8CIJ
| CRYSTAL STRUCTURE OF HUMAN HPK1 (MAP4K1) COMPLEX WITH 2-[8-Amino-7-fluoro-6-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-isoquinolin-3-ylamino]-6-isopropyl-5,6-dihydro-4H-1,6,8a-triaza-azulen-7-one | 分子名称: | 2-[[8-azanyl-7-fluoranyl-6-(8-methyl-2,3-dihydro-1~{H}-pyrido[2,3-b][1,4]oxazin-7-yl)isoquinolin-3-yl]amino]-6-propan-2-yl-5,8-dihydro-4~{H}-pyrazolo[1,5-d][1,4]diazepin-7-one, Mitogen-activated protein kinase kinase kinase kinase 1 | 著者 | Musil, D, Toure, M. | 登録日 | 2023-02-09 | 公開日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.821 Å) | 主引用文献 | Discovery of quinazoline HPK1 inhibitors with high cellular potency. Bioorg.Med.Chem., 92, 2023
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8CDW
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3BSA
| Crystal Structure of HCV NS5B Polymerase with a Novel Pyridazinone Inhibitor | 分子名称: | 2-({3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-(1,3-thiazol-5-yl)-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,2,4-benzothia diazin-7-yl}oxy)acetamide, RNA-directed RNA polymerase | 著者 | Han, Q, Showalter, R.E, Zhao, Q, Kissinger, C.R. | 登録日 | 2007-12-23 | 公開日 | 2008-12-23 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine. Bioorg.Med.Chem.Lett., 18, 2008
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3BKY
| Crystal Structure of Chimeric Antibody C2H7 Fab in complex with a CD20 Peptide | 分子名称: | B-lymphocyte antigen CD20, the Fab fragment of chimeric 2H7, heavy chain, ... | 著者 | Du, J, Zhong, C, Ding, J. | 登録日 | 2007-12-07 | 公開日 | 2008-04-29 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Crystal structure of chimeric antibody C2H7 Fab in complex with a CD20 peptide Mol.Immunol., 45, 2008
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4N4G
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4N4I
| Crystal structure of the Bromo-PWWP of the mouse zinc finger MYND-type containing 11 isoform alpha in complex with histone H3.3K36me3 | 分子名称: | DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, Peptide from Histone H3.3, ... | 著者 | Li, Y, Ren, Y, Li, H. | 登録日 | 2013-10-08 | 公開日 | 2014-03-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.999 Å) | 主引用文献 | ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression Nature, 508, 2014
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4N4H
| Crystal structure of the Bromo-PWWP of the mouse zinc finger MYND-type containing 11 isoform alpha in complex with histone H3.1K36me3 | 分子名称: | DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, Peptide from Histone H3.1, ... | 著者 | Li, Y, Ren, Y, Li, H. | 登録日 | 2013-10-08 | 公開日 | 2014-03-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.302 Å) | 主引用文献 | ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression Nature, 508, 2014
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5FCS
| Diabody | 分子名称: | Diabody, SULFATE ION | 著者 | Mosyak, L, Root, A. | 登録日 | 2015-12-15 | 公開日 | 2016-12-14 | 最終更新日 | 2019-11-13 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer. Antibodies, 5, 2016
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5JJU
| Crystal structure of Rv2837c complexed with 5'-pApA and 5'-AMP | 分子名称: | ADENOSINE MONOPHOSPHATE, MANGANESE (II) ION, RNA (5'-R(P*AP*A)-3'), ... | 著者 | Wang, F, He, Q, Liu, S, Gu, L. | 登録日 | 2016-04-25 | 公開日 | 2016-05-04 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.312 Å) | 主引用文献 | Structural and biochemical insight into the mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP phosphodiesterase J.Biol.Chem., 291, 2016
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2QYF
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5XHS
| Crystal structure of SIRT5 complexed with a fluorogenic small-molecule substrate SuBKA | 分子名称: | (2S)-2-azanyl-6-[(4-hydroxy-4-oxo-butanoyl)amino]hexanoic acid, 7-AMINO-4-METHYL-CHROMEN-2-ONE, NAD-dependent protein deacylase sirtuin-5, ... | 著者 | Yu, Y, Li, B, Chen, Q. | 登録日 | 2017-04-24 | 公開日 | 2018-05-02 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Interactions between sirtuins and fluorogenic small-molecule substrates offer insights into inhibitor design Rsc Adv, 7, 2017
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4WD5
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8XEG
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5JO1
| Crystal structure of phaseic acid-bound abscisic acid receptor PYL3 in complex with type 2C protein phosphatase HAB1 | 分子名称: | (3S,4E)-5-[(1R,5R,8S)-8-hydroxy-1,5-dimethyl-3-oxo-6-oxabicyclo[3.2.1]octan-8-yl]-3-methylpent-4-enoic acid, Abscisic acid receptor PYL3, MAGNESIUM ION, ... | 著者 | Weng, J.K, Noel, J.P. | 登録日 | 2016-05-01 | 公開日 | 2016-09-07 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Co-evolution of Hormone Metabolism and Signaling Networks Expands Plant Adaptive Plasticity. Cell, 166, 2016
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5JO2
| Crystal structure of abscisic acid-bound abscisic acid receptor PYL3 in complex with type 2C protein phosphatase HAB1 | 分子名称: | (2Z,4E)-5-[(1S)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, Abscisic acid receptor PYL3, MAGNESIUM ION, ... | 著者 | Weng, J.K, Noel, J.P. | 登録日 | 2016-05-01 | 公開日 | 2016-09-07 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | Co-evolution of Hormone Metabolism and Signaling Networks Expands Plant Adaptive Plasticity. Cell, 166, 2016
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3KQ6
| Enhancing the Therapeutic Properties of a Protein by a Designed Zinc-Binding Site, Structural principles of a novel long-acting insulin analog | 分子名称: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | 著者 | Wan, Z.L, Hu, S.Q, Whittaker, L, Phillips, N.B, Whittake, J, Ismail-Beigi, F, Weiss, M.A. | 登録日 | 2009-11-17 | 公開日 | 2010-02-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot. J.Biol.Chem., 285, 2010
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7YPX
| Cyanophage Pam3 fiber | 分子名称: | Pam3 tail fiber proreins, tail fiber chaperone | 著者 | Wei, Z.L, Jiang, Y.L, Zhou, C.Z. | 登録日 | 2022-08-04 | 公開日 | 2022-11-09 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | Structural Insights into the Chaperone-Assisted Assembly of a Simplified Tail Fiber of the Myocyanophage Pam3. Viruses, 14, 2022
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8WPZ
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6TYM
| KEAP1 Kelch domain in complex with Compound 9 | 分子名称: | (3S)-3-[2-(benzenecarbonyl)-5-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl]-3-(1-ethyl-4-methyl-1H-benzotriazol-5-yl)propanoic acid, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Marcotte, D.J. | 登録日 | 2019-08-09 | 公開日 | 2020-01-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.422 Å) | 主引用文献 | Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators. Bioorg.Med.Chem.Lett., 30, 2020
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6TYP
| KEAP1 Kelch domain in complex with Compound 2 | 分子名称: | (3S)-3-[2-(benzenecarbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]-3-(1-ethyl-4-methyl-1H-benzotriazol-5-yl)propanoic acid, FORMIC ACID, Kelch-like ECH-associated protein 1 | 著者 | Marcotte, D.J. | 登録日 | 2019-08-09 | 公開日 | 2020-01-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators. Bioorg.Med.Chem.Lett., 30, 2020
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7LJB
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1FEX
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6LIX
| CRL Protein of Arabidopsis | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Chromophore lyase CRL, chloroplastic | 著者 | Wang, F.F, Guan, K.L, Sun, P.K, Xing, W.M. | 登録日 | 2019-12-13 | 公開日 | 2020-09-16 | 最終更新日 | 2020-12-02 | 実験手法 | X-RAY DIFFRACTION (2.385 Å) | 主引用文献 | The Arabidopsis CRUMPLED LEAF protein, a homolog of the cyanobacterial bilin lyase, retains the bilin-binding pocket for a yet unknown function. Plant J., 104, 2020
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6LIY
| SeMet CRL Protein of Arabidopsis | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Chromophore lyase CRL, chloroplastic | 著者 | Wang, F.F, Guan, K.L, Sun, P.K, Xing, W.M. | 登録日 | 2019-12-13 | 公開日 | 2020-09-16 | 最終更新日 | 2020-12-02 | 実験手法 | X-RAY DIFFRACTION (1.761 Å) | 主引用文献 | The Arabidopsis CRUMPLED LEAF protein, a homolog of the cyanobacterial bilin lyase, retains the bilin-binding pocket for a yet unknown function. Plant J., 104, 2020
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3BR9
| Crystal Structure of HCV NS5B Polymerase with a Novel Pyridazinone Inhibitor | 分子名称: | (2R)-2-({3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-thiophen-2-yl-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,2,4-benzothia diazin-7-yl}oxy)propanamide, RNA-directed RNA polymerase | 著者 | Zhao, Q, Showalter, R.E, Han, Q, Kissinger, C.R. | 登録日 | 2007-12-21 | 公開日 | 2008-12-23 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine. Bioorg.Med.Chem.Lett., 18, 2008
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