6UJ9

Crystal structure of HLA-B*07:02 with R140Q mutant IDH2 peptide in complex with Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	HLA class I histocompatibility antigen, B-7 alpha chain	polymer	298	34609.0	1	UniProt (P01889) Pfam (PF00129) Pfam (PF07654)	Homo sapiens (Human)	MHC class I antigen B*7
2	B (B)	Beta-2-microglobulin	polymer	119	13732.5	1	UniProt (P61769) Pfam (PF07654)	Homo sapiens (Human)
3	C (C)	Isocitrate dehydrogenase [NADP], mitochondrial	polymer	10	1056.2	1	UniProt (P48735)	Homo sapiens	IDH,ICD-M,IDP,NADP(+)-specific ICDH,Oxalosuccinate decarboxylase
4	D (L)	Fab light chain	polymer	214	23449.0	1		Homo sapiens (Human)
5	E (H)	Fab heavy chain	polymer	218	23308.1	1		Homo sapiens (Human)
6	F, G, H, O, Q... (A, B, L)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	6	Chemie (PEG)
7	I (A)	2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID	non-polymer		207.3	1	Chemie (NHE)
8	J, K, L, M, N... (A, B, H)	SULFATE ION	non-polymer		96.1	8	Chemie (SO4)
9	U, V (C, H)	water	water		18.0	2	Chemie (HOH)

Sequence modifications

A: 1 - 280 (UniProt: P01889)

PDB	External Database	Details
Met 0	-	initiating methionine
Gly 281	-	expression tag
Ser 282	-	expression tag
Leu 283	-	expression tag
His 284	-	expression tag
His 285	-	expression tag
Ile 286	-	expression tag
Leu 287	-	expression tag
Asp 288	-	expression tag
Ala 289	-	expression tag
Gln 290	-	expression tag
Lys 291	-	expression tag
Met 292	-	expression tag
Val 293	-	expression tag
Trp 294	-	expression tag
Asn 295	-	expression tag
His 296	-	expression tag
Arg 297	-	expression tag

C: 1 - 10 (UniProt: P48735)

PDB	External Database	Details
Gln 7	Arg 140	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	96154.9
Non-Polymers*	Number of molecules	15
	Total formula weight	1612.5
All*	Total formula weight	97767.4

*Water molecules are not included.