 著者 | Sheppard, G.S, Wang, J, Kawai, M, BaMaung, N.Y, Craig, R.A, Erickson, S.A, Lynch, L, Patel, J, Yang, F, Searle, X.B, Lou, P, Park, C, Kim, K.H, Henkin, J, Lesniewski, R. | 登録日 | 2003-10-10 | 公開日 | 2004-10-12 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | 3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2. Bioorg.Med.Chem.Lett., 14, 2004
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1R58
| Crystal Structure of MetAP2 complexed with A357300 | 分子名称: | MANGANESE (II) ION, Methionine aminopeptidase 2, N'-((2S,3R)-3-AMINO-2-HYDROXY-5-(ISOPROPYLSULFANYL)PENTANOYL)-N-3-CHLOROBENZOYL HYDRAZIDE | 著者 | Sheppard, G.S, Wang, J, Kawai, M, BaMaung, N.Y, Craig, R.A, Ericken, S.A, Lynch, L, Patel, J, Yang, F, Searle, X.B, Lou, P, Park, C, Kim, K.H, Henkin, J, Lesniewski, R. | 登録日 | 2003-10-09 | 公開日 | 2004-10-12 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | 3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2. Bioorg.Med.Chem.Lett., 14, 2004
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1KXQ
| Camelid VHH Domain in Complex with Porcine Pancreatic alpha-Amylase | 分子名称: | CALCIUM ION, CHLORIDE ION, alpha-amylase, ... | 著者 | Desmyter, A, Spinelli, S, Payan, F, Lauwereys, M, Wyns, L, Muyldermans, S, Cambillau, C. | 登録日 | 2002-02-01 | 公開日 | 2002-06-19 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology. J.Biol.Chem., 277, 2002
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1R5G
| Crystal Structure of MetAP2 complexed with A311263 | 分子名称: | (2S,3R)-3-AMINO-2-HYDROXY-5-(ETHYLSULFANYL)PENTANOYL-((S)-(-)-(1-NAPHTHYL)ETHYL)AMIDE, MANGANESE (II) ION, Methionine aminopeptidase 2 | 著者 | Sheppard, G.S, Wang, J, Kawai, M, BaMaung, N.Y, Craig, R.A, Erickson, S.A, Lynch, L, Patel, J, Yang, F, Searle, X.B, Lou, P, Park, C, Kim, K.H, Henkin, J, Lesniewski, R. | 登録日 | 2003-10-10 | 公開日 | 2004-10-12 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | 3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2. Bioorg.Med.Chem.Lett., 14, 2004
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1KXT
| Camelid VHH Domains in Complex with Porcine Pancreatic alpha-Amylase | 分子名称: | ALPHA-AMYLASE, PANCREATIC, CALCIUM ION, ... | 著者 | Desmyter, A, Spinelli, S, Payan, F, Lauwereys, M, Wyns, L, Muyldermans, S, Cambillau, C. | 登録日 | 2002-02-01 | 公開日 | 2002-06-19 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology. J.Biol.Chem., 277, 2002
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5XMK
| Cryo-EM structure of the ATP-bound Vps4 mutant-E233Q complex with Vta1 (masked) | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Vacuolar protein sorting-associated protein 4, Vacuolar protein sorting-associated protein VTA1 | 著者 | Sun, S, Li, L, Yang, F, Wang, X, Fan, F, Li, X, Wang, H, Sui, S. | 登録日 | 2017-05-15 | 公開日 | 2017-08-09 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.18 Å) | 主引用文献 | Cryo-EM structures of the ATP-bound Vps4(E233Q) hexamer and its complex with Vta1 at near-atomic resolution Nat Commun, 8, 2017
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