6MN0
| Crystal structure of meta-AAC0038, an environmental aminoglycoside resistance enzyme, H168A mutant in complex with acetyl-CoA | 分子名称: | 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL, ACETYL COENZYME *A, Aminoglycoside N(3)-acetyltransferase, ... | 著者 | Stogios, P.J, Skarina, T, Zu, X, Yim, V, Savchenko, A, Joachimiak, A, Satchell, K.J, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2018-10-01 | 公開日 | 2018-10-24 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family. Commun Biol, 5, 2022
|
|
2I2W
| Crystal Structure of Escherichia Coli Phosphoheptose Isomerase | 分子名称: | GLYCEROL, Phosphoheptose isomerase | 著者 | DeLeon, G, Blakely, K, Zhang, K, Wright, G, Junop, M. | 登録日 | 2006-08-17 | 公開日 | 2007-08-21 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structure and Function of Sedoheptulose-7-phosphate Isomerase, a Critical Enzyme for Lipopolysaccharide Biosynthesis and a Target for Antibiotic Adjuvants J.Biol.Chem., 283, 2008
|
|
2I22
| Crystal structure of Escherichia coli phosphoheptose isomerase in complex with reaction substrate sedoheptulose 7-phosphate | 分子名称: | D-ALTRO-HEPT-2-ULOSE 7-PHOSPHATE, Phosphoheptose isomerase | 著者 | Blakely, K, Zhang, K, DeLeon, G, Wright, G, Junop, M. | 登録日 | 2006-08-15 | 公開日 | 2007-08-21 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure and Function of Sedoheptulose-7-phosphate Isomerase, a Critical Enzyme for Lipopolysaccharide Biosynthesis and a Target for Antibiotic Adjuvants J.Biol.Chem., 283, 2008
|
|
2OV8
| |
2OVB
| Crystal Structure of StaL-sulfate complex | 分子名称: | SULFATE ION, StaL | 著者 | Shi, R, Matte, A, Cygler, M, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | 登録日 | 2007-02-13 | 公開日 | 2007-02-27 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Crystal structure of StaL, a glycopeptide antibiotic sulfotransferase from Streptomyces toyocaensis. J.Biol.Chem., 282, 2007
|
|
2OVF
| Crystal Structure of StaL-PAP complex | 分子名称: | ADENOSINE-3'-5'-DIPHOSPHATE, StaL | 著者 | Shi, R, Matte, A, Cygler, M, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | 登録日 | 2007-02-13 | 公開日 | 2007-02-27 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Crystal structure of StaL, a glycopeptide antibiotic sulfotransferase from Streptomyces toyocaensis. J.Biol.Chem., 282, 2007
|
|
3ESQ
| |
3G2Q
| Crystal Structure of the Glycopeptide N-methyltransferase MtfA complexed with sinefungin | 分子名称: | PCZA361.24, SINEFUNGIN | 著者 | Shi, R, Matte, A, Cygler, M, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | 登録日 | 2009-01-31 | 公開日 | 2009-05-05 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Structure and function of the glycopeptide N-methyltransferase MtfA, a tool for the biosynthesis of modified glycopeptide antibiotics. Chem.Biol., 16, 2009
|
|
3G2P
| Crystal Structure of the Glycopeptide N-methyltransferase MtfA complexed with (S)-adenosyl-L-homocysteine (SAH) | 分子名称: | PCZA361.24, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Shi, R, Matte, A, Cygler, M, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | 登録日 | 2009-01-31 | 公開日 | 2009-05-05 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Structure and function of the glycopeptide N-methyltransferase MtfA, a tool for the biosynthesis of modified glycopeptide antibiotics. Chem.Biol., 16, 2009
|
|
3G2M
| |
3ESR
| Crystal Structure of D,D-heptose1.7-bisphosphate phosphatase from E. coli in complex with calcium and phosphate | 分子名称: | CALCIUM ION, D,D-heptose 1,7-bisphosphate phosphatase, PHOSPHATE ION, ... | 著者 | Sugiman-Marangos, S.N, Junop, M.S. | 登録日 | 2008-10-06 | 公開日 | 2008-10-14 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal Structure of D,D-heptose 1.7-bisphosphate phosphatase from E. Coli. To be Published
|
|
3G2O
| Crystal Structure of the Glycopeptide N-methyltransferase MtfA complexed with (S)-adenosyl-L-methionine (SAM) | 分子名称: | PCZA361.24, S-ADENOSYLMETHIONINE | 著者 | Shi, R, Matte, A, Cygler, M, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | 登録日 | 2009-01-31 | 公開日 | 2009-05-05 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure and function of the glycopeptide N-methyltransferase MtfA, a tool for the biosynthesis of modified glycopeptide antibiotics. Chem.Biol., 16, 2009
|
|
1X92
| CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA PHOSPHOHEPTOSE ISOMERASE IN COMPLEX WITH REACTION PRODUCT D-GLYCERO-D-MANNOPYRANOSE-7-PHOSPHATE | 分子名称: | 7-O-phosphono-D-glycero-alpha-D-manno-heptopyranose, PHOSPHOHEPTOSE ISOMERASE | 著者 | Walker, J.R, Evdokimova, E, Kudritska, M, Joachimiak, A, Edwards, A, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2004-08-19 | 公開日 | 2004-10-26 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants. J.Biol.Chem., 283, 2008
|
|
5FBT
| Crystal structure of rifampin phosphotransferase RPH-Lm from Listeria monocytogenes in complex with rifampin | 分子名称: | CHLORIDE ION, Phosphoenolpyruvate synthase, Rifampin | 著者 | Stogios, P.J, Wawrzak, Z, Skarina, T, Yim, V, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2015-12-14 | 公開日 | 2015-12-30 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.702 Å) | 主引用文献 | Rifampin phosphotransferase is an unusual antibiotic resistance kinase. Nat Commun, 7, 2016
|
|
2GQN
| |
5UXD
| Crystal structure of macrolide 2'-phosphotransferase MphH from Brachybacterium faecium in complex with azithromycin | 分子名称: | AZITHROMYCIN, CHLORIDE ION, Macrolide 2'-phosphotransferase MphH, ... | 著者 | Stogios, P.J, Skarina, T, Wawrzak, Z, Yim, V, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2017-02-22 | 公開日 | 2017-08-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The evolution of substrate discrimination in macrolide antibiotic resistance enzymes. Nat Commun, 9, 2018
|
|
5US1
| Crystal structure of aminoglycoside acetyltransferase AAC(2')-Ia in complex with N2'-acetylgentamicin C1A and coenzyme A | 分子名称: | (1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl 2-(acetylamino)-6-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranoside, ACETYL COENZYME *A, Aminoglycoside 2'-N-acetyltransferase, ... | 著者 | Stogios, P.J, Evdokimova, E, Xu, Z, Wawrzak, Z, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2017-02-13 | 公開日 | 2017-03-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes. ACS Infect Dis, 4, 2018
|
|
5UXB
| Crystal structure of macrolide 2'-phosphotransferase MphH from Brachybacterium faecium, apoenzyme | 分子名称: | CHLORIDE ION, Macrolide 2'-phosphotransferase MphH | 著者 | Stogios, P.J, Skarina, T, Yim, V, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2017-02-22 | 公開日 | 2017-07-26 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.794 Å) | 主引用文献 | The evolution of substrate discrimination in macrolide antibiotic resistance enzymes. Nat Commun, 9, 2018
|
|
5UXA
| Crystal structure of macrolide 2'-phosphotransferase MphB from Escherichia coli | 分子名称: | CALCIUM ION, Macrolide 2'-phosphotransferase II | 著者 | Stogios, P.J, Evdokimova, E, Egorova, O, Di Leo, R, Yim, V, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2017-02-22 | 公開日 | 2017-06-28 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | The evolution of substrate discrimination in macrolide antibiotic resistance enzymes. Nat Commun, 9, 2018
|
|
5UXC
| Crystal structure of macrolide 2'-phosphotransferase MphH from Brachybacterium faecium in complex with GDP | 分子名称: | AZITHROMYCIN, CHLORIDE ION, GLYCEROL, ... | 著者 | Stogios, P.J, Skarina, T, Wawrzak, Z, Yim, V, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2017-02-22 | 公開日 | 2017-08-16 | 最終更新日 | 2019-12-11 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | The evolution of substrate discrimination in macrolide antibiotic resistance enzymes. Nat Commun, 9, 2018
|
|
1B87
| |
6CFD
| ADEP4 bound to E. faecium ClpP | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ATP-dependent Clp protease proteolytic subunit, N-[(6aS,12S,15aS,17R,21R,23aS)-17,21-dimethyl-6,11,15,20,23-pentaoxooctadecahydro-2H,6H,11H,15H-pyrido[2,1-i]dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13]oxatetraazacyclohexadecin-12-yl]-3,5-difluoro-Nalpha-[(2E)-hept-2-enoyl]-L-phenylalaninamide | 著者 | Lee, R.E, Griffith, E.C. | 登録日 | 2018-02-14 | 公開日 | 2018-05-16 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | In VivoandIn VitroEffects of a ClpP-Activating Antibiotic against Vancomycin-Resistant Enterococci. Antimicrob. Agents Chemother., 62, 2018
|
|
1J7U
| Crystal Structure of 3',5"-Aminoglycoside Phosphotransferase Type IIIa AMPPNP Complex | 分子名称: | AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Burk, D.L, Hon, W.C, Leung, A.K.-W, Berghuis, A.M. | 登録日 | 2001-05-18 | 公開日 | 2001-08-08 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural analyses of nucleotide binding to an aminoglycoside phosphotransferase. Biochemistry, 40, 2001
|
|
1J7L
| Crystal Structure of 3',5"-Aminoglycoside Phosphotransferase Type IIIa ADP Complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE, MAGNESIUM ION | 著者 | Burk, D.L, Hon, W.C, Leung, A.K.-W, Berghuis, A.M. | 登録日 | 2001-05-17 | 公開日 | 2001-08-08 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural analyses of nucleotide binding to an aminoglycoside phosphotransferase. Biochemistry, 40, 2001
|
|
1J7I
| Crystal Structure of 3',5"-Aminoglycoside Phosphotransferase Type IIIa Apoenzyme | 分子名称: | AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE | 著者 | Burk, D.L, Hon, W.C, Leung, A.K.-W, Berghuis, A.M. | 登録日 | 2001-05-16 | 公開日 | 2001-08-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural analyses of nucleotide binding to an aminoglycoside phosphotransferase. Biochemistry, 40, 2001
|
|