8QXA
 
 | | TDP-43 amyloid fibrils: Morphology-1b | | 分子名称: | TAR DNA-binding protein 43 | | 著者 | Sharma, K, Shenoy, J, Loquet, A, Schmidt, M, Faendrich, M. | | 登録日 | 2023-10-24 | | 公開日 | 2024-01-24 | | 実験手法 | ELECTRON MICROSCOPY (4.05 Å) | | 主引用文献 | Cryo-EM observation of the amyloid key structure of polymorphic TDP-43 amyloid fibrils.
Nat Commun, 15, 2024
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3IQX
 | | ADP complex of C.therm. Get3 in closed form | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Tail-anchored protein targeting factor Get3, ... | | 著者 | Bozkurt, G, Wild, K, Sinning, I. | | 登録日 | 2009-08-21 | | 公開日 | 2009-12-15 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Structural insights into tail-anchored protein binding and membrane insertion by Get3.
Proc.Natl.Acad.Sci.USA, 106, 2009
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3IQW
 | | AMPPNP complex of C. therm. Get3 | | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Tail-anchored protein targeting factor Get3, ... | | 著者 | Bozkurt, G, Wild, K, Sinning, I. | | 登録日 | 2009-08-21 | | 公開日 | 2009-12-15 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural insights into tail-anchored protein binding and membrane insertion by Get3.
Proc.Natl.Acad.Sci.USA, 106, 2009
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3LPZ
 | | Crystal structure of C. therm. Get4 | | 分子名称: | Uncharacterized protein | | 著者 | Bozkurt, G, Wild, K, Sinning, I. | | 登録日 | 2010-02-08 | | 公開日 | 2010-03-16 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | The structure of Get4 reveals an alpha-solenoid fold adapted for multiple interactions in tail-anchored protein biogenesis.
Febs Lett., 584, 2010
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2RD0
 | | Structure of a human p110alpha/p85alpha complex | | 分子名称: | Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | 著者 | Huang, C, Gabelli, S.B, Amzel, L.M. | | 登録日 | 2007-09-20 | | 公開日 | 2007-12-25 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations.
Science, 318, 2007
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4PVK
 | | Phl p 4 I153V N158H variant, a glucose oxidase | | 分子名称: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, MALONATE ION, ... | | 著者 | Zafred, D, Teufelberger, A, Keller, W, Macheroux, P. | | 登録日 | 2014-03-17 | | 公開日 | 2014-04-02 | | 最終更新日 | 2015-09-02 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Rationally engineered flavin-dependent oxidase reveals steric control of dioxygen reduction.
Febs J., 282, 2015
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4PVH
 | | Phl p 4 N158H variant, a glucose dehydrogenase | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, MALONATE ION, Pollen allergen Phl p 4.0202, ... | | 著者 | Zafred, D, Teufelberger, A, Keller, W, Macheroux, P. | | 登録日 | 2014-03-17 | | 公開日 | 2014-04-02 | | 最終更新日 | 2015-09-02 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Rationally engineered flavin-dependent oxidase reveals steric control of dioxygen reduction.
Febs J., 282, 2015
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4PWB
 | | Phl p 4 I153V variant, a glucose oxidase, pressurized with Xenon | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, MALONATE ION, Pollen allergen Phl p 4.0202, ... | | 著者 | Zafred, D, Keller, W, Macheroux, P. | | 登録日 | 2014-03-19 | | 公開日 | 2014-04-02 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Rationally engineered flavin-dependent oxidase reveals steric control of dioxygen reduction.
Febs J., 282, 2015
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4PVE
 | | Wild-type Phl p 4.0202, a glucose dehydrogenase | | 分子名称: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, MALONATE ION, ... | | 著者 | Zafred, D, Teufelberger, A, Keller, W, Macheroux, P. | | 登録日 | 2014-03-17 | | 公開日 | 2014-04-02 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Rationally engineered flavin-dependent oxidase reveals steric control of dioxygen reduction.
Febs J., 282, 2015
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4PWC
 | | Phl p 4 I153V N158H variant, a glucose oxidase, 3.5 M NaBr soak | | 分子名称: | BROMIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, Pollen allergen Phl p 4.0202, ... | | 著者 | Zafred, D, Keller, W, Macheroux, P. | | 登録日 | 2014-03-19 | | 公開日 | 2014-04-02 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Rationally engineered flavin-dependent oxidase reveals steric control of dioxygen reduction.
Febs J., 282, 2015
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4PVJ
 | | Phl p 4 I153V variant, a glucose oxidase | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, MALONATE ION, Pollen allergen Phl p 4.0202, ... | | 著者 | Zafred, D, Teufelberger, A, Keller, W, Macheroux, P. | | 登録日 | 2014-03-17 | | 公開日 | 2014-04-02 | | 最終更新日 | 2015-09-02 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Rationally engineered flavin-dependent oxidase reveals steric control of dioxygen reduction.
Febs J., 282, 2015
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1TUP
 | | TUMOR SUPPRESSOR P53 COMPLEXED WITH DNA | | 分子名称: | DNA (5'-D(*AP*TP*AP*AP*TP*TP*GP*GP*GP*CP*AP*AP*GP*TP*CP*TP*A P*GP*GP*AP*A)-3'), DNA (5'-D(*TP*TP*TP*CP*CP*TP*AP*GP*AP*CP*TP*TP*GP*CP*CP*CP*A P*AP*TP*TP*A)-3'), PROTEIN (P53 TUMOR SUPPRESSOR ), ... | | 著者 | Cho, Y, Gorina, S, Jeffrey, P.D, Pavletich, N.P. | | 登録日 | 1995-07-11 | | 公開日 | 1995-07-11 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations.
Science, 265, 1994
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1RQC
 | | Crystals of peptide deformylase from Plasmodium falciparum with ten subunits per asymmetric unit reveal critical characteristics of the active site for drug design | | 分子名称: | COBALT (II) ION, formylmethionine deformylase | | 著者 | Robien, M.A, Nguyen, K.T, Kumar, A, Hirsh, I, Turley, S, Pei, D, Hol, W.G. | | 登録日 | 2003-12-04 | | 公開日 | 2004-01-20 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | An improved crystal form of Plasmodium falciparum peptide deformylase
Protein Sci., 13, 2004
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8DVG
 | | Structure of KRAS WT(7-16)-HLA-A*03:01 | | 分子名称: | Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, HLA class I histocompatibility antigen, ... | | 著者 | Wright, K.M, Miller, M, Gabelli, S.B. | | 登録日 | 2022-07-28 | | 公開日 | 2023-07-19 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.594 Å) | | 主引用文献 | Hydrophobic interactions dominate the recognition of a KRAS G12V neoantigen.
Nat Commun, 14, 2023
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7KGU
 | | Structure of 2Q1-Fab, an antibody selective for IDH2R140Q-HLA-B*07:02 | | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Miller, M.S, Aytenfisu, T.Y, Wright, K.M, Gabelli, S.B. | | 登録日 | 2020-10-18 | | 公開日 | 2021-06-23 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens.
Nat Commun, 12, 2021
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7STF
 | | Structure of KRAS G12V/HLA-A*03:01 in complex with antibody fragment V2 | | 分子名称: | Beta-2-microglobulin, HLA class I histocompatibility antigen, A alpha chain, ... | | 著者 | Wright, K.M, Gabelli, S.B, Miller, M. | | 登録日 | 2021-11-12 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-10-25 | | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | | 主引用文献 | Hydrophobic interactions dominate the recognition of a KRAS G12V neoantigen.
Nat Commun, 14, 2023
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5T7F
 | | PI3Kdelta in complex with the inhibitor GS-643624 | | 分子名称: | 2,4-bis(azanyl)-6-[[(1~{S})-1-[5-chloranyl-3-(5-fluoranyl-4-methyl-pyridin-3-yl)-4-oxidanylidene-quinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrile, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | | 著者 | Somoza, J.R, Villasenor, A. | | 登録日 | 2016-09-04 | | 公開日 | 2016-12-28 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The Discovery of GS-9901: A Potent, Selective and Metabolically Stable Inhibitor of PI3Kd
To Be Published
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5T8I
 | | PI3Kdelta in complex with the inhibitor GS-9901 | | 分子名称: | 2,4-diamino-6-{[(S)-[5-chloro-8-fluoro-4-oxo-3-(pyridin-3-yl)-3,4-dihydroquinazolin-2-yl](cyclopropyl)methyl]amino}pyrimidine-5-carbonitrile, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | | 著者 | Somoza, J.R, Villasenor, A. | | 登録日 | 2016-09-07 | | 公開日 | 2016-12-28 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The Discovery of GS-9901: A Potent, Selective and Metabolically Stable Inhibitor of PI3Kd
To Be Published
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