6MN0

Crystal structure of meta-AAC0038, an environmental aminoglycoside resistance enzyme, H168A mutant in complex with acetyl-CoA

Summary for 6MN0

• Entry DOI: 10.2210/pdb6mn0/pdb
• Related: 5HT0
• Descriptor: Aminoglycoside N(3)-acetyltransferase, ACETYL COENZYME *A, CHLORIDE ION, ... (7 entities in total)
• Functional Keywords: antibiotic_nat family, acetyltransferase, aminoglycoside, antibiotic resistance, metagenome, soil, coenzyme a, gentamicin, csgid, transferase, center for structural genomics of infectious diseases, national institute of allergy and infectious diseases, niaid
• Biological source: uncultured bacterium
• Total number of polymer chains: 6
• Total formula weight: 184445.69

Authors

Stogios, P.J.,Skarina, T.,Zu, X.,Yim, V.,Savchenko, A.,Joachimiak, A.,Satchell, K.J.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2018-10-01, release date: 2018-10-24, Last modification date: 2023-10-11)

• Primary citation: Stogios, P.J.,Bordeleau, E.,Xu, Z.,Skarina, T.,Evdokimova, E.,Chou, S.,Diorio-Toth, L.,D'Souza, A.W.,Patel, S.,Dantas, G.,Wright, G.D.,Savchenko, A.; Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family.; Commun Biol, 5:263-263, 2022; PubMed: 35338238; DOI: 10.1038/s42003-022-03219-w

Experimental method

X-RAY DIFFRACTION (2.4 Å)