7SVK
| |
7SVF
| |
7SVE
| |
6USS
| |
6UST
| |
8W1Q
| Aerobic crystal structure of iron-bound FlcD from Pseudomonas aeruginosa | 分子名称: | FE (II) ION, GLYCEROL, MAGNESIUM ION, ... | 著者 | Walker, M.E, Grove, T.L, Li, B, Redinbo, M.R. | 登録日 | 2024-02-17 | 公開日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Structural Basis for Methine Excision by a Heme Oxygenase-like Enzyme Acs Cent.Sci., 2024
|
|
9B9M
| |
9B9O
| Crystal structure of FlcD from Pseudomonas aeruginosa bond to iron(II) and substrate | 分子名称: | (2R)-2-{[(2Z)-2-(hydroxyimino)ethyl]sulfanyl}butanedioic acid, FE (II) ION, Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C | 著者 | Walker, M.E, Grove, T.L, Li, B, Redinbo, M.R. | 登録日 | 2024-04-02 | 公開日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | 主引用文献 | Structural Basis for Methine Excision by a Heme Oxygenase-like Enzyme Acs Cent.Sci., 2024
|
|
9B9N
| Crystal structure of FlcD from Pseudomonas aeruginosa bound to iron (II) and substrate | 分子名称: | (2R)-2-{[(2Z)-2-(hydroxyimino)ethyl]sulfanyl}butanedioic acid, FE (III) ION, Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C | 著者 | Walker, M.E, Grove, T.L, Li, B, Redinbo, M.R. | 登録日 | 2024-04-02 | 公開日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Structural Basis for Methine Excision by a Heme Oxygenase-like Enzyme Acs Cent.Sci., 2024
|
|
6NZG
| Bacteroides uniformis beta-glucuronidase 2 covalently bound to cyclophellitol-6-carboxylate aziridine | 分子名称: | (1S,2R,3S,4S,5S,6R)-2-amino-3,4,5,6-tetrahydroxycyclohexane-1-carboxylic acid, Beta-galactosidase, CALCIUM ION, ... | 著者 | Pellock, S.J, Jariwala, P.B, Redinbo, M.R. | 登録日 | 2019-02-13 | 公開日 | 2019-12-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling. Acs Chem.Biol., 15, 2020
|
|
4HOG
| Candida glabrata dihydrofolate reductase complexed with NADPH and 5-[3-(2-methoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine (UCP111H) | 分子名称: | 5-[3-(2-methoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine, CHLORIDE ION, Dihydrofolate Reductase, ... | 著者 | Paulsen, J.L, Anderson, A.C. | 登録日 | 2012-10-22 | 公開日 | 2014-03-19 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata. J.Med.Chem., 57, 2014
|
|
4HOF
| Candida albicans dihydrofolate reductase complexed with NADPH and 5-[3-(2-methoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine (UCP111H) | 分子名称: | 5-[3-(2-methoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine, Dihydrofolate reductase, GLYCEROL, ... | 著者 | Paulsen, J.L, Anderson, A.C. | 登録日 | 2012-10-22 | 公開日 | 2014-03-19 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata. J.Med.Chem., 57, 2014
|
|
4HOE
| Candida albicans dihydrofolate reductase complexed with NADPH and 5-[3-(2,5-dimethoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine (UCP111E) | 分子名称: | 5-[3-(2,5-dimethoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine, Dihydrofolate reductase, GLYCEROL, ... | 著者 | Paulsen, J.L, Anderson, A.C. | 登録日 | 2012-10-22 | 公開日 | 2014-03-19 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata. J.Med.Chem., 57, 2014
|
|
8DHL
| |
8DHV
| |
8DHE
| |
8DHW
| Treponema lecithinolyticum beta-glucuronidase in complex with a UNC4917-glucuronide conjugate | 分子名称: | 4-(4-beta-D-glucopyranuronosylpiperazin-1-yl)-2,7-bis(methylamino)pyrido[3',2':4,5]thieno[3,2-d]pyrimidine, Glycosyl hydrolase family 2, TIM barrel domain protein, ... | 著者 | Lietzan, A.D, Redinbo, M.R. | 登録日 | 2022-06-28 | 公開日 | 2023-05-17 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Microbial beta-glucuronidases drive human periodontal disease etiology. Sci Adv, 9, 2023
|
|
8E72
| Treponema lecithinolyticum beta-glucuronidase in complex with a ciprofloxacin-glucuronide conjugate | 分子名称: | 3-carboxy-1-cyclopropyl-6-fluoro-7-(4-beta-D-glucopyranuronosyl-3,4-dihydropyrazin-1(2H)-yl)-4-oxo-1,4-dihydroquinoline, Glycosyl hydrolase family 2, TIM barrel domain protein, ... | 著者 | Lietzan, A.D, Redinbo, M.R. | 登録日 | 2022-08-23 | 公開日 | 2023-06-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Microbial beta-glucuronidases drive human periodontal disease etiology. Sci Adv, 9, 2023
|
|
7KGZ
| |
8SBG
| |
8SIJ
| |
8SL7
| |
6FFF
| Human BRD2 C-terminal bromodomain with (S)-5-(1-acetyl-2-cyclopropyl-4-(2-(hydroxymethyl)benzyl)-1,2,3,4-tetrahydroquinoxalin-6-yl)pyrimidine-2-carboxamide | 分子名称: | (S)-5-(1-acetyl-2-cyclopropyl-4-(2-(hydroxymethyl)benzyl)-1,2,3,4-tetrahydroquinoxalin-6-yl)pyrimidine-2-carboxamide, 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | 著者 | Chung, C. | 登録日 | 2018-01-07 | 公開日 | 2019-01-30 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Discovery of Tetrahydroquinoxalines as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the Second Bromodomain. J.Med.Chem., 61, 2018
|
|
6FFE
| |
6FFG
| Human BRD2 C-terminal bromodomain with (S)-1-(2-cyclopropyl-4-(2-(hydroxymethyl)benzyl)-6-(1,2,3,6-tetrahydropyridin-4-yl)-3,4-dihydroquinoxalin-1(2H)-yl)ethanone | 分子名称: | (S)-1-(2-cyclopropyl-4-(2-(hydroxymethyl)benzyl)-6-(1,2,3,6-tetrahydropyridin-4-yl)-3,4-dihydroquinoxalin-1(2H)-yl)ethanone, 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | 著者 | Chung, C. | 登録日 | 2018-01-07 | 公開日 | 2019-01-30 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Discovery of Tetrahydroquinoxalines as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the Second Bromodomain. J.Med.Chem., 61, 2018
|
|