3CF0
 
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3CF3
 | | Structure of P97/vcp in complex with ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | | 著者 | Davies, J.M, Delabarre, B, Brunger, A.T, Weis, W.I. | | 登録日 | 2008-03-01 | | 公開日 | 2008-04-22 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (4.25 Å) | | 主引用文献 | Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change.
Structure, 16, 2008
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5CCH
 | | Structure of the Ca2+-bound synaptotagmin-1 SNARE complex (short unit cell form) | | 分子名称: | CALCIUM ION, Synaptosomal-associated protein 25, Synaptotagmin-1, ... | | 著者 | Zhou, Q, Zhao, M, Lyubimov, A.Y, Uervirojnangkoorn, M, Zeldin, O.B, Weis, W.I, Brunger, A.T. | | 登録日 | 2015-07-02 | | 公開日 | 2015-08-12 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.
Nature, 525, 2015
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5C1M
 | | Crystal structure of active mu-opioid receptor bound to the agonist BU72 | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2R,3S,3aR,5aR,6R,11bR,11cS)-3a-methoxy-3,14-dimethyl-2-phenyl-2,3,3a,6,7,11c-hexahydro-1H-6,11b-(epiminoethano)-3,5a-methanonaphtho[2,1-g]indol-10-ol, CHOLESTEROL, ... | | 著者 | Huang, W.J, Manglik, A, Venkatakrishnan, A.J, Laeremans, T, Feinberg, E.N, Sanborn, A.L, Kato, H.E, Livingston, K.E, Thorsen, T.S, Kling, R, Granier, S, Gmeiner, P, Husbands, S.M, Traynor, J.R, Weis, W.I, Steyaert, J, Dror, R.O, Kobilka, B.K. | | 登録日 | 2015-06-15 | | 公開日 | 2015-08-05 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | Structural insights into mu-opioid receptor activation.
Nature, 524, 2015
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5CCG
 | | Structure of the Ca2+-bound synaptotagmin-1 SNARE complex (long unit cell form) | | 分子名称: | CALCIUM ION, Synaptosomal-associated protein 25, Synaptotagmin-1, ... | | 著者 | Zhou, Q, Zhao, M, Lyubimov, A.Y, Uervirojnangkoorn, M, Zeldin, O.B, Weis, W.I, Brunger, A.T. | | 登録日 | 2015-07-02 | | 公開日 | 2015-08-12 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.
Nature, 525, 2015
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5DZZ
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5CCI
 | | Structure of the Mg2+-bound synaptotagmin-1 SNARE complex (short unit cell form) | | 分子名称: | MAGNESIUM ION, Synaptosomal-associated protein 25, Synaptotagmin-1, ... | | 著者 | Zhou, Q, Zhao, M, Lyubimov, A.Y, Uervirojnangkoorn, M, Weis, W.I, Brunger, A.T. | | 登録日 | 2015-07-02 | | 公開日 | 2015-08-12 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (4.1 Å) | | 主引用文献 | Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.
Nature, 525, 2015
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4KMB
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1T08
 | | Crystal structure of beta-catenin/ICAT helical domain/unphosphorylated APC R3 | | 分子名称: | Adenomatous polyposis coli protein, Beta-catenin, Beta-catenin-interacting protein 1 | | 著者 | Ha, N.-C, Tonozuka, T, Stamos, J.L, Weis, W.I. | | 登録日 | 2004-04-07 | | 公開日 | 2004-10-12 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation
Mol.Cell, 15, 2004
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1V18
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1SL5
 | | Crystal Structure of DC-SIGN carbohydrate recognition domain complexed with LNFP III (Dextra L504). | | 分子名称: | CALCIUM ION, MAGNESIUM ION, alpha-L-fucopyranose-(1-3)-[beta-D-galactopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose, ... | | 著者 | Guo, Y, Feinberg, H, Conroy, E, Mitchell, D.A, Alvarez, R, Blixt, O, Taylor, M.E, Weis, W.I, Drickamer, K. | | 登録日 | 2004-03-05 | | 公開日 | 2004-06-15 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural basis for distinct ligand-binding and targeting properties of the receptors
DC-SIGN and DC-SIGNR
Nat.Struct.Mol.Biol., 11, 2004
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1SL4
 | | Crystal Structure of DC-SIGN carbohydrate recognition domain complexed with Man4 | | 分子名称: | CALCIUM ION, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose, mDC-SIGN1B type I isoform | | 著者 | Guo, Y, Feinberg, H, Conroy, E, Mitchell, D.A, Alvarez, R, Blixt, O, Taylor, M.E, Weis, W.I, Drickamer, K. | | 登録日 | 2004-03-05 | | 公開日 | 2004-06-15 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Structural basis for distinct ligand-binding and targeting properties of the receptors
DC-SIGN and DC-SIGNR
Nat.Struct.Mol.Biol., 11, 2004
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1SL6
 | | Crystal Structure of a fragment of DC-SIGNR (containg the carbohydrate recognition domain and two repeats of the neck) complexed with Lewis-x. | | 分子名称: | C-type lectin DC-SIGNR, CALCIUM ION, alpha-L-fucopyranose-(1-3)-[beta-D-galactopyranose-(1-4)]2-acetamido-2-deoxy-alpha-D-glucopyranose | | 著者 | Guo, Y, Feinberg, H, Conroy, E, Mitchell, D.A, Alvarez, R, Blixt, O, Taylor, M.E, Weis, W.I, Drickamer, K. | | 登録日 | 2004-03-05 | | 公開日 | 2004-06-15 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structural basis for distinct ligand-binding and targeting properties of the receptors
DC-SIGN and DC-SIGNR
Nat.Struct.Mol.Biol., 11, 2004
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3PDS
 | | Irreversible Agonist-Beta2 Adrenoceptor Complex | | 分子名称: | 8-hydroxy-5-[(1R)-1-hydroxy-2-({2-[3-methoxy-4-(3-sulfanylpropoxy)phenyl]ethyl}amino)ethyl]quinolin-2(1H)-one, CHOLESTEROL, Fusion protein Beta-2 adrenergic receptor/Lysozyme, ... | | 著者 | Rosenbaum, D.M, Zhang, C, Lyons, J.A, Holl, R, Aragao, D, Arlow, D.H, Rasmussen, S.G.F, Choi, H.-J, DeVree, B.T, Sunahara, R.K, Chae, P.S, Gellman, S.H, Dror, R.O, Shaw, D.E, Weis, W.I, Caffrey, M, Gmeiner, P, Kobilka, B.K. | | 登録日 | 2010-10-24 | | 公開日 | 2011-01-12 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Structure and function of an irreversible agonist-beta(2) adrenoceptor complex
Nature, 469, 2011
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3R6N
 | | Crystal structure of a rigid four spectrin repeat fragment of the human desmoplakin plakin domain | | 分子名称: | (4S,5S)-1,2-DITHIANE-4,5-DIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Desmoplakin | | 著者 | Choi, H.-J, Weis, W.I. | | 登録日 | 2011-03-22 | | 公開日 | 2011-05-11 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Crystal structure of a rigid four-spectrin-repeat fragment of the human desmoplakin plakin domain.
J.Mol.Biol., 409, 2011
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3SN6
 | | Crystal structure of the beta2 adrenergic receptor-Gs protein complex | | 分子名称: | 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, Camelid antibody VHH fragment, Endolysin,Beta-2 adrenergic receptor, ... | | 著者 | Rasmussen, S.G.F, DeVree, B.T, Zou, Y, Kruse, A.C, Chung, K.Y, Kobilka, T.S, Thian, F.S, Chae, P.S, Pardon, E, Calinski, D, Mathiesen, J.M, Shah, S.T.A, Lyons, J.A, Caffrey, M, Gellman, S.H, Steyaert, J, Skiniotis, G, Weis, W.I, Sunahara, R.K, Kobilka, B.K. | | 登録日 | 2011-06-28 | | 公開日 | 2011-07-20 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Crystal structure of the beta2 adrenergic receptor-Gs protein complex
Nature, 477, 2011
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3S2K
 | | Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6. | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Ahn, V.E, Chu, M.L.-H, Choi, H.-J, Tran, D, Abo, A, Weis, W.I. | | 登録日 | 2011-05-16 | | 公開日 | 2011-11-02 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6.
Dev.Cell, 21, 2011
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4NU1
 | | Crystal structure of a transition state mimic of the GSK-3/Axin complex bound to phosphorylated N-terminal auto-inhibitory pS9 peptide | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Axin-1, ... | | 著者 | Chu, M.L.-H, Stamos, J.L, Enos, M.D, Shah, N, Weis, W.I. | | 登録日 | 2013-12-03 | | 公開日 | 2014-03-26 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6.
Elife, 3, 2014
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4NM5
 | | Crystal structure of GSK-3/Axin complex bound to phosphorylated Wnt receptor LRP6 c-motif | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Axin-1, CHLORIDE ION, ... | | 著者 | Stamos, J.L, Chu, M.L.-H, Enos, M.D, Shah, N, Weis, W.I. | | 登録日 | 2013-11-14 | | 公開日 | 2014-03-26 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6.
Elife, 3, 2014
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4ONS
 | | Structural and thermodynamic characterization of cadherin-beta-catenin-alpha-catenin complex formation | | 分子名称: | Catenin alpha-2, Catenin beta-1 | | 著者 | Pokutta, S, Choi, H.-J, Ahlsen, G, Hansen, S.D, Weis, W.I. | | 登録日 | 2014-01-29 | | 公開日 | 2014-04-09 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural and Thermodynamic Characterization of Cadherin beta-Catenin alpha-Catenin Complex Formation.
J.Biol.Chem., 289, 2014
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2M4N
 | | Solution structure of the putative Ras interaction domain of AFD-1, isoform a from Caenorhabditis elegans | | 分子名称: | Protein AFD-1, isoform a | | 著者 | Harris, R, Hillerich, B, Ahmed, M, Bonanno, J.B, Chamala, S, Evans, B, Lafleur, J, Hammonds, J, Washington, E, Stead, M, Love, J, Attonito, J, Seidel, R.D, Liddington, R.C, Weis, W.I, Nelson, W.J, Girvin, M.E, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Assembly, Dynamics and Evolution of Cell-Cell and Cell-Matrix Adhesions (CELLMAT) | | 登録日 | 2013-02-07 | | 公開日 | 2013-03-20 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the putative Ras interaction domain of AFD-1, isoform a from Caenorhabditis elegans
To be Published
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2OAJ
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4OM2
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4ONG
 | | Fab fragment of 3D6 in complex with amyloid beta 1-40 | | 分子名称: | 3D6 FAB ANTIBODY HEAVY CHAIN, 3D6 FAB ANTIBODY LIGHT CHAIN, Amyloid beta A4 protein, ... | | 著者 | Feinberg, H, Saldanha, J.W, Diep, L, Goel, A, Widom, A, Veldman, G.M, Weis, W.I, Schenk, D, Basi, G.S. | | 登録日 | 2014-01-28 | | 公開日 | 2014-06-11 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure reveals conservation of amyloid-beta conformation recognized by 3D6 following humanization to bapineuzumab.
Alzheimers Res Ther, 6, 2014
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4ONF
 | | Fab fragment of 3D6 in complex with amyloid beta 1-7 | | 分子名称: | 3D6 FAB ANTIBODY HEAVY CHAIN, 3D6 FAB ANTIBODY LIGHT CHAIN, Amyloid beta A4 protein | | 著者 | Feinberg, H, Saldanha, J.W, Diep, L, Goel, A, Widom, A, Veldman, G.M, Weis, W.I, Schenk, D, Basi, G.S. | | 登録日 | 2014-01-28 | | 公開日 | 2014-06-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure reveals conservation of amyloid-beta conformation recognized by 3D6 following humanization to bapineuzumab.
Alzheimers Res Ther, 6, 2014
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