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5ZSD
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BU of 5zsd by Molmil
Crystal structure of monkey TLR7 in complex with IMDQ and GGUUGG
分子名称: 1-[[4-(aminomethyl)phenyl]methyl]-2-butyl-imidazo[4,5-c]quinolin-4-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2018-04-28
公開日2019-01-30
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.603 Å)
主引用文献Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.
Cell Rep, 25, 2018
5ZSM
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BU of 5zsm by Molmil
Crystal structure of monkey TLR7 in complex with GGUCCC
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-9-[(2S,3aR,4R,6R,6aR)-2-hydroxy-6-(hydroxymethyl)-2-oxotetrahydro-2H-2lambda~5~-furo[3,4-d][1,3,2]dioxaphosphol-4-yl]-3,9-dihydro-6H-purin-6-one, ...
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2018-04-28
公開日2019-01-30
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.
Cell Rep, 25, 2018
5ZSB
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BU of 5zsb by Molmil
Crystal structure of monkey TLR7 in complex with IMDQ and AAUUAA
分子名称: 1-[[4-(aminomethyl)phenyl]methyl]-2-butyl-imidazo[4,5-c]quinolin-4-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2018-04-28
公開日2019-01-30
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.
Cell Rep, 25, 2018
5ZSF
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BU of 5zsf by Molmil
Crystal structure of monkey TLR7 in complex with imiquimod
分子名称: 1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2018-04-28
公開日2019-01-30
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.
Cell Rep, 25, 2018
5ZSA
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BU of 5zsa by Molmil
Crystal structure of monkey TLR7 in complex with IMDQ and UUUUUU
分子名称: 1-[[4-(aminomethyl)phenyl]methyl]-2-butyl-imidazo[4,5-c]quinolin-4-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2018-04-28
公開日2019-01-30
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.
Cell Rep, 25, 2018
5ZSG
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BU of 5zsg by Molmil
Crystal structure of monkey TLR7 in complex with gardiquimod
分子名称: 1-{4-amino-2-[(ethylamino)methyl]-1H-imidazo[4,5-c]quinolin-1-yl}-2-methylpropan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2018-04-28
公開日2019-01-30
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.
Cell Rep, 25, 2018
5ZSJ
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BU of 5zsj by Molmil
Crystal structure of monkey TLR7 in complex with GS9620
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-azanyl-2-butoxy-8-[[3-(pyrrolidin-1-ylmethyl)phenyl]methyl]-5,7-dihydropteridin-6-one, ...
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2018-04-28
公開日2019-01-30
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.
Cell Rep, 25, 2018
5ZSI
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BU of 5zsi by Molmil
Crystal structure of monkey TLR7 in complex with CL097
分子名称: 2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-4-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2018-04-28
公開日2019-01-30
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.
Cell Rep, 25, 2018
5ZSN
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BU of 5zsn by Molmil
Crystal structure of monkey TLR7 in complex with AAUUAA
分子名称: 2',3'- cyclic AMP, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2018-04-28
公開日2019-01-30
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.
Cell Rep, 25, 2018
5ZSC
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BU of 5zsc by Molmil
Crystal structure of monkey TLR7 in complex with IMDQ and CCUUCC
分子名称: 1-[[4-(aminomethyl)phenyl]methyl]-2-butyl-imidazo[4,5-c]quinolin-4-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2018-04-28
公開日2019-01-30
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.
Cell Rep, 25, 2018
3W3G
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BU of 3w3g by Molmil
Crystal structure of human TLR8 (unliganded form)
分子名称: (R,R)-2,3-BUTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Tanji, H, Ohto, U, Shimizu, T.
登録日2012-12-21
公開日2013-04-03
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands
Science, 339, 2013
3W3M
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BU of 3w3m by Molmil
Crystal structure of human TLR8 in complex with Resiquimod (R848) crystal form 2
分子名称: 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ...
著者Tanji, H, Ohto, U, Shimizu, T.
登録日2012-12-22
公開日2013-04-03
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands
Science, 339, 2013
3WN4
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BU of 3wn4 by Molmil
Crystal structure of human TLR8 in complex with DS-877
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-butylfuro[2,3-c]quinolin-4-amine, Toll-like receptor 8, ...
著者Tanji, H, Ohto, U, Shimizu, T.
登録日2013-12-02
公開日2014-02-19
最終更新日2022-08-24
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Structure-based design of novel human Toll-like receptor 8 agonists.
Chemmedchem, 9, 2014
3W3J
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BU of 3w3j by Molmil
Crystal structure of human TLR8 in complex with CL097
分子名称: 2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-4-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Tanji, H, Ohto, U, Shimizu, T.
登録日2012-12-22
公開日2013-04-03
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands
Science, 339, 2013
3W3L
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BU of 3w3l by Molmil
Crystal structure of human TLR8 in complex with Resiquimod (R848) crystal form 1
分子名称: 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ...
著者Tanji, H, Ohto, U, Shimizu, T.
登録日2012-12-22
公開日2013-04-03
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands
Science, 339, 2013
3WF2
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BU of 3wf2 by Molmil
Crystal structure of human beta-galactosidase in complex with NBT-DGJ
分子名称: (2R,3S,4R,5S)-N-butyl-3,4,5-trihydroxy-2-(hydroxymethyl)piperidine-1-carbothioamide, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Suzuki, H, Ohto, U, Shimizu, T.
登録日2013-07-16
公開日2014-04-16
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis of pharmacological chaperoning for human beta-galactosidase
to be published
3WF0
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BU of 3wf0 by Molmil
Crystal structure of human beta-galactosidase in complex with 6S-NBI-DGJ
分子名称: (3Z,6S,7R,8S,8aS)-3-(butylimino)hexahydro[1,3]thiazolo[3,4-a]pyridine-6,7,8-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Suzuki, H, Ohto, U, Shimizu, T.
登録日2013-07-16
公開日2014-04-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis of pharmacological chaperoning for human beta-galactosidase
to be published
3W3N
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BU of 3w3n by Molmil
Crystal structure of human TLR8 in complex with Resiquimod (R848) crystal form 3
分子名称: 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
著者Tanji, H, Ohto, U, Shimizu, T.
登録日2012-12-22
公開日2013-04-03
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands
Science, 339, 2013
3WF1
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BU of 3wf1 by Molmil
Crystal structure of human beta-galactosidase in complex with 6S-NBI-GJ
分子名称: (3E,5S,6R,7S,8S,8aS)-3-(butylimino)hexahydro[1,3]thiazolo[3,4-a]pyridine-5,6,7,8-tetrol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Suzuki, H, Ohto, U, Shimizu, T.
登録日2013-07-16
公開日2014-04-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis of pharmacological chaperoning for human beta-galactosidase
to be published
3WEZ
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BU of 3wez by Molmil
Crystal structure of human beta-galactosidase in complex with NOEV
分子名称: (1S,2S,3S,6R)-4-(hydroxymethyl)-6-(octylamino)cyclohex-4-ene-1,2,3-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Suzuki, H, Ohto, U, Shimizu, T.
登録日2013-07-16
公開日2014-04-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Structural basis of pharmacological chaperoning for human beta-galactosidase
to be published
3W3K
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BU of 3w3k by Molmil
Crystal structure of human TLR8 in complex with CL075
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-propyl[1,3]thiazolo[4,5-c]quinolin-4-amine, ...
著者Tanji, H, Ohto, U, Shimizu, T.
登録日2012-12-22
公開日2013-04-03
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands
Science, 339, 2013
3WF3
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BU of 3wf3 by Molmil
Crystal structure of human beta-galactosidase mutant I51T in complex with Galactose
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-galactosidase, ...
著者Suzuki, H, Ohto, U, Shimizu, T.
登録日2013-07-16
公開日2014-04-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural basis of pharmacological chaperoning for human beta-galactosidase
to be published
3WF4
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BU of 3wf4 by Molmil
Crystal structure of human beta-galactosidase mutant I51T in complex with 6S-NBI-DGJ
分子名称: (3Z,6S,7R,8S,8aS)-3-(butylimino)hexahydro[1,3]thiazolo[3,4-a]pyridine-6,7,8-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Suzuki, H, Ohto, U, Shimizu, T.
登録日2013-07-16
公開日2014-04-16
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis of pharmacological chaperoning for human beta-galactosidase
to be published
7YTP
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BU of 7ytp by Molmil
TLR7 in complex with an inhibitor
分子名称: (2R,6R)-4-(8-cyanoquinolin-5-yl)-N-[(3S,4R)-4-fluoranylpyrrolidin-3-yl]-6-methyl-morpholine-2-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2022-08-15
公開日2023-11-15
実験手法ELECTRON MICROSCOPY (2.77 Å)
主引用文献TLR7 in complex with an inhibitor
To Be Published
5Z7Y
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BU of 5z7y by Molmil
Crystal structure of Striga hermonthica HTL7 (ShHTL7)
分子名称: 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, Hyposensitive to light 7, ...
著者Xu, Y, Miyakawa, T, Nakamura, A, Tanokura, M.
登録日2018-01-30
公開日2018-08-29
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural analysis of HTL and D14 proteins reveals the basis for ligand selectivity in Striga.
Nat Commun, 9, 2018

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