5UXC

Crystal structure of macrolide 2'-phosphotransferase MphH from Brachybacterium faecium in complex with GDP

Summary for 5UXC

Entry DOI	10.2210/pdb5uxc/pdb
Related	5UXA 5UXB 5UXD
Descriptor	Predicted aminoglycoside phosphotransferase, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (10 entities in total)
Functional Keywords	antibiotic resistance, macrolide, cave bacterium, phosphotransferase, kinase, alpha/beta protein, azithromycin, structural genomics, center for structural genomics of infectious diseases, csgid, national institute of allergy and infectious diseases, niaid, transferase-antibiotic complex, transferase/antibiotic
Biological source	Brachybacterium faecium
Total number of polymer chains	1
Total formula weight	34951.27
Authors	Stogios, P.J.,Skarina, T.,Wawrzak, Z.,Yim, V.,Savchenko, A.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2017-02-22, release date: 2017-08-16, Last modification date: 2019-12-11)
Primary citation	Pawlowski, A.C.,Stogios, P.J.,Koteva, K.,Skarina, T.,Evdokimova, E.,Savchenko, A.,Wright, G.D. The evolution of substrate discrimination in macrolide antibiotic resistance enzymes. Nat Commun, 9:112-112, 2018 Cited by PubMed: 29317655 DOI: 10.1038/s41467-017-02680-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.72 Å)

Structure validation