7KGU

Structure of 2Q1-Fab, an antibody selective for IDH2R140Q-HLA-B*07:02

Summary for 7KGU

• Entry DOI: 10.2210/pdb7kgu/pdb
• Related: 6UJ7 6UJ8 6UJ9
• Descriptor: Light Chain, Fab fragment, IGG, Heavy Chain, Fab, IGG, Fab, DI(HYDROXYETHYL)ETHER, ... (10 entities in total)
• Functional Keywords: antibody, fab, 2q1, igg, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 191724.21

Authors

Miller, M.S.,Aytenfisu, T.Y.,Wright, K.M.,Gabelli, S.B. (deposition date: 2020-10-18, release date: 2021-06-23, Last modification date: 2023-10-18)

• Primary citation: Hwang, M.S.,Miller, M.S.,Thirawatananond, P.,Douglass, J.,Wright, K.M.,Hsiue, E.H.,Mog, B.J.,Aytenfisu, T.Y.,Murphy, M.B.,Aitana Azurmendi, P.,Skora, A.D.,Pearlman, A.H.,Paul, S.,DiNapoli, S.R.,Konig, M.F.,Bettegowda, C.,Pardoll, D.M.,Papadopoulos, N.,Kinzler, K.W.,Vogelstein, B.,Zhou, S.,Gabelli, S.B.; Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens.; Nat Commun, 12:5271-5271, 2021; PubMed: 34489470; DOI: 10.1038/s41467-021-25605-4

Experimental method

X-RAY DIFFRACTION (2.4 Å)