3JC6
| Structure of the eukaryotic replicative CMG helicase and pumpjack motion | 分子名称: | Cell division control protein 45, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ... | 著者 | Li, H, Bai, L, Yuan, Z, Sun, J, Georgescu, R.E, Liu, J, O'Donnell, M.E. | 登録日 | 2015-11-24 | 公開日 | 2016-02-10 | 最終更新日 | 2018-07-18 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation. Nat.Struct.Mol.Biol., 23, 2016
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3JC7
| Structure of the eukaryotic replicative CMG helicase and pumpjack motion | 分子名称: | Cell division control protein 45, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ... | 著者 | Li, H, Bai, L, Yuan, Z, Sun, J, Georgescu, R.E, Liu, J, O'Donnell, M.E. | 登録日 | 2015-11-24 | 公開日 | 2016-02-10 | 最終更新日 | 2018-07-18 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation. Nat.Struct.Mol.Biol., 23, 2016
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8U86
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8U7L
| Cryo-EM structure of LRRK2 bound to type II inhibitor GZD824 | 分子名称: | 4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-[(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide, GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2 | 著者 | Zhu, H, Sun, J. | 登録日 | 2023-09-15 | 公開日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Pharmacology of LRRK2 with type I and II kinase inhibitors revealed by cryo-EM. Cell Discov, 10, 2024
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8U8A
| Cryo-EM structure of LRRK2 bound to type II inhibitor ponatinib | 分子名称: | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2 | 著者 | Zhu, H, Sun, J. | 登録日 | 2023-09-16 | 公開日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Pharmacology of LRRK2 with type I and II kinase inhibitors revealed by cryo-EM. Cell Discov, 10, 2024
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8U8B
| Cryo-EM structure of LRRK2 bound to type II inhibitor rebastinib | 分子名称: | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide, GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2 | 著者 | Zhu, H, Sun, J. | 登録日 | 2023-09-16 | 公開日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Pharmacology of LRRK2 with type I and II kinase inhibitors revealed by cryo-EM. Cell Discov, 10, 2024
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3JC5
| Structure of the eukaryotic replicative CMG helicase and pumpjack motion | 分子名称: | Cell division control protein 45, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ... | 著者 | Li, H, Bai, L, Yuan, Z, Sun, J, Georgescu, R.E, Liu, J, O'Donnell, M.E. | 登録日 | 2015-11-24 | 公開日 | 2016-02-10 | 最終更新日 | 2018-07-18 | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | 主引用文献 | Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation. Nat.Struct.Mol.Biol., 23, 2016
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7BW7
| Cryo-EM Structure for the Ectodomain of the Full-length Human Insulin Receptor in Complex with 1 Insulin. | 分子名称: | Insulin fusion, Insulin receptor | 著者 | Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T. | 登録日 | 2020-04-13 | 公開日 | 2021-04-14 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor To Be Published
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7BW8
| Cryo-EM Structure for the Insulin Binding Region in the Ectodomain of the Full-length Human Insulin Receptor in Complex with 1 Insulin | 分子名称: | Insulin fusion, Insulin receptor | 著者 | Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T. | 登録日 | 2020-04-14 | 公開日 | 2021-04-14 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor To Be Published
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7BWA
| Cryo-EM Structure for the Ectodomain of the Full-length Human Insulin Receptor in Complex with 2 Insulin | 分子名称: | Insulin fusion, Insulin receptor | 著者 | Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T. | 登録日 | 2020-04-14 | 公開日 | 2021-04-14 | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | 主引用文献 | Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor To Be Published
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3MHZ
| 1.7A structure of 2-fluorohistidine labeled Protective Antigen | 分子名称: | CALCIUM ION, Protective antigen, TETRAETHYLENE GLYCOL | 著者 | Lovell, S, Battaile, K.P, Wimalasena, D.S, Janowiak, B.E, Miyagi, M, Sun, J, Hajduch, J, Pooput, C, Kirk, K.L, Bann, J.G. | 登録日 | 2010-04-09 | 公開日 | 2010-08-11 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Evidence that histidine protonation of receptor-bound anthrax protective antigen is a trigger for pore formation. Biochemistry, 49, 2010
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5B60
| Crystal structure of PtLCIB4 S47R mutant, a homolog of the limiting CO2-inducible protein LCIB | 分子名称: | CHLORIDE ION, PtLCIB4 S47R mutant, ZINC ION | 著者 | Jin, S, Sun, J, Wunder, T, Tang, D, Mueller-Caja, O.M, Gao, Y. | 登録日 | 2016-05-24 | 公開日 | 2016-12-07 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural insights into the LCIB protein family reveals a new group of beta-carbonic anhydrases Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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5B5Y
| Crystal structure of PtLCIB4, a homolog of the limiting CO2-inducible protein LCIB | 分子名称: | ACETATE ION, PtLCIB4, ZINC ION | 著者 | Jin, S, Sun, J, Wunder, T, Tang, D, Mueller-Cajar, O.M, Gao, Y. | 登録日 | 2016-05-24 | 公開日 | 2016-12-07 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural insights into the LCIB protein family reveals a new group of beta-carbonic anhydrases Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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5B5Z
| Crystal structure of PtLCIB4 H88A mutant, a homolog of the limiting CO2-inducible protein LCIB | 分子名称: | PtLCIB4 H88A mutant, ZINC ION | 著者 | Jin, S, Sun, J, Wunder, T, Tang, D, Mueller-Caja, O.M, Gao, Y. | 登録日 | 2016-05-24 | 公開日 | 2016-12-07 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural insights into the LCIB protein family reveals a new group of beta-carbonic anhydrases Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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5B5X
| Crystal structure of limiting CO2-inducible protein LCIC | 分子名称: | SULFATE ION, ZINC ION, limiting CO2-inducible protein LCIC | 著者 | Jin, S, Sun, J, Wunder, T, Tang, D, Mueller-Cajar, O.M, Gao, Y. | 登録日 | 2016-05-24 | 公開日 | 2016-12-07 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.511 Å) | 主引用文献 | Structural insights into the LCIB protein family reveals a new group of beta-carbonic anhydrases Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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4ZUZ
| SidC 1-871 | 分子名称: | SidC | 著者 | Luo, X, Wasilko, D.J, Liu, Y, Sun, J, Wu, X, Luo, Z.-Q, Mao, Y. | 登録日 | 2015-05-18 | 公開日 | 2015-07-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | 主引用文献 | Structure of the Legionella Virulence Factor, SidC Reveals a Unique PI(4)P-Specific Binding Domain Essential for Its Targeting to the Bacterial Phagosome. Plos Pathog., 11, 2015
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6A67
| Crystal structure of influenza A virus H5 hemagglutinin globular head in complex with the Fab of antibody FLD21.140 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FLD21.140 Heavy Chain, FLD21.140 Light Chain, ... | 著者 | Wang, P, Zuo, Y, Sun, J, Zhang, L, Wang, X. | 登録日 | 2018-06-26 | 公開日 | 2018-08-29 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Complementary recognition of the receptor-binding site of highly pathogenic H5N1 influenza viruses by two human neutralizing antibodies. J. Biol. Chem., 293, 2018
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6IUT
| Crystal structure of influenza A virus H5 hemagglutinin globular head in complex with the Fab of antibody AVFluIgG01 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, AVFluIgG01 Heavy Chain, ... | 著者 | Wang, P, Zuo, Y, Sun, J, Zhang, L, Wang, X. | 登録日 | 2018-11-30 | 公開日 | 2019-01-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural and functional definition of a vulnerable site on the hemagglutinin of highly pathogenic avian influenza A virus H5N1. J. Biol. Chem., 294, 2019
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6IUV
| Crystal structure of influenza A virus H5 hemagglutinin globular head in complex with the Fab of antibody 3C11 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 3C11 Heavy Chain, 3C11 Light Chain, ... | 著者 | Wang, P, Zuo, Y, Sun, J, Zhang, L, Wang, X. | 登録日 | 2018-11-30 | 公開日 | 2019-01-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.332 Å) | 主引用文献 | Structural and functional definition of a vulnerable site on the hemagglutinin of highly pathogenic avian influenza A virus H5N1. J. Biol. Chem., 294, 2019
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2CAZ
| ESCRT-I core | 分子名称: | PROTEIN SRN2, SUPPRESSOR PROTEIN STP22 OF TEMPERATURE-SENSITIVE ALPHA-FACTOR RECEPTOR AND ARGININE PERMEASE, VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS28 | 著者 | Gill, D.J, Teo, H, Sun, J, Perisic, O, Veprintsev, D.B, Vallis, Y, Emr, S.D, Williams, R.L. | 登録日 | 2005-12-23 | 公開日 | 2006-04-07 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Escrt-I Core and Escrt-II Glue Domain Structures Reveal Role for Glue in Linking to Escrt-I and Membranes. Cell(Cambridge,Mass.), 125, 2006
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2FDP
| Crystal structure of beta-secretase complexed with an amino-ethylene inhibitor | 分子名称: | Beta-secretase 1, N1-((2S,3S,5R)-3-AMINO-6-(4-FLUOROPHENYLAMINO)-5-METHYL-6-OXO-1-PHENYLHEXAN-2-YL)-N3,N3-DIPROPYLISOPHTHALAMIDE | 著者 | Yang, W, Lu, W, Lu, Y, Zhong, M, Sun, J, Thomas, A.E, Wilkinson, J.M, Fucini, R.V, Lam, M, Randal, M, Shi, X.P, Jacobs, J.W, McDowell, R.S, Gordon, E.M, Ballinger, M.D. | 登録日 | 2005-12-14 | 公開日 | 2006-01-24 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1. J.Med.Chem., 49, 2006
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4GKF
| Crystal structure and characterization of Cmr5 protein from Pyrococcus furiosus | 分子名称: | CRISPR system Cmr subunit Cmr5 | 著者 | Park, J, Sun, J, Park, S, Hwang, H, Park, M, Shin, M.S. | 登録日 | 2012-08-11 | 公開日 | 2013-01-23 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of Cmr5 from Pyrococcus furiosus and its functional implications Febs Lett., 587, 2013
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3OX4
| Structures of iron-dependent alcohol dehydrogenase 2 from Zymomonas mobilis ZM4 complexed with NAD cofactor | 分子名称: | Alcohol dehydrogenase 2, FE (II) ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Moon, J.H, Lee, H.J, Song, J.M, Park, S.Y, Park, M.Y, Park, H.M, Sun, J, Park, J.H, Kim, J.S. | 登録日 | 2010-09-21 | 公開日 | 2011-02-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structures of iron-dependent alcohol dehydrogenase 2 from Zymomonas mobilis ZM4 with and without NAD+ cofactor J.Mol.Biol., 407, 2011
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3OWO
| Structures of iron-dependent alcohol dehydrogenase 2 from Zymomonas mobilis ZM4 with and without NAD cofactor | 分子名称: | Alcohol dehydrogenase 2, FE (II) ION | 著者 | Moon, J.H, Lee, H.J, Song, J.M, Park, S.Y, Park, M.Y, Park, H.M, Sun, J, Park, J.H, Kim, J.S. | 登録日 | 2010-09-20 | 公開日 | 2011-02-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Structures of iron-dependent alcohol dehydrogenase 2 from Zymomonas mobilis ZM4 with and without NAD+ cofactor J.Mol.Biol., 407, 2011
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2J9V
| 2 Angstrom X-ray structure of the yeast ESCRT-I Vps28 C-terminus | 分子名称: | VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 | 著者 | Gill, D.J, Teo, H.L, Sun, J, Perisic, O, Veprintsev, D.B, Emr, S.D, Williams, R.L. | 登録日 | 2006-11-16 | 公開日 | 2007-01-23 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Insight Into the Escrt-I/-II Link and its Role in Mvb Trafficking. Embo J., 26, 2007
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