4HOG

Candida glabrata dihydrofolate reductase complexed with NADPH and 5-[3-(2-methoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine (UCP111H)

Summary for 4HOG

Entry DOI	10.2210/pdb4hog/pdb
Related	3QLR 3QLS 3QLW 4H95 4H96 4H97 4H98 4HOE 4HOF
Descriptor	Dihydrofolate Reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[3-(2-methoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine, ... (5 entities in total)
Functional Keywords	antifungal agents, candida glabrata, drug design, enzyme inhibitors, fungal proteins, structure-activity relationship, tetrahydrofolate dehydrogenase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Candida glabrata CBS 138 (yeast)
Total number of polymer chains	2
Total formula weight	55204.19
Authors	Paulsen, J.L.,Anderson, A.C. (deposition date: 2012-10-22, release date: 2014-03-19, Last modification date: 2023-09-20)
Primary citation	G-Dayanandan, N.,Paulsen, J.L.,Viswanathan, K.,Keshipeddy, S.,Lombardo, M.N.,Zhou, W.,Lamb, K.M.,Sochia, A.E.,Alverson, J.B.,Priestley, N.D.,Wright, D.L.,Anderson, A.C. Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata. J.Med.Chem., 57:2643-2656, 2014 Cited by PubMed: 24568657 DOI: 10.1021/jm401916j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation