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6Z4Q
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BU of 6z4q by Molmil
Crystal structure of the neurotensin receptor 1 in complex with the small-molecule inverse agonist SR142948A
分子名称: 2-[[5-(2,6-dimethoxyphenyl)-1-[4-[3-(dimethylamino)propyl-methyl-carbamoyl]-2-propan-2-yl-phenyl]pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid, Neurotensin receptor type 1,Neurotensin receptor type 1,DARPin
著者Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
登録日2020-05-25
公開日2021-02-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.923 Å)
主引用文献Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
6ZIN
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BU of 6zin by Molmil
Crystal structure of the neurotensin receptor 1 in complex with the small molecule inverse agonist SR48692
分子名称: 2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid, Neurotensin receptor type 1,DARPin,HRV 3C protease recognition sequence
著者Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
登録日2020-06-26
公開日2021-02-10
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.639 Å)
主引用文献Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
6Z8N
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BU of 6z8n by Molmil
Crystal structure of the neurotensin receptor 1 in complex with the small-molecule full agonist SRI-9829
分子名称: (2~{S})-4-methyl-2-[(1-quinolin-8-ylsulfonylindol-3-yl)carbonylamino]pentanoic acid, Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor 1 (NTSR1),Neurotensin receptor 1 (NTSR1)
著者Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
登録日2020-06-02
公開日2021-02-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.803 Å)
主引用文献Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
6YVR
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BU of 6yvr by Molmil
Crystal structure of the neurotensin receptor 1 in complex with the peptide full agonist NTS8-13
分子名称: Neurotensin receptor type 1,Neurotensin receptor type 1,DARPin crystallisation chaperone, neurotensin NTS8-13 (full agonist), nonyl beta-D-glucopyranoside
著者Deluigi, M, Merklinger, L, Hilge, M, Ernst, P, Klipp, A, Klenk, C, Plueckthun, A.
登録日2020-04-28
公開日2021-02-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.458 Å)
主引用文献Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
6Z4S
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BU of 6z4s by Molmil
Crystal structure of the neurotensin receptor 1 (NTSR1-H4bmx) in complex with the small molecule inverse agonist SR48692
分子名称: 2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid, Neurotensin receptor type 1,DARPin,HRV 3C protease recognition sequence
著者Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
登録日2020-05-25
公開日2021-02-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.707 Å)
主引用文献Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
6Z66
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BU of 6z66 by Molmil
Crystal structure of apo-state neurotensin receptor 1
分子名称: Neurotensin receptor type 1,Neurotensin receptor type 1,DARPin
著者Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
登録日2020-05-27
公開日2021-02-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.192 Å)
主引用文献Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
6ZA8
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BU of 6za8 by Molmil
Crystal structure of the neurotensin receptor 1 in complex with the small-molecule partial agonist RTI-3a
分子名称: (2~{S})-2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]-4-methyl-pentanoic acid, Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor 1 (NTSR1),Neurotensin receptor 1 (NTSR1),Neurotensin receptor type 1,Neurotensin receptor 1 (NTSR1),Neurotensin receptor 1 (NTSR1)
著者Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
登録日2020-06-05
公開日2021-02-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.72 Å)
主引用文献Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
6Z4V
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BU of 6z4v by Molmil
Crystal structure of the neurotensin receptor 1 (NTSR1-H4bmx) in complex with NTS8-13
分子名称: ARG-PRO-TYR-ILE-LEU, Neurotensin receptor type 1,Neurotensin receptor type 1,DARPin
著者Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
登録日2020-05-25
公開日2021-02-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.595 Å)
主引用文献Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
7ZYU
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BU of 7zyu by Molmil
HDAC6 ZnF domain inhibitor - DARPin (Designed Ankyrin repeat protein) F10
分子名称: 1,2-ETHANEDIOL, Designed Ankyrin repeat protein F10, Histone deacetylase 6, ...
著者Wang, L, Kempf, G.
登録日2022-05-25
公開日2022-06-01
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献Disrupting the HDAC6-ubiquitin interaction impairs infection by influenza and Zika virus and cellular stress pathways.
Cell Rep, 39, 2022
4PLR
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BU of 4plr by Molmil
Crystal Structures of Designed Armadillo Repeat Proteins: Implications of Construct Design and Crystallization Conditions on Overall Structure.
分子名称: Arm00008, CALCIUM ION
著者Reichen, C, Madhurantakam, C, Plueckthun, A, Mittl, P.
登録日2014-05-19
公開日2014-08-27
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structures of designed armadillo repeat proteins: Implications of construct design and crystallization conditions on overall structure.
Protein Sci., 23, 2014
4PLS
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BU of 4pls by Molmil
Crystal Structures of Designed Armadillo Repeat Proteins: Implications of Construct Design and Crystallization Conditions on Overall Structure.
分子名称: ACETATE ION, Arm00010, CALCIUM ION
著者Reichen, C, Madhurantakam, C, Plueckthun, A, Mittl, P.R.
登録日2014-05-19
公開日2014-12-10
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal Structures of Designed Armadillo Repeat Proteins: Implications of Construct Design and Crystallization Conditions on Overall Structure.
Protein Sci., 23, 2014
1KP5
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BU of 1kp5 by Molmil
Cyclic Green Fluorescent Protein
分子名称: Green Fluorescent Protein, SULFATE ION
著者Hofmann, A, Iwai, H, Plueckthun, A, Wlodawer, A.
登録日2001-12-28
公開日2002-08-28
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of cyclized green fluorescent protein.
Acta Crystallogr.,Sect.D, 58, 2002
1KTR
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BU of 1ktr by Molmil
Crystal Structure of the Anti-His Tag Antibody 3D5 Single-Chain Fragment (scFv) in Complex with a Oligohistidine peptide
分子名称: Anti-his tag antibody 3d5 variable light chain, Peptide linker, Anti-his tag antibody 3d5 variable heavy chain, ...
著者Kaufmann, M, Lindner, P, Honegger, A, Blank, K, Tschopp, M, Capitani, G, Plueckthun, A, Gruetter, M.G.
登録日2002-01-17
公開日2002-05-15
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of the anti-His tag antibody 3D5 single-chain fragment complexed to its antigen.
J.Mol.Biol., 318, 2002
6ZQK
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BU of 6zqk by Molmil
HER2-binding scFv-Fab fusion 841
分子名称: 1,2-ETHANEDIOL, 841 heavy chain, 841 light chain
著者Kast, F, Schwill, M, Stueber, J.C, Pfundstein, S, Nagy-Davidescu, G, Monne Rodriguez, J.M, Seehusen, F, Richter, C.P, Honegger, A, Hartmann, K.P, Weber, T.G, Kroener, F, Ernst, P, Piehler, J, Plueckthun, A.
登録日2020-07-09
公開日2021-06-30
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action.
Nat Commun, 12, 2021
7B6W
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BU of 7b6w by Molmil
Crystal structure of the human alpha1B adrenergic receptor in complex with inverse agonist (+)-cyclazosin
分子名称: Alpha-1B adrenergic receptor,alpha1B adrenergic receptor,Alpha-1B adrenergic receptor,alpha1B adrenergic receptor,Alpha-1B adrenergic receptor,alpha1B adrenergic receptor,Alpha-1B adrenergic receptor,alpha1B adrenergic receptor, [(4~{a}~{R},8~{a}~{S})-4-(4-azanyl-6,7-dimethoxy-quinazolin-2-yl)-2,3,4~{a},5,6,7,8,8~{a}-octahydroquinoxalin-1-yl]-(furan-2-yl)methanone
著者Deluigi, M, Morstein, L, Hilge, M, Schuster, M, Merklinger, L, Klipp, A, Scott, D.J, Plueckthun, A.
登録日2020-12-08
公開日2022-01-12
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.873 Å)
主引用文献Crystal structure of the alpha 1B -adrenergic receptor reveals molecular determinants of selective ligand recognition.
Nat Commun, 13, 2022
5EYL
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BU of 5eyl by Molmil
TUBULIN-BINDING DARPIN
分子名称: DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN), GLYCEROL, PHOSPHATE ION
著者Ahmad, S, Kossow, M, Gigant, B.
登録日2015-11-25
公開日2016-07-20
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin.
Sci Rep, 6, 2016
5EYP
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BU of 5eyp by Molmil
TUBULIN-DARPIN COMPLEX
分子名称: DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN), GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ...
著者Ahmad, S, Knossow, M, Gigant, B.
登録日2015-11-25
公開日2016-07-20
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin.
Sci Rep, 6, 2016
8AK1
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BU of 8ak1 by Molmil
Crystal structure of a CagI:K2 complex
分子名称: Cag pathogenicity island protein (Cag19), Designed Ankyrin Repeat Protein K2
著者Blanc, M, Guerin, J, Terradot, L.
登録日2022-07-29
公開日2023-05-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system.
Plos Pathog., 19, 2023
8AIW
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BU of 8aiw by Molmil
Structure of the K5/CagI complex
分子名称: Cag pathogenicity island protein (Cag19), Designed Ankyrin Repeat Protein K5
著者Blanc, M, Guerin, J, Terradot, L.
登録日2022-07-27
公開日2023-05-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system.
Plos Pathog., 19, 2023
8AED
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BU of 8aed by Molmil
Broadly neutralizing DARPin bnD.9 in complex with the HIV-1 envelope variable loop 3 peptide V3 (BG505)
分子名称: 1,2-ETHANEDIOL, ACETATE ION, Broadly neutralizing DARPin bnD.9, ...
著者Mittl, P, Gloegl, M.
登録日2022-07-13
公開日2023-08-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.17 Å)
主引用文献Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization.
Nat.Struct.Mol.Biol., 30, 2023
8OH7
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BU of 8oh7 by Molmil
Structure of A4M4C bound to (KR)4 Solution backbone structure refined by PCS
分子名称: Designed Armadillo repeat protein with four internal modules
著者Cucuzza, S, Zerbe, O.
登録日2023-03-20
公開日2023-12-13
実験手法SOLUTION NMR
主引用文献Unexpected dynamics in femtomolar complexes of binding proteins with peptides.
Nat Commun, 14, 2023
7R0R
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BU of 7r0r by Molmil
Solution structure of the designed Armadillo repeat protein N(A4)M4C(AII) refined by pseudocontact shifts
分子名称: Designed Armadillo Repeat Protein N(A4)M4C(AII)
著者Cucuzza, S, Zerbe, O.
登録日2022-02-02
公開日2022-06-22
最終更新日2023-01-25
実験手法SOLUTION NMR
主引用文献Improved Repeat Protein Stability by Combined Consensus and Computational Protein Design.
Biochemistry, 62, 2023
2QYJ
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BU of 2qyj by Molmil
Crystal structure of a designed full consensus ankyrin
分子名称: SULFATE ION, ankyrin NI3C
著者Merz, T.
登録日2007-08-15
公開日2007-11-13
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Stabilizing ionic interactions in a full-consensus ankyrin repeat protein.
J.Mol.Biol., 376, 2008
5LE2
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BU of 5le2 by Molmil
Crystal structure of DARPin-DARPin rigid fusion, variant DDD_D12_15_D12_15_D12
分子名称: ACETATE ION, DDD_D12_15_D12_15_D12, THIOCYANATE ION
著者Batyuk, A, Wu, Y, Mittl, P.R, Plueckthun, A.
登録日2016-06-29
公開日2017-08-02
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Rigidly connected multispecific artificial binders with adjustable geometries.
Sci Rep, 7, 2017
5LEC
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BU of 5lec by Molmil
Crystal structure of DARPin-DARPin rigid fusion, variant DDD_D12_12_D12_12_D12
分子名称: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DDD_D12_12_D12_12_D12
著者Batyuk, A, Wu, Y, Mittl, P.R, Plueckthun, A.
登録日2016-06-29
公開日2017-08-02
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.506 Å)
主引用文献Rigidly connected multispecific artificial binders with adjustable geometries.
Sci Rep, 7, 2017

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