6I3G
 
 | | Crystal structure of a putative peptide binding protein AppA from Clostridium difficile | | 分子名称: | ABC transporter, substrate-binding protein, family 5, ... | | 著者 | Hughes, A.M, Wilkinson, A, Dodson, E. | | 登録日 | 2018-11-06 | | 公開日 | 2019-04-10 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of the putative peptide-binding protein AppA from Clostridium difficile.
Acta Crystallogr.,Sect.F, 75, 2019
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4V4F
 | | The structure of the trp RNA-binding attenuation protein (TRAP) bound to a RNA molecule containing UAGAU repeats | | 分子名称: | 5'-R(*UP*AP*GP*AP*UP)-3', TRANSCRIPTION ATTENUATION PROTEIN MTRB, TRYPTOPHAN | | 著者 | Hopcroft, N.H, Manfredo, A, Wendt, A.L, Brzozowski, A.M, Gollnick, P, Antson, A.A. | | 登録日 | 2003-12-08 | | 公開日 | 2014-07-09 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The Interaction of RNA with Trap: The Role of Triplet Repeats and Separating Spacer Nucleotides
J.Mol.Biol., 338, 2004
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3KQ6
 | | Enhancing the Therapeutic Properties of a Protein by a Designed Zinc-Binding Site, Structural principles of a novel long-acting insulin analog | | 分子名称: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | | 著者 | Wan, Z.L, Hu, S.Q, Whittaker, L, Phillips, N.B, Whittake, J, Ismail-Beigi, F, Weiss, M.A. | | 登録日 | 2009-11-17 | | 公開日 | 2010-02-23 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot.
J.Biol.Chem., 285, 2010
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3GKY
 | | The Structural Basis of an ER Stress-Associated Bottleneck in a Protein Folding Landscape | | 分子名称: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | | 著者 | Liu, M, Wan, Z.L, Chu, Y.C, Alddin, H, Klaproth, B, Weiss, M.A. | | 登録日 | 2009-03-11 | | 公開日 | 2009-03-24 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure of a "nonfoldable" insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITY.
J.Biol.Chem., 284, 2009
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1XW7
 | | Diabetes-Associated Mutations in Human Insulin: Crystal Structure and Photo-Cross-Linking Studies of A-Chain Variant Insulin Wakayama | | 分子名称: | CHLORIDE ION, Insulin, PHENOL, ... | | 著者 | Wan, Z.L, Huang, K, Xu, B, Chu, Y.C, Hu, S.Q, Katsoyannis, P.G, Weiss, M.A. | | 登録日 | 2004-10-29 | | 公開日 | 2005-04-12 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin wakayama
Biochemistry, 44, 2005
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1TRZ
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3V1G
 | | Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health | | 分子名称: | CHLORIDE ION, Insulin, PHENOL, ... | | 著者 | Wan, Z.L, Hua, Q.X, Wickramasinghe, N.P, Huang, K, Petkova, A.T, Hu, S.Q, Phillips, N.B, Yeh, I.J, Whittake, J, Ismail-Beigi, F, Katsoyyannis, P.G, Tycko, R, Weiss, M.A. | | 登録日 | 2011-12-09 | | 公開日 | 2012-12-12 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Forestalling insulin fibrillation by insertion of a
chiral clamp mechanism-based application of protein engineering to global health
To be Published
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3V19
 | | Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health | | 分子名称: | CHLORIDE ION, Insulin, PHENOL, ... | | 著者 | Wan, Z.L, Hua, Q.X, Wickramasinghe, N.P, Huang, K, Petkova, A.T, Hu, S.Q, Phillips, N.B, Yeh, I.J, Whittake, J, Ismail-Beigi, F, Katsoyyannis, P.G, Tycko, R, Weiss, M.A. | | 登録日 | 2011-12-09 | | 公開日 | 2012-12-12 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Forestalling insulin fibrillation by insertion of a
chiral clamp mechanism-based application of protein engineering to global health
To be Published
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3FQ9
 | | Design of an insulin analog with enhanced receptor-binding selectivity. Rationale, structure, and therapeutic implications | | 分子名称: | Insulin, ZINC ION | | 著者 | Zhao, M, Wan, Z.L, Whittaker, L, Xu, B, Phillips, N, Katsoyannis, P, Whittaker, J, Weiss, M.A. | | 登録日 | 2009-01-07 | | 公開日 | 2009-08-04 | | 最終更新日 | 2024-11-27 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications.
J.Biol.Chem., 284, 2009
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2HF0
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1MYJ
 | | DISTAL POLARITY IN LIGAND BINDING TO MYOGLOBIN: STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF A THREONINE68(E11) MUTANT | | 分子名称: | MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | | 著者 | Smerdon, S.J, Oldfield, T.J, Wilkinson, A.J, Dauter, Z, Petratos, K, Wilson, K.S. | | 登録日 | 1992-02-27 | | 公開日 | 1994-01-31 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Distal pocket polarity in ligand binding to myoglobin: structural and functional characterization of a threonine68(E11) mutant.
Biochemistry, 30, 1991
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2HEZ
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5W19
 | | Tryptophan indole-lyase complex with oxindolyl-L-alanine | | 分子名称: | 1-carboxy-1-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]azaniumyl}-2-[(3R)-2-oxo-2,3-dihydro-1H-indol-3-yl]ethan-1-ide, POTASSIUM ION, Tryptophanase | | 著者 | Phillips, R.S, Wood, Z.A. | | 登録日 | 2017-06-02 | | 公開日 | 2018-06-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The crystal structure of Proteus vulgaris tryptophan indole-lyase complexed with oxindolyl-L-alanine: implications for the reaction mechanism.
Acta Crystallogr D Struct Biol, 74, 2018
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5TGL
 | | A MODEL FOR INTERFACIAL ACTIVATION IN LIPASES FROM THE STRUCTURE OF A FUNGAL LIPASE-INHIBITOR COMPLEX | | 分子名称: | LIPASE, N-HEXYLPHOSPHONATE ETHYL ESTER | | 著者 | Brzozowski, A.M, Derewenda, U, Derewenda, Z.S, Dodson, G.G, Lawson, D, Turkenburg, J.P, Bjorkling, F, Huge-Jensen, B, Patkar, S.R, Thim, L. | | 登録日 | 1991-10-30 | | 公開日 | 1994-01-31 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | A model for interfacial activation in lipases from the structure of a fungal lipase-inhibitor complex.
Nature, 351, 1991
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1TGL
 | | A SERINE PROTEASE TRIAD FORMS THE CATALYTIC CENTRE OF A TRIACYLGLYCEROL LIPASE | | 分子名称: | TRIACYL-GLYCEROL ACYLHYDROLASE | | 著者 | Brady, L, Brzozowski, A.M, Derewenda, Z.S, Dodson, E.J, Dodson, G.G, Tolley, S.P, Turkenburg, J.P, Christiansen, L, Huge-Jensen, B, Norskov, L, Thim, L. | | 登録日 | 1990-02-05 | | 公開日 | 1990-10-15 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | A serine protease triad forms the catalytic centre of a triacylglycerol lipase.
Nature, 343, 1990
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1EV3
 | | Structure of the rhombohedral form of the M-cresol/insulin R6 hexamer | | 分子名称: | CHLORIDE ION, INSULIN, M-CRESOL, ... | | 著者 | Smith, G.D, Ciszak, E, Magrum, L.A, Pangborn, W.A, Blessing, R.H. | | 登録日 | 2000-04-19 | | 公開日 | 2000-12-04 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | R6 hexameric insulin complexed with m-cresol or resorcinol.
Acta Crystallogr.,Sect.D, 56, 2000
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1EV6
 | | Structure of the monoclinic form of the M-cresol/insulin R6 hexamer | | 分子名称: | CHLORIDE ION, INSULIN, M-CRESOL, ... | | 著者 | Smith, G.D, Ciszak, E, Magrum, L.A, Pangborn, W.A, Blessing, R.H. | | 登録日 | 2000-04-19 | | 公開日 | 2000-12-04 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | R6 Hexameric Insulin Complexed with m-Cresol or Resorcinol
Biochem.Biophys.Res.Commun., 56, 2000
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1EVR
 | | The structure of the resorcinol/insulin R6 hexamer | | 分子名称: | CHLORIDE ION, INSULIN, RESORCINOL, ... | | 著者 | Smith, G.D, Ciszak, E, Magrum, L.A, Pangborn, W.A, Blessing, R.H. | | 登録日 | 2000-04-20 | | 公開日 | 2000-12-04 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | R6 hexameric insulin complexed with m-cresol or resorcinol.
Acta Crystallogr.,Sect.D, 56, 2000
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4TGL
 | | CATALYSIS AT THE INTERFACE: THE ANATOMY OF A CONFORMATIONAL CHANGE IN A TRIGLYCERIDE LIPASE | | 分子名称: | DIETHYL PHOSPHONATE, TRIACYL-GLYCEROL ACYLHYDROLASE | | 著者 | Derewenda, U, Brzozowski, A.M, Lawson, D, Derewenda, Z.S. | | 登録日 | 1991-07-29 | | 公開日 | 1993-07-15 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Catalysis at the interface: the anatomy of a conformational change in a triglyceride lipase.
Biochemistry, 31, 1992
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3W7Z
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1YCB
 | | DISTAL POCKET POLARITY IN LIGAND BINDING TO MYOGLOBIN: DEOXY AND CARBONMONOXY FORMS OF A THREONINE68 (E11) MUTANT INVESTIGATED BY X-RAY CRYSTALLOGRAPHY AND INFRARED SPECTROSCOPY | | 分子名称: | MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Cameron, A.D, Smerdon, S.J, Wilkinson, A.J, Habash, J, Helliwell, J.R. | | 登録日 | 1993-08-10 | | 公開日 | 1994-01-31 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Distal pocket polarity in ligand binding to myoglobin: deoxy and carbonmonoxy forms of a threonine68(E11) mutant investigated by X-ray crystallography and infrared spectroscopy.
Biochemistry, 32, 1993
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1MYI
 | | HIGH RESOLUTION X-RAY STRUCTURES OF PIG METMYOGLOBIN AND TWO CD3 MUTANTS MB(LYS45-> ARG) AND MB(LYS45-> SER) | | 分子名称: | MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Smerdon, S.J, Oldfield, T.J, Wilkinson, A.J, Dauter, Z, Petratos, K, Wilson, K.S. | | 登録日 | 1992-02-27 | | 公開日 | 1994-01-31 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | High-resolution X-ray structures of pig metmyoglobin and two CD3 mutants: Mb(Lys45----Arg) and Mb(Lys45----Ser).
Biochemistry, 31, 1992
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1YCA
 | | DISTAL POCKET POLARITY IN LIGAND BINDING TO MYOGLOBIN: DEOXY AND CARBONMONOXY FORMS OF A THREONINE68 (E11) MUTANT INVESTIGATED BY X-RAY CRYSTALLOGRAPHY AND INFRARED SPECTROSCOPY | | 分子名称: | CARBON MONOXIDE, MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Cameron, A.D, Smerdon, S.J, Wilkinson, A.J, Habash, J, Helliwell, J.R. | | 登録日 | 1993-08-10 | | 公開日 | 1994-01-31 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Distal pocket polarity in ligand binding to myoglobin: deoxy and carbonmonoxy forms of a threonine68(E11) mutant investigated by X-ray crystallography and infrared spectroscopy.
Biochemistry, 32, 1993
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1RKM
 | | STRUCTURE OF OPPA | | 分子名称: | OLIGO-PEPTIDE BINDING PROTEIN | | 著者 | Sleigh, S.H, Tame, J.R.H, Wilkinson, A.J. | | 登録日 | 1997-03-25 | | 公開日 | 1997-07-29 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Peptide binding in OppA, the crystal structures of the periplasmic oligopeptide binding protein in the unliganded form and in complex with lysyllysine.
Biochemistry, 36, 1997
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2AAA
 | | CALCIUM BINDING IN ALPHA-AMYLASES: AN X-RAY DIFFRACTION STUDY AT 2.1 ANGSTROMS RESOLUTION OF TWO ENZYMES FROM ASPERGILLUS | | 分子名称: | ALPHA-AMYLASE, CALCIUM ION | | 著者 | Brady, L, Brzozowski, A.M, Derewenda, Z, Dodson, E.J, Dodson, G.G. | | 登録日 | 1991-02-27 | | 公開日 | 1993-07-15 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | | 主引用文献 | Calcium binding in alpha-amylases: an X-ray diffraction study at 2.1-A resolution of two enzymes from Aspergillus.
Biochemistry, 29, 1990
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