7D3I
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![BU of 7d3i by Molmil](/molmil-images/mine/7d3i) | Crystal structure of SARS-CoV-2 main protease in complex with MI-23 | 分子名称: | (3~{S},3~{a}~{S},6~{a}~{R})-2-[3-[3,5-bis(fluoranyl)phenyl]propanoyl]-~{N}-[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-3,3~{a},4,5,6,6~{a}-hexahydro-1~{H}-cyclopenta[c]pyrrole-3-carboxamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3C-like proteinase | 著者 | Zeng, R, Li, Y.S, Qiao, J.X, Wang, Y.F, Yang, S.Y, Lei, J. | 登録日 | 2020-09-19 | 公開日 | 2020-10-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.004 Å) | 主引用文献 | SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model. Science, 371, 2021
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7COM
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![BU of 7com by Molmil](/molmil-images/mine/7com) | Crystal structure of the SARS-CoV-2 main protease in complex with Boceprevir (space group P212121) | 分子名称: | 3C-like proteinase, boceprevir (bound form) | 著者 | Zeng, R, Qiao, J.X, Wang, Y.F, Li, Y.S, Yao, R, Liu, J.M, Zhou, Y.L, Chen, P, Yang, S.Y, Lei, J. | 登録日 | 2020-08-04 | 公開日 | 2020-08-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model. Science, 371, 2021
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7YBG
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![BU of 7ybg by Molmil](/molmil-images/mine/7ybg) | |
2V3W
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![BU of 2v3w by Molmil](/molmil-images/mine/2v3w) | Crystal structure of the benzoylformate decarboxylase variant L461A from Pseudomonas putida | 分子名称: | BENZOYLFORMATE DECARBOXYLASE, MAGNESIUM ION, SULFATE ION, ... | 著者 | Gocke, D, Walter, L, Gauchenova, K, Kolter, G, Knoll, M, Berthold, C.L, Schneider, G, Pleiss, J, Mueller, M, Pohl, M. | 登録日 | 2007-06-25 | 公開日 | 2008-01-22 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Rational Protein Design of Thdp-Dependent Enzymes-Engineering Stereoselectivity. Chembiochem, 9, 2008
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8HDA
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![BU of 8hda by Molmil](/molmil-images/mine/8hda) | |
8IZT
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![BU of 8izt by Molmil](/molmil-images/mine/8izt) | |
8IZU
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![BU of 8izu by Molmil](/molmil-images/mine/8izu) | |
8H6L
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![BU of 8h6l by Molmil](/molmil-images/mine/8h6l) | Cryo-EM structure of human exon-defined spliceosome in the early B state. | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y. | 登録日 | 2022-10-18 | 公開日 | 2024-05-01 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural insights into human exon-defined spliceosome prior to activation. Cell Res., 34, 2024
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8H6K
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![BU of 8h6k by Molmil](/molmil-images/mine/8h6k) | Cryo-EM structure of human exon-defined spliceosome in the mature B state. | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y. | 登録日 | 2022-10-18 | 公開日 | 2024-05-01 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural insights into human exon-defined spliceosome prior to activation. Cell Res., 34, 2024
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8H6E
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![BU of 8h6e by Molmil](/molmil-images/mine/8h6e) | Cryo-EM structure of human exon-defined spliceosome in the late pre-B state. | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y. | 登録日 | 2022-10-17 | 公開日 | 2024-05-01 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural insights into human exon-defined spliceosome prior to activation. Cell Res., 34, 2024
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8H6J
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![BU of 8h6j by Molmil](/molmil-images/mine/8h6j) | Cryo-EM structure of human exon-defined spliceosome in the mature pre-B state. | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Zhang, W, Zhan, X, Zhang, X, Lei, J, Yan, C, Shi, Y. | 登録日 | 2022-10-18 | 公開日 | 2024-05-01 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | Structural insights into human exon-defined spliceosome prior to activation. Cell Res., 34, 2024
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5YLZ
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![BU of 5ylz by Molmil](/molmil-images/mine/5ylz) | Cryo-EM Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae at 3.6 angstrom | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | 著者 | Wan, R, Yan, C, Bai, R, Lei, J, Shi, Y. | 登録日 | 2017-10-20 | 公開日 | 2018-07-18 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae Cell, 171, 2017
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5Y88
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![BU of 5y88 by Molmil](/molmil-images/mine/5y88) | Cryo-EM structure of the intron-lariat spliceosome ready for disassembly from S.cerevisiae at 3.5 angstrom | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, Intron lariat, ... | 著者 | Wan, R, Yan, C, Bai, R, Lei, J, Shi, Y. | 登録日 | 2017-08-20 | 公開日 | 2018-08-01 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | 主引用文献 | Structure of an Intron Lariat Spliceosome from Saccharomyces cerevisiae Cell(Cambridge,Mass.), 171, 2017
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7DCO
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![BU of 7dco by Molmil](/molmil-images/mine/7dco) | Cryo-EM structure of the activated spliceosome (Bact complex) at an atomic resolution of 2.5 angstrom | 分子名称: | BJ4_G0014900.mRNA.1.CDS.1, BJ4_G0027490.mRNA.1.CDS.1, BJ4_G0037700.mRNA.1.CDS.1, ... | 著者 | Bai, R, Wan, R, Yan, C, Qi, J, Zhang, P, Lei, J, Shi, Y. | 登録日 | 2020-10-26 | 公開日 | 2021-03-17 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2. Science, 371, 2021
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7DD3
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![BU of 7dd3 by Molmil](/molmil-images/mine/7dd3) | Cryo-EM structure of the pre-mRNA-loaded DEAH-box ATPase/helicase Prp2 in complex with Spp2 | 分子名称: | PRP2 isoform 1, Pre-mRNA-splicing factor SPP2, pre-mRNA | 著者 | Bai, R, Wan, R, Yan, C, Qi, J, Zhang, P, Lei, J, Shi, Y. | 登録日 | 2020-10-27 | 公開日 | 2021-01-06 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2. Science, 371, 2021
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5Z56
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![BU of 5z56 by Molmil](/molmil-images/mine/5z56) | cryo-EM structure of a human activated spliceosome (mature Bact) at 5.1 angstrom. | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | 著者 | Zhang, X, Yan, C, Zhan, X, Li, L, Lei, J, Shi, Y. | 登録日 | 2018-01-17 | 公開日 | 2018-09-19 | 最終更新日 | 2020-10-14 | 実験手法 | ELECTRON MICROSCOPY (5.1 Å) | 主引用文献 | Structure of the human activated spliceosome in three conformational states. Cell Res., 28, 2018
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5Z58
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![BU of 5z58 by Molmil](/molmil-images/mine/5z58) | Cryo-EM structure of a human activated spliceosome (early Bact) at 4.9 angstrom. | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | 著者 | Zhang, X, Yan, C, Zhan, X, Li, L, Lei, J, Shi, Y. | 登録日 | 2018-01-17 | 公開日 | 2018-09-19 | 最終更新日 | 2020-10-14 | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | 主引用文献 | Structure of the human activated spliceosome in three conformational states. Cell Res., 28, 2018
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5Z57
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![BU of 5z57 by Molmil](/molmil-images/mine/5z57) | Cryo-EM structure of the human activated spliceosome (late Bact) at 6.5 angstrom | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, ALANINE, BUD13 homolog, ... | 著者 | Zhang, X, Yan, C, Zhan, X, Li, L, Lei, J, Shi, Y. | 登録日 | 2018-01-17 | 公開日 | 2018-09-19 | 最終更新日 | 2020-10-14 | 実験手法 | ELECTRON MICROSCOPY (6.5 Å) | 主引用文献 | Structure of the human activated spliceosome in three conformational states. Cell Res., 28, 2018
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5YZG
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![BU of 5yzg by Molmil](/molmil-images/mine/5yzg) | The Cryo-EM Structure of Human Catalytic Step I Spliceosome (C complex) at 4.1 angstrom resolution | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Zhan, X, Yan, C, Zhang, X, Lei, J, Shi, Y. | 登録日 | 2017-12-14 | 公開日 | 2018-08-08 | 最終更新日 | 2020-10-14 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structure of a human catalytic step I spliceosome Science, 359, 2018
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6A70
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![BU of 6a70 by Molmil](/molmil-images/mine/6a70) | Structure of the human PKD1/PKD2 complex | 分子名称: | Polycystin-1, Polycystin-2 | 著者 | Su, Q, Hu, F, Ge, X, Lei, J, Yu, S, Wang, T, Zhou, Q, Mei, C, Shi, Y. | 登録日 | 2018-06-29 | 公開日 | 2018-08-15 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure of the human PKD1-PKD2 complex. Science, 361, 2018
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5ZWN
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![BU of 5zwn by Molmil](/molmil-images/mine/5zwn) | Cryo-EM structure of the yeast pre-B complex at an average resolution of 3.3 angstrom (Part II: U1 snRNP region) | 分子名称: | 56 kDa U1 small nuclear ribonucleoprotein component, Pre-mRNA-processing factor 39, Pre-mRNA-splicing ATP-dependent RNA helicase PRP28, ... | 著者 | Bai, R, Wan, R, Yan, C, Lei, J, Shi, Y. | 登録日 | 2018-05-16 | 公開日 | 2018-08-29 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structures of the fully assembledSaccharomyces cerevisiaespliceosome before activation Science, 360, 2018
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5ZWM
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![BU of 5zwm by Molmil](/molmil-images/mine/5zwm) | Cryo-EM structure of the yeast pre-B complex at an average resolution of 3.4~4.6 angstrom (tri-snRNP and U2 snRNP Part) | 分子名称: | 13 kDa ribonucleoprotein-associated protein, 66 kDa U4/U6.U5 small nuclear ribonucleoprotein component, Cold sensitive U2 snRNA suppressor 1, ... | 著者 | Bai, R, Wan, R, Yan, C, Lei, J, Shi, Y. | 登録日 | 2018-05-16 | 公開日 | 2018-08-29 | 最終更新日 | 2019-11-06 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structures of the fully assembledSaccharomyces cerevisiaespliceosome before activation Science, 360, 2018
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7VNU
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![BU of 7vnu by Molmil](/molmil-images/mine/7vnu) | |
6J6G
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![BU of 6j6g by Molmil](/molmil-images/mine/6j6g) | Cryo-EM structure of the yeast B*-a2 complex at an average resolution of 3.2 angstrom | 分子名称: | ACT1 pre-mRNA, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | 登録日 | 2019-01-15 | 公開日 | 2019-04-24 | 最終更新日 | 2020-10-14 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching. Cell, 177, 2019
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6J8I
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![BU of 6j8i by Molmil](/molmil-images/mine/6j8i) | Structure of human voltage-gated sodium channel Nav1.7 in complex with auxiliary beta subunits, ProTx-II and tetrodotoxin (Y1755 up) | 分子名称: | (1R,5R,6R,7R,9S,11S,12S,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol (non-preferred name), 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Shen, H, Liu, D, Lei, J, Yan, N. | 登録日 | 2019-01-19 | 公開日 | 2019-02-27 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins. Science, 363, 2019
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