Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6MN0

Crystal structure of meta-AAC0038, an environmental aminoglycoside resistance enzyme, H168A mutant in complex with acetyl-CoA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008080	molecular_function	N-acetyltransferase activity
A	0046677	biological_process	response to antibiotic
B	0008080	molecular_function	N-acetyltransferase activity
B	0046677	biological_process	response to antibiotic
C	0008080	molecular_function	N-acetyltransferase activity
C	0046677	biological_process	response to antibiotic
D	0008080	molecular_function	N-acetyltransferase activity
D	0046677	biological_process	response to antibiotic
E	0008080	molecular_function	N-acetyltransferase activity
E	0046677	biological_process	response to antibiotic
F	0008080	molecular_function	N-acetyltransferase activity
F	0046677	biological_process	response to antibiotic

Functional Information from PDB Data

site_id	AC1
Number of Residues	32
Details	binding site for residue ACO A 301

Chain	Residue
A	HIS29
A	PHE97
A	ALA159
A	PRO160
A	THR163
A	THR165
A	HOH416
A	HOH436
A	HOH451
A	HOH453
A	HOH457
A	ALA30
A	HOH465
A	HOH483
A	HOH485
A	HOH507
A	HOH508
A	HOH515
A	HOH527
A	HOH539
A	HOH540
A	HOH544
A	ALA31
B	GLN66
B	ARG93
B	HOH474
A	LEU32
A	ARG33
A	PRO42
A	TYR62
A	ASN95
A	GLY96

site_id	AC2
Number of Residues	1
Details	binding site for residue CL A 302

Chain	Residue
A	ARG257

site_id	AC3
Number of Residues	6
Details	binding site for residue GOL A 303

Chain	Residue
A	TRP65
A	ARG72
A	GLY115
A	TYR184
A	HOH534
A	HOH567

site_id	AC4
Number of Residues	6
Details	binding site for residue SO4 A 304

Chain	Residue
A	GLY158
A	ALA159
A	LEU161
A	ARG231
A	SER238
A	HOH443

site_id	AC5
Number of Residues	1
Details	binding site for residue SO4 A 305

Chain	Residue
A	ARG197

site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 A 306

Chain	Residue
A	ALA133
A	LEU134
A	ASP135
A	ARG141

site_id	AC7
Number of Residues	7
Details	binding site for residue PE3 A 307

Chain	Residue
A	PRO86
A	ARG110
A	THR129
A	ALA130
A	HOH425
C	ASP135
C	GLU200

site_id	AC8
Number of Residues	3
Details	binding site for residue PE3 A 308

Chain	Residue
A	TRP258
A	THR261
A	HOH440

site_id	AC9
Number of Residues	4
Details	binding site for residue PE3 A 309

Chain	Residue
A	LEU224
A	ALA225
A	HOH478
A	HOH481

site_id	AD1
Number of Residues	29
Details	binding site for residue ACO B 301

Chain	Residue
A	GLN66
A	ARG93
B	HIS29
B	ALA30
B	ALA31
B	LEU32
B	ARG33
B	PRO42
B	ASN95
B	GLY96
B	PHE97
B	ALA159
B	PRO160
B	THR163
B	THR165
B	HOH412
B	HOH413
B	HOH433
B	HOH468
B	HOH475
B	HOH478
B	HOH489
B	HOH496
B	HOH499
B	HOH500
B	HOH511
B	HOH537
B	HOH632
B	HOH661

site_id	AD2
Number of Residues	4
Details	binding site for residue SO4 B 302

Chain	Residue
B	ALA133
B	LEU134
B	ASP135
B	ARG141

site_id	AD3
Number of Residues	2
Details	binding site for residue SO4 B 303

Chain	Residue
B	ARG257
B	ARG260

site_id	AD4
Number of Residues	5
Details	binding site for residue PE3 B 304

Chain	Residue
B	ASP191
B	HOH401
C	ARG257
C	TRP258
C	THR261

site_id	AD5
Number of Residues	5
Details	binding site for residue PE3 B 305

Chain	Residue
B	PRO86
B	ARG110
B	GLU126
B	THR129
D	GLU200

site_id	AD6
Number of Residues	30
Details	binding site for residue ACO C 301

Chain	Residue
C	HIS29
C	ALA30
C	ALA31
C	LEU32
C	ARG33
C	PRO42
C	TYR62
C	ASN95
C	GLY96
C	PHE97
C	ALA159
C	PRO160
C	ASP162
C	THR163
C	THR165
C	HOH415
C	HOH443
C	HOH447
C	HOH454
C	HOH468
C	HOH473
C	HOH477
C	HOH495
C	HOH521
C	HOH529
C	HOH568
C	HOH624
C	HOH660
F	GLN66
F	ARG93

site_id	AD7
Number of Residues	2
Details	binding site for residue CL C 302

Chain	Residue
C	SER9
F	HIS80

site_id	AD8
Number of Residues	3
Details	binding site for residue SO4 C 303

Chain	Residue
C	ARG197
C	HOH405
C	HOH592

site_id	AD9
Number of Residues	5
Details	binding site for residue SO4 C 304

Chain	Residue
C	ALA112
C	ALA130
C	ASP131
C	HOH420
C	HOH478

site_id	AE1
Number of Residues	1
Details	binding site for residue SO4 C 305

Chain	Residue
C	ARG228

site_id	AE2
Number of Residues	3
Details	binding site for residue SO4 C 306

Chain	Residue
C	LYS230
C	ARG231
C	HOH458

site_id	AE3
Number of Residues	8
Details	binding site for residue PE3 C 307

Chain	Residue
C	ARG183
C	HOH504
D	PRO177
D	TRP258
D	GLY259
D	THR261
D	ALA262
D	HOH565

site_id	AE4
Number of Residues	26
Details	binding site for residue ACO D 301

Chain	Residue
D	HIS29
D	ALA30
D	ALA31
D	LEU32
D	ARG33
D	PRO42
D	ASN95
D	GLY96
D	PHE97
D	ALA159
D	PRO160
D	ASP162
D	THR163
D	THR165
D	HOH428
D	HOH441
D	HOH448
D	HOH462
D	HOH470
D	HOH484
D	HOH503
D	HOH510
D	HOH534
D	HOH600
E	GLN66
E	ARG93

site_id	AE5
Number of Residues	3
Details	binding site for residue GOL D 302

Chain	Residue
D	GLU124
D	TRP127
D	HOH432

site_id	AE6
Number of Residues	7
Details	binding site for residue GOL D 303

Chain	Residue
B	HOH425
D	PRO140
D	ARG141
D	LYS146
D	GLU149
D	HOH406
D	HOH592

site_id	AE7
Number of Residues	7
Details	binding site for residue GOL D 304

Chain	Residue
D	ASP64
D	TRP65
D	GLY115
D	TYR184
D	HOH402
D	HOH426
D	HOH500

site_id	AE8
Number of Residues	3
Details	binding site for residue SO4 D 305

Chain	Residue
D	ASP131
D	HOH407
D	HOH456

site_id	AE9
Number of Residues	3
Details	binding site for residue SO4 D 306

Chain	Residue
D	ARG78
D	TRP196
D	HOH494

site_id	AF1
Number of Residues	30
Details	binding site for residue ACO E 301

Chain	Residue
D	GLN66
D	ARG93
E	HIS29
E	ALA30
E	ALA31
E	LEU32
E	ARG33
E	PRO42
E	TYR62
E	ASN95
E	GLY96
E	PHE97
E	ALA159
E	PRO160
E	THR163
E	THR165
E	HOH408
E	HOH412
E	HOH425
E	HOH430
E	HOH445
E	HOH451
E	HOH452
E	HOH480
E	HOH494
E	HOH502
E	HOH525
E	HOH535
E	HOH554
E	HOH604

site_id	AF2
Number of Residues	4
Details	binding site for residue GOL E 302

Chain	Residue
E	ARG110
E	THR129
E	ALA130
E	SO4303

site_id	AF3
Number of Residues	6
Details	binding site for residue SO4 E 303

Chain	Residue
E	ALA112
E	ALA130
E	ASP131
E	GOL302
E	HOH432
E	HOH457

site_id	AF4
Number of Residues	3
Details	binding site for residue SO4 E 304

Chain	Residue
E	ARG8
E	HOH424
E	HOH437

site_id	AF5
Number of Residues	2
Details	binding site for residue SO4 E 305

Chain	Residue
E	ARG197
E	SO4308

site_id	AF6
Number of Residues	4
Details	binding site for residue SO4 E 306

Chain	Residue
E	PRO140
E	ARG141
E	HOH477
E	HOH519

site_id	AF7
Number of Residues	3
Details	binding site for residue SO4 E 307

Chain	Residue
E	TRP254
E	ARG257
E	HOH402

site_id	AF8
Number of Residues	5
Details	binding site for residue SO4 E 308

Chain	Residue
E	ALA133
E	LEU134
E	ASP135
E	ARG141
E	SO4305

site_id	AF9
Number of Residues	5
Details	binding site for residue PE3 E 309

Chain	Residue
E	ASP64
E	ILE92
E	GLU201
E	HOH409
E	HOH518

site_id	AG1
Number of Residues	29
Details	binding site for residue ACO F 301

Chain	Residue
C	GLN66
C	ARG93
F	HIS29
F	ALA30
F	ALA31
F	LEU32
F	ARG33
F	PRO42
F	TYR62
F	ASN95
F	GLY96
F	PHE97
F	ALA159
F	PRO160
F	ASP162
F	THR163
F	THR165
F	HOH415
F	HOH417
F	HOH433
F	HOH436
F	HOH445
F	HOH449
F	HOH468
F	HOH494
F	HOH496
F	HOH499
F	HOH515
F	HOH543

site_id	AG2
Number of Residues	6
Details	binding site for residue SO4 F 303

Chain	Residue
F	ALA133
F	LEU134
F	ASP135
F	ARG141
F	HOH435
F	HOH455

site_id	AG3
Number of Residues	2
Details	binding site for residue SO4 F 304

Chain	Residue
F	ARG8
F	HOH427

site_id	AG4
Number of Residues	6
Details	binding site for residue SO4 F 305

Chain	Residue
F	ASP131
F	HIS132
F	HOH410
F	HOH458
F	HOH474
F	HOH492

site_id	AG5
Number of Residues	4
Details	binding site for residue SO4 F 306

Chain	Residue
D	SER3
F	ARG78
F	TRP196
F	HOH424

site_id	AG6
Number of Residues	2
Details	binding site for residue PE3 F 307

Chain	Residue
F	PRO55
F	ALA56

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)