8AED

Broadly neutralizing DARPin bnD.9 in complex with the HIV-1 envelope variable loop 3 peptide V3 (BG505)

Summary for 8AED

Entry DOI	10.2210/pdb8aed/pdb
Related	7Z7C
Descriptor	Broadly neutralizing DARPin bnD.9, Envelope glycoprotein gp160, 1,2-ETHANEDIOL, ... (7 entities in total)
Functional Keywords	darpin, hiv, de novo protein
Biological source	synthetic construct More
Total number of polymer chains	4
Total formula weight	40380.34
Authors	Mittl, P.,Gloegl, M. (deposition date: 2022-07-13, release date: 2023-08-16, Last modification date: 2023-09-20)
Primary citation	Glogl, M.,Friedrich, N.,Cerutti, G.,Lemmin, T.,Kwon, Y.D.,Gorman, J.,Maliqi, L.,Mittl, P.R.E.,Hesselman, M.C.,Schmidt, D.,Weber, J.,Foulkes, C.,Dingens, A.S.,Bylund, T.,Olia, A.S.,Verardi, R.,Reinberg, T.,Baumann, N.S.,Rusert, P.,Dreier, B.,Shapiro, L.,Kwong, P.D.,Pluckthun, A.,Trkola, A. Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization. Nat.Struct.Mol.Biol., 30:1323-1336, 2023 Cited by PubMed: 37605043 DOI: 10.1038/s41594-023-01062-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.17 Å)

Structure validation