6UJ9
Crystal structure of HLA-B*07:02 with R140Q mutant IDH2 peptide in complex with Fab
Summary for 6UJ9
Entry DOI | 10.2210/pdb6uj9/pdb |
Descriptor | HLA class I histocompatibility antigen, B-7 alpha chain, Beta-2-microglobulin, Isocitrate dehydrogenase [NADP], mitochondrial, ... (9 entities in total) |
Functional Keywords | hla-b7, mhc-i, immunotherapy, idh2, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 5 |
Total formula weight | 97767.39 |
Authors | Miller, M.S.,Thirawatananond, P.,Aytenfisu, T.Y.,Wright, K.,Gabelli, S.B. (deposition date: 2019-10-02, release date: 2021-05-05, Last modification date: 2023-10-11) |
Primary citation | Hwang, M.S.,Miller, M.S.,Thirawatananond, P.,Douglass, J.,Wright, K.M.,Hsiue, E.H.,Mog, B.J.,Aytenfisu, T.Y.,Murphy, M.B.,Aitana Azurmendi, P.,Skora, A.D.,Pearlman, A.H.,Paul, S.,DiNapoli, S.R.,Konig, M.F.,Bettegowda, C.,Pardoll, D.M.,Papadopoulos, N.,Kinzler, K.W.,Vogelstein, B.,Zhou, S.,Gabelli, S.B. Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens. Nat Commun, 12:5271-5271, 2021 Cited by PubMed: 34489470DOI: 10.1038/s41467-021-25605-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
Download full validation report