4HOG

Candida glabrata dihydrofolate reductase complexed with NADPH and 5-[3-(2-methoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine (UCP111H)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Dihydrofolate Reductase	polymer	227	26427.3	2	UniProt (Q6FPH0) Pfam (PF00186)	Candida glabrata CBS 138 (yeast)	Strain CBS138 chromosome J complete sequence
2	C, H (A, B)	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	2	Chemie (NDP)
3	D, I (A, B)	5-[3-(2-methoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine	non-polymer		358.4	2	Chemie (18H)
4	E, F, G, J (A, B)	CHLORIDE ION	non-polymer		35.5	4	Chemie (CL)
5	K, L (A, B)	water	water		18.0	169	Chemie (HOH)

Sequence modifications

A, B: 1 - 217 (UniProt: Q6FPH0)

PDB	External Database	Details
Leu 218	-	expression tag
Glu 219	-	expression tag
His 220	-	expression tag
His 221	-	expression tag
His 222	-	expression tag
His 223	-	expression tag
His 224	-	expression tag
His 225	-	expression tag
His 226	-	expression tag
His 227	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	52854.7
Non-Polymers*	Number of molecules	8
	Total formula weight	2349.5
All*	Total formula weight	55204.2

*Water molecules are not included.