7DII
 
 | | Crystal structure of LeuT in lipidic cubic phase at pH 7 | | 分子名称: | LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION | | 著者 | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | | 登録日 | 2020-11-19 | | 公開日 | 2021-04-07 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.403 Å) | | 主引用文献 | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states.
J.Biol.Chem., 296, 2021
|
|
7DJ2
 | | Crystal structure of the G26C/E290S mutant of LeuT | | 分子名称: | LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ... | | 著者 | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | | 登録日 | 2020-11-19 | | 公開日 | 2021-04-07 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states.
J.Biol.Chem., 296, 2021
|
|
7DJC
 | | Crystal structure of the G26C/Q250A mutant of LeuT | | 分子名称: | LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ... | | 著者 | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | | 登録日 | 2020-11-20 | | 公開日 | 2021-04-07 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.701 Å) | | 主引用文献 | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states.
J.Biol.Chem., 296, 2021
|
|
8W4C
 | | The sigma-1 receptor from Xenopus laevis in complex with progesterone by soaking | | 分子名称: | PROGESTERONE, Sigma non-opioid intracellular receptor 1 | | 著者 | Xiao, Y, Fu, C, Sun, Z, Zhou, X. | | 登録日 | 2023-08-23 | | 公開日 | 2024-07-17 | | 実験手法 | X-RAY DIFFRACTION (2.676 Å) | | 主引用文献 | Insight into binding of endogenous neurosteroid ligands to the sigma-1 receptor.
Nat Commun, 15, 2024
|
|
8W4B
 | | The sigma-1 receptor from Xenopus laevis in complex with progesterone by co-crystallization | | 分子名称: | PROGESTERONE, Sigma non-opioid intracellular receptor 1 | | 著者 | Xiao, Y, Fu, C, Sun, Z, Zhou, X. | | 登録日 | 2023-08-23 | | 公開日 | 2024-07-17 | | 実験手法 | X-RAY DIFFRACTION (2.152 Å) | | 主引用文献 | Insight into binding of endogenous neurosteroid ligands to the sigma-1 receptor.
Nat Commun, 15, 2024
|
|
8W4E
 | |
8W4D
 | |
4ZS3
 | | Structural complex of 5-aminofluorescein bound to the FTO protein | | 分子名称: | 2-OXOGLUTARIC ACID, 5-amino-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid, Alpha-ketoglutarate-dependent dioxygenase FTO, ... | | 著者 | Wang, T, Hong, T, Huang, Y, Yang, C.G, Zhou, X. | | 登録日 | 2015-05-13 | | 公開日 | 2015-11-04 | | 最終更新日 | 2015-11-18 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein
J.Am.Chem.Soc., 137, 2015
|
|
4ZS2
 | | Structural complex of FTO/fluorescein | | 分子名称: | 2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-BENZOIC ACID, 2-OXOGLUTARIC ACID, Alpha-ketoglutarate-dependent dioxygenase FTO, ... | | 著者 | Wang, T, Hong, T, Huang, Y, Yang, C.G, Zhou, X. | | 登録日 | 2015-05-13 | | 公開日 | 2015-11-04 | | 最終更新日 | 2015-11-18 | | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | | 主引用文献 | Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein
J.Am.Chem.Soc., 137, 2015
|
|
5H3O
 | | Structure of a eukaryotic cyclic nucleotide-gated channel | | 分子名称: | CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel, SODIUM ION | | 著者 | Li, M, Zhou, X, Wang, S, Michailidis, I, Gong, Y, Su, D, Li, H, Li, X, Yang, J. | | 登録日 | 2016-10-26 | | 公開日 | 2017-01-25 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structure of a eukaryotic cyclic-nucleotide-gated channel.
Nature, 542, 2017
|
|
7TAK
 | | Structure of a NAT transporter | | 分子名称: | GUANINE, Putative membrane protein PurT | | 著者 | Weng, J, Zhou, X, Ren, Z, Chen, K, Zhou, M. | | 登録日 | 2021-12-21 | | 公開日 | 2023-01-25 | | 最終更新日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (2.79828 Å) | | 主引用文献 | Insight into the mechanism of H + -coupled nucleobase transport.
Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
4Z0B
 | | Crystal Structure of the Fab Fragment of Anti-ofloxacin Antibody and Exploration Its Receptor Binding Site | | 分子名称: | PHOSPHATE ION, antibody heavy chain, antibody light chain | | 著者 | He, K, Du, X, Sheng, W, Zhou, X, Wang, J, Wang, S. | | 登録日 | 2015-03-26 | | 公開日 | 2016-04-27 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Crystal Structure of the Fab Fragment of an Anti-ofloxacin Antibody and Exploration of Its Specific Binding.
J.Agric.Food Chem., 64, 2016
|
|
5U6I
 | | Discovery of MLi-2, an Orally Available and Selective LRRK2 Inhibitor that Reduces Brain Kinase Activity | | 分子名称: | 3-[2-(morpholin-4-yl)pyridin-4-yl]-5-[(propan-2-yl)oxy]-1H-indazole, Mitogen-activated protein kinase 1, SULFATE ION | | 著者 | Scott, J.D, DeMong, D.E, Fell, M.J, Mirescu, C, Basu, K, Greshock, T.J, Morrow, J.A, Xiao, L, Hruza, A, Harris, J, Tiscia, H.E, Chang, R.K, Embrey, M.W, McCauley, J.A, Li, W, Lin, S, Liu, H, Dai, X, Baptista, M, Agnihotri, G, Columbus, J, Mei, H, Poirier, M, Zhou, X, Lin, Y, Yin, Z, Sanders, J.M, Drolet, R.E, Kern, J.T, Kennedy, M.E, Parker, E.M, Stamford, A.W, Nargund, R, Miller, M.W. | | 登録日 | 2016-12-08 | | 公開日 | 2017-03-15 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity.
J. Med. Chem., 60, 2017
|
|
5TJB
 | | I-II linker of TRPML1 channel at pH 4.5 | | 分子名称: | Mucolipin-1 | | 著者 | Li, M, Zhang, W.K, Benvin, N.M, Zhou, X, Su, D, Li, H, Wang, S, Michailidis, I.E, Tong, L, Li, X, Yang, J. | | 登録日 | 2016-10-04 | | 公開日 | 2017-01-25 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis of dual Ca(2+)/pH regulation of the endolysosomal TRPML1 channel.
Nat. Struct. Mol. Biol., 24, 2017
|
|
5TJA
 | | I-II linker of TRPML1 channel at pH 6 | | 分子名称: | Mucolipin-1 | | 著者 | Li, M, Zhang, W.K, Benvin, N.M, Zhou, X, Su, D, Li, H, Wang, S, Michailidis, I.E, Tong, L, Li, X, Yang, J. | | 登録日 | 2016-10-04 | | 公開日 | 2017-01-25 | | 最終更新日 | 2019-12-18 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural basis of dual Ca(2+)/pH regulation of the endolysosomal TRPML1 channel.
Nat. Struct. Mol. Biol., 24, 2017
|
|
5TJC
 | | I-II linker of TRPML1 channel at pH 7.5 | | 分子名称: | Mucolipin-1 | | 著者 | Li, M, Zhang, W.K, Benvin, N.M, Zhou, X, Su, D, Li, H, Wang, S, Michailidis, I.E, Tong, L, Li, X, Yang, J. | | 登録日 | 2016-10-04 | | 公開日 | 2017-01-25 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis of dual Ca(2+)/pH regulation of the endolysosomal TRPML1 channel.
Nat. Struct. Mol. Biol., 24, 2017
|
|
4LA1
 | | Crystal structure of SjTGR (thioredoxin glutathione reductase from Schistosoma japonicumi)complex with FAD | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Thioredoxin glutathione reductase | | 著者 | Peng, Y, Wu, Q, Huang, F, Chen, J, Li, X, Zhou, X, Fan, X. | | 登録日 | 2013-06-18 | | 公開日 | 2014-07-30 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.348 Å) | | 主引用文献 | Crystal structure of SjTGR complex with FAD
To be Published
|
|
1SZS
 | | The structure of gamma-aminobutyrate aminotransferase mutant: I50Q | | 分子名称: | 1,2-ETHANEDIOL, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, 4-aminobutyrate aminotransferase, ... | | 著者 | Liu, W, Peterson, P.E, Langston, J.A, Jin, X, Zhou, X, Fisher, A.J, Toney, M.D. | | 登録日 | 2004-04-06 | | 公開日 | 2005-03-01 | | 最終更新日 | 2021-10-27 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Kinetic and Crystallographic Analysis of Active Site Mutants of Escherichia coligamma-Aminobutyrate Aminotransferase.
Biochemistry, 44, 2005
|
|
1SZU
 | | The structure of gamma-aminobutyrate aminotransferase mutant: V241A | | 分子名称: | 1,2-ETHANEDIOL, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, 4-aminobutyrate aminotransferase, ... | | 著者 | Liu, W, Peterson, P.E, Langston, J.A, Jin, X, Zhou, X, Fisher, A.J, Toney, M.D. | | 登録日 | 2004-04-06 | | 公開日 | 2005-03-01 | | 最終更新日 | 2021-10-27 | | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | | 主引用文献 | Kinetic and Crystallographic Analysis of Active Site Mutants of Escherichia coligamma-Aminobutyrate Aminotransferase.
Biochemistry, 44, 2005
|
|
4GAZ
 | | Crystal Structure of a Jumonji Domain-containing Protein JMJD5 | | 分子名称: | Lysine-specific demethylase 8, N-OXALYLGLYCINE, NICKEL (II) ION | | 著者 | Wang, H, Zhou, X, Zhang, X, Tao, Y, Chen, N, Zang, J. | | 登録日 | 2012-07-26 | | 公開日 | 2013-08-14 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | Crystal Structure of a Jumonji Domain-containing Protein JMJD5
To be Published
|
|
3ESW
 | | Complex of yeast PNGase with GlcNAc2-IAc. | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase, UV excision repair protein RAD23, ... | | 著者 | Zhao, G, Zhou, X, Lennarz, W.J, Schindelin, H. | | 登録日 | 2008-10-06 | | 公開日 | 2008-11-11 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Structural and mutational studies on the importance of oligosaccharide binding for the activity of yeast PNGase.
Glycobiology, 19, 2009
|
|
3HH7
 | | Structural and Functional Characterization of a Novel Homodimeric Three-finger Neurotoxin from the Venom of Ophiophagus hannah (King Cobra) | | 分子名称: | Muscarinic toxin-like protein 3 homolog | | 著者 | Roy, A, Zhou, X, Chong, M.Z, D'hoedt, D, Foo, C.S, Rajagopalan, N, Nirthanan, S, Bertrand, D, Sivaraman, J, Kini, R.M. | | 登録日 | 2009-05-15 | | 公開日 | 2010-01-12 | | 最終更新日 | 2017-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Structural and Functional Characterization of a Novel Homodimeric Three-finger Neurotoxin from the Venom of Ophiophagus hannah (King Cobra)
J.Biol.Chem., 285, 2010
|
|
7Y96
 | |
7Y9B
 | | Crystal structure of the membrane (M) protein of a SARS-COV-2-related coronavirus | | 分子名称: | 3,6,9,12,15-PENTAOXATRICOSAN-1-OL, Membrane protein | | 著者 | Wang, X, Sun, Z, Zhou, X. | | 登録日 | 2022-06-24 | | 公開日 | 2022-08-17 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.214 Å) | | 主引用文献 | Crystal structure of the membrane (M) protein from a bat betacoronavirus.
Pnas Nexus, 2, 2023
|
|
2F4M
 | | The Mouse PNGase-HR23 Complex Reveals a Complete Remodulation of the Protein-Protein Interface Compared to its Yeast Orthologs | | 分子名称: | CHLORIDE ION, UV excision repair protein RAD23 homolog B, ZINC ION, ... | | 著者 | Zhao, G, Zhou, X, Wang, L, Kisker, C, Lennarz, W.J, Schindelin, H. | | 登録日 | 2005-11-23 | | 公開日 | 2006-03-07 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structure of the mouse peptide N-glycanase-HR23 complex suggests co-evolution of the endoplasmic reticulum-associated degradation and DNA repair pathways.
J.Biol.Chem., 281, 2006
|
|
