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Complement factor B protease domain in complex with the reversible inhibitor ((2S,4S)-1-((5,7-dimethyl-1H-indol-4-yl)methyl)-4-methoxypiperidin-2-yl)methanol.
分子名称:	Complement factor B, SULFATE ION, ZINC ION, ...
著者	Adams, C.M, Sellner, H, Ehara, T, Mac Sweeney, A, Crowley, M, Anderson, K, Karki, R, Mainolfi, N, Valeur, E, Sirockin, F, Gerhartz, B, Erbel, P, Hughes, N, Smith, T.M, Cumin, F, Argikar, U, Mogi, M, Sedrani, R, Wiesmann, C, Jaffee, B, Maibaum, J, Flohr, S, Harrison, R, Eder, J.
登録日	2019-02-22
公開日	2019-03-27
最終更新日	2024-01-24
実験手法	X-RAY DIFFRACTION (1.77 Å)
主引用文献	Small-molecule factor B inhibitor for the treatment of complement-mediated diseases. Proc.Natl.Acad.Sci.USA, 116, 2019

3TL5

Discovery of GDC-0980: a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor for the Treatment of Cancer
分子名称:	(2S)-1-(4-{[2-(2-aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl}piperazin-1-yl)-2-hydroxypropan-1-one, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
著者	Murray, J.M, Wiesmann, C.
登録日	2011-08-29
公開日	2011-11-02
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2.788 Å)
主引用文献	Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer. J.Med.Chem., 54, 2011

1SHY

The Crystal Structure of HGF beta-chain in Complex with the Sema Domain of the Met Receptor.
分子名称:	Hepatocyte growth factor, Hepatocyte growth factor receptor
著者	Stamos, J, Wiesmann, C.
登録日	2004-02-26
公開日	2004-06-15
最終更新日	2024-04-03
実験手法	X-RAY DIFFRACTION (3.22 Å)
主引用文献	Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor. Embo J., 23, 2004

1TZH

Crystal Structure of the Fab YADS1 Complexed with h-VEGF
分子名称:	Fab YADS1 Heavy Chain, Fab YADS1 Light Chain, Vascular endothelial growth factor A
著者	Fellouse, F.A, Wiesmann, C, Sidhu, S.S.
登録日	2004-07-09
公開日	2004-08-31
最終更新日	2023-08-23
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Synthetic antibodies from a four-amino-acid code: A dominant role for tyrosine in antigen recognition Proc.Natl.Acad.Sci.USA, 101, 2004

1TZI

Crystal Structure of the Fab YADS2 Complexed with h-VEGF
分子名称:	Fab YADS2 Heavy Chain, Fab YADS2 Light Chain, Vascular endothelial growth factor A
著者	Fellouse, F.A, Wiesmann, C, Sidhu, S.S.
登録日	2004-07-10
公開日	2004-08-31
最終更新日	2023-08-23
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	Synthetic antibodies from a four-amino-acid code: A dominant role for tyrosine in antigen recognition Proc.Natl.Acad.Sci.USA, 101, 2004

3CBX

The Dvl2 PDZ Domain in Complex with the C1 Inhibitory Peptide
分子名称:	(4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Dishevelled-2
著者	Appleton, B.A, Wiesmann, C.
登録日	2008-02-23
公開日	2009-03-03
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Inhibition of Wnt signaling by Dishevelled PDZ peptides Nat.Chem.Biol., 5, 2009

3CBY

The Dvl2 PDZ Domain in Complex with the N1 Inhibitory Peptide
分子名称:	1,2-ETHANEDIOL, Dishevelled-2
著者	Appleton, B.A, Wiesmann, C.
登録日	2008-02-23
公開日	2009-03-03
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (1.5 Å)
主引用文献	Inhibition of Wnt signaling by Dishevelled PDZ peptides Nat.Chem.Biol., 5, 2009

3CBZ

The Dvl2 PDZ Domain in Complex with the N2 Inhibitory Peptide
分子名称:	1,2-ETHANEDIOL, Dishevelled-2, PHOSPHATE ION
著者	Appleton, B.A, Wiesmann, C.
登録日	2008-02-23
公開日	2009-03-03
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (1.38 Å)
主引用文献	Inhibition of Wnt signaling by Dishevelled PDZ peptides Nat.Chem.Biol., 5, 2009

3CC0

The Dvl2 PDZ Domain in Complex with the N3 Inhibitory Peptide
分子名称:	Dishevelled-2
著者	Appleton, B.A, Wiesmann, C.
登録日	2008-02-23
公開日	2009-03-03
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (1.75 Å)
主引用文献	Inhibition of Wnt signaling by Dishevelled PDZ peptides Nat.Chem.Biol., 5, 2009

4Q2O

PDLIM4 PDZ in Complex with a Phage-Derived Peptide
分子名称:	PDZ and LIM domain protein 4
著者	Appleton, B.A, Wiesmann, C.
登録日	2014-04-09
公開日	2014-09-10
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	A structural portrait of the PDZ domain family. J.Mol.Biol., 426, 2014

4Q2Q

ZO1 PDZ3 in Complex with a Phage-Derived Peptide
分子名称:	Tight junction protein ZO-1
著者	Appleton, B.A, Wiesmann, C.
登録日	2014-04-09
公開日	2014-09-10
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (1.45 Å)
主引用文献	A structural portrait of the PDZ domain family. J.Mol.Biol., 426, 2014

4Q2P

NHERF3 PDZ2 in Complex with a Phage-Derived Peptide
分子名称:	1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Na(+)/H(+) exchange regulatory cofactor NHE-RF3
著者	Appleton, B.A, Wiesmann, C.
登録日	2014-04-09
公開日	2014-09-10
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.05 Å)
主引用文献	A structural portrait of the PDZ domain family. J.Mol.Biol., 426, 2014

4Q2N

INADL PDZ3 in Complex with a Phage-Derived Peptide
分子名称:	1,2-ETHANEDIOL, InaD-like protein
著者	Appleton, B.A, Wiesmann, C.
登録日	2014-04-09
公開日	2014-09-10
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	A structural portrait of the PDZ domain family. J.Mol.Biol., 426, 2014

3E4C

Procaspase-1 zymogen domain crystal structure
分子名称:	Caspase-1, MAGNESIUM ION
著者	Elliott, J.M, Rouge, L, Wiesmann, C, Scheer, J.M.
登録日	2008-08-11
公開日	2008-12-30
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (2.05 Å)
主引用文献	Crystal structure of procaspase-1 zymogen domain reveals insight into inflammatory caspase autoactivation J.Biol.Chem., 284, 2009

2QQO

Crystal Structure of the a2b1b2 Domains from Human Neuropilin-2
分子名称:	1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ...
著者	Appleton, B.A, Wiesmann, C.
登録日	2007-07-26
公開日	2007-11-20
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding Embo J., 26, 2007

2QQK

Neuropilin-2 a1a2b1b2 Domains in Complex with a Semaphorin-Blocking Fab
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Heavy Chain, Antibody Light Chain, ...
著者	Appleton, B.A, Wiesmann, C.
登録日	2007-07-26
公開日	2007-11-20
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (2.75 Å)
主引用文献	Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding Embo J., 26, 2007

2QQI

Crystal Structure of the b1b2 Domains from Human Neuropilin-1
分子名称:	GLYCEROL, Neuropilin-1
著者	Appleton, B.A, Desmarais, W, Wiesmann, C.
登録日	2007-07-26
公開日	2007-11-20
最終更新日	2024-10-09
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding Embo J., 26, 2007

3P9W

Crystal structure of an engineered human autonomous VH Domain in complex with VEGF
分子名称:	Vascular endothelial growth factor A, human VEGF
著者	Ma, X, Wiesmann, C.
登録日	2010-10-18
公開日	2012-04-18
最終更新日	2024-10-16
実験手法	X-RAY DIFFRACTION (2.41 Å)
主引用文献	Design of Synthetic Autonomous VH Domain Libraries and Structural Analysis of a VH Domain Bound to Vascular Endothelial Growth Factor. J.Mol.Biol., 425, 2013

2QQL

Neuropilin-2 a1a2b1b2 Domains in Complex with a Semaphorin-Blocking Fab
分子名称:	Antibody Heavy Chain, Antibody Light Chain, Neuropilin-2
著者	Appleton, B.A, Wiesmann, C.
登録日	2007-07-26
公開日	2007-11-20
最終更新日	2024-10-16
実験手法	X-RAY DIFFRACTION (3.1 Å)
主引用文献	Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding Embo J., 26, 2007

2QQJ

Crystal Structure of the b1b2 Domains from Human Neuropilin-2
分子名称:	GLYCEROL, Neuropilin-2
著者	Appleton, B.A, Wiesmann, C.
登録日	2007-07-26
公開日	2007-11-20
最終更新日	2024-10-30
実験手法	X-RAY DIFFRACTION (1.95 Å)
主引用文献	Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding Embo J., 26, 2007

3S1B

The Development of Peptide-based Tools for the Analysis of Angiogenesis
分子名称:	Vascular endothelial growth factor A, mini-Z
著者	Murray, J.M, Wiesmann, C.
登録日	2011-05-14
公開日	2011-08-17
実験手法	X-RAY DIFFRACTION (2.9 Å)
主引用文献	The development of Peptide-based tools for the analysis of angiogenesis. Chem.Biol., 18, 2011

2QQM

Crystal Structure of the a2b1b2 Domains from Human Neuropilin-1
分子名称:	1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者	Appleton, B.A, Wiesmann, C.
登録日	2007-07-26
公開日	2007-11-20
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding Embo J., 26, 2007

2QQN

Neuropilin-1 b1 Domain in Complex with a VEGF-Blocking Fab
分子名称:	1,2-ETHANEDIOL, Antibody heavy chain, Antibody light chain, ...
著者	Appleton, B.A, Wiesmann, C.
登録日	2007-07-26
公開日	2007-11-20
最終更新日	2024-10-16
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding Embo J., 26, 2007

3S1K

The Development of Peptide-based Tools for the Analysis of Angiogenesis
分子名称:	Vascular endothelial growth factor A, Z-domain
著者	Murray, J.M, Wiesmann, C.
登録日	2011-05-15
公開日	2011-08-17
最終更新日	2024-10-30
実験手法	X-RAY DIFFRACTION (2.55 Å)
主引用文献	The development of Peptide-based tools for the analysis of angiogenesis. Chem.Biol., 18, 2011

1SHM

Convergent solutions to VHH domain stabilization from natural and in vitro evolution
分子名称:	ANTIBODY RIG
著者	Bond, C.J, Wiesmann, C, Marsters, J.C, Sidhu, S.S.
登録日	2004-02-26
公開日	2005-03-08
最終更新日	2023-08-23
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	A structure-based database of antibody variable domain diversity. J.Mol.Biol., 348, 2005

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