6UJ9

Crystal structure of HLA-B*07:02 with R140Q mutant IDH2 peptide in complex with Fab

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0006955	biological_process	immune response
B	0042612	cellular_component	MHC class I protein complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue PEG A 301

Chain	Residue
A	ALA135

---

site_id	AC2
Number of Residues	2
Details	binding site for residue PEG A 302

Chain	Residue
A	GLU163
A	GLU166

---

site_id	AC3
Number of Residues	2
Details	binding site for residue PEG A 303

Chain	Residue
A	GLN141
A	ARG145

---

site_id	AC4
Number of Residues	3
Details	binding site for residue NHE A 304

Chain	Residue
A	ASP30
A	GLN32
A	ARG239

---

site_id	AC5
Number of Residues	3
Details	binding site for residue SO4 A 305

Chain	Residue
A	ARG75
A	ARG79
A	GLN72

---

site_id	AC6
Number of Residues	1
Details	binding site for residue SO4 A 306

Chain	Residue
A	GLU161

---

site_id	AC7
Number of Residues	3
Details	binding site for residue SO4 A 307

Chain	Residue
A	ASN86
A	GLN87
H	GLY54

---

site_id	AC8
Number of Residues	4
Details	binding site for residue SO4 A 308

Chain	Residue
A	ARG79
H	TYR57
H	THR58
H	TYR59

---

site_id	AC9
Number of Residues	1
Details	binding site for residue SO4 A 309

Chain	Residue
A	GLU264

---

site_id	AD1
Number of Residues	5
Details	binding site for residue PEG B 501

Chain	Residue
A	ARG6
A	PHE8
A	TYR27
A	ASP29
B	TYR83

---

site_id	AD2
Number of Residues	4
Details	binding site for residue SO4 B 502

Chain	Residue
B	ILE55
B	GLU56
B	VAL57
B	TYR86

---

site_id	AD3
Number of Residues	2
Details	binding site for residue PEG L 301

Chain	Residue
A	ARG151
L	SER52

---

site_id	AD4
Number of Residues	1
Details	binding site for residue PEG L 302

Chain	Residue
L	SER127

---

site_id	AD5
Number of Residues	4
Details	binding site for residue SO4 H 301

Chain	Residue
H	LYS30
H	TYR55
H	THR74
H	HOH401

---

site_id	AD6
Number of Residues	2
Details	binding site for residue SO4 H 302

Chain	Residue
H	TYR55
H	ASP56

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH

Chain	Residue	Details
B	TYR98-HIS104
L	TYR192-HIS198
H	TYR199-HIS205
A	TYR257-HIS263

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	174
Details	Domain: {"description":"Ig-like C1-type"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	89
Details	Region: {"description":"Alpha-1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	91
Details	Region: {"description":"Alpha-2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	91
Details	Region: {"description":"Alpha-3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Motif: {"description":"Bw6 motif","evidences":[{"source":"PubMed","id":"25480565","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25808313","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid; in form pI 5.3","evidences":[{"source":"PubMed","id":"7554280","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P33198","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---