5UXD

Crystal structure of macrolide 2'-phosphotransferase MphH from Brachybacterium faecium in complex with azithromycin

Summary for 5UXD

Entry DOI	10.2210/pdb5uxd/pdb
Related	5UXA 5UXB 5UXC
Descriptor	Macrolide 2'-phosphotransferase MphH, AZITHROMYCIN, SULFATE ION, ... (5 entities in total)
Functional Keywords	antibiotic resistance, macrolide, cave bacterium, phosphotransferase, kinase, alpha/beta protein, azithromycin, structural genomics, center for structural genomics of infectious diseases, csgid, national institute of allergy and infectious diseases, niaid, transferase-antibiotic complex, transferase/antibiotic
Biological source	Brachybacterium faecium (strain ATCC 43885 / DSM 4810 / NCIB 9860)
Total number of polymer chains	2
Total formula weight	67078.09
Authors	Stogios, P.J.,Skarina, T.,Wawrzak, Z.,Yim, V.,Savchenko, A.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2017-02-22, release date: 2017-08-23, Last modification date: 2023-10-04)
Primary citation	Pawlowski, A.C.,Stogios, P.J.,Koteva, K.,Skarina, T.,Evdokimova, E.,Savchenko, A.,Wright, G.D. The evolution of substrate discrimination in macrolide antibiotic resistance enzymes. Nat Commun, 9:112-112, 2018 Cited by PubMed: 29317655 DOI: 10.1038/s41467-017-02680-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation