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3F7G
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BU of 3f7g by Molmil
Structure of the BIR domain from ML-IAP bound to a peptidomimetic
分子名称: 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, Baculoviral IAP repeat-containing protein 7, L-alanyl-L-valyl-N-(2,2-diphenylethyl)-L-prolinamide, ...
著者Franklin, M.C, Fairbrother, W.J, Cohen, F.
登録日2008-11-09
公開日2009-03-17
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold
J.Med.Chem., 52, 2009
3F7H
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BU of 3f7h by Molmil
Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic
分子名称: 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Baculoviral IAP repeat-containing protein 7, ...
著者Franklin, M.C, Fairbrother, W.J, Cohen, F.
登録日2008-11-09
公開日2009-03-17
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold
J.Med.Chem., 52, 2009
3GT9
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BU of 3gt9 by Molmil
Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic
分子名称: Baculoviral IAP repeat-containing 7, N-{(1S)-1-cyclohexyl-2-[(2S)-2-(4-naphthalen-1-yl-1,3-thiazol-2-yl)pyrrolidin-1-yl]-2-oxoethyl}-N~2~-methyl-L-alaninamide, ZINC ION
著者Franklin, M.C, Fairbrother, W.J, Cohen, F.
登録日2009-03-27
公開日2010-03-09
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres.
Bioorg.Med.Chem.Lett., 20, 2010
3GTA
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BU of 3gta by Molmil
Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic
分子名称: 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Baculoviral IAP repeat-containing 7, ...
著者Franklin, M.C, Fairbrother, W.J, Cohen, F.
登録日2009-03-27
公開日2010-03-09
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres.
Bioorg.Med.Chem.Lett., 20, 2010
2AEB
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BU of 2aeb by Molmil
Crystal structure of human arginase I at 1.29 A resolution and exploration of inhibition in immune response.
分子名称: 2(S)-AMINO-6-BORONOHEXANOIC ACID, Arginase 1, MANGANESE (II) ION
著者Di Costanzo, L, Sabio, G, Mora, A, Rodriguez, P.C, Ochoa, A.C, Centeno, F, Christianson, D.W.
登録日2005-07-21
公開日2005-09-06
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.29 Å)
主引用文献Crystal structure of human arginase I at 1.29 A resolution and exploration of inhibition in the immune response.
Proc.Natl.Acad.Sci.Usa, 102, 2005
2I3H
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BU of 2i3h by Molmil
Structure of an ML-IAP/XIAP chimera bound to a 4-mer peptide (AVPW)
分子名称: 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, AVPW peptide, ...
著者Fairbrother, W.J, Franklin, M.C.
登録日2006-08-18
公開日2006-09-19
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.
Acs Chem.Biol., 1, 2006
2I3I
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BU of 2i3i by Molmil
Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic
分子名称: (3R,6R,9AR)-2,2-DIMETHYL-6-[(N-METHYL-L-ALANYL)AMINO]-N-(3-METHYL-1-PHENYL-1H-PYRAZOL-5-YL)-5-OXO-2,3,5,6,9,9A-HEXAHYDRO[1,3]THIAZOLO[3,2-A]AZEPINE-3-CARBOXAMIDE, 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
著者Fairbrother, W.J, Franklin, M.C.
登録日2006-08-18
公開日2006-09-19
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.
Acs Chem.Biol., 1, 2006
1WVA
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BU of 1wva by Molmil
Crystal structure of human arginase I from twinned crystal
分子名称: Arginase 1, MANGANESE (II) ION, S-2-(BORONOETHYL)-L-CYSTEINE
著者Di Costanzo, L, Sabio, G, Mora, A, Rodriguez, P.C, Ochoa, A.C, Centeno, F, Christianson, D.W.
登録日2004-12-14
公開日2005-09-06
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Crystal structure of human arginase I at 1.29 A resolution and exploration of inhibition in the immune response
Proc.Natl.Acad.Sci.Usa, 102, 2005
1HJR
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BU of 1hjr by Molmil
ATOMIC STRUCTURE OF THE RUVC RESOLVASE: A HOLLIDAY JUNCTION-SPECIFIC ENDONUCLEASE FROM E. COLI
分子名称: HOLLIDAY JUNCTION RESOLVASE (RUVC)
著者Ariyoshi, M, Vassylyev, D.G, Morikawa, K.
登録日1994-12-02
公開日1995-02-07
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Atomic structure of the RuvC resolvase: a holliday junction-specific endonuclease from E. coli.
Cell(Cambridge,Mass.), 78, 1994
1HQC
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BU of 1hqc by Molmil
STRUCTURE OF RUVB FROM THERMUS THERMOPHILUS HB8
分子名称: ADENINE, MAGNESIUM ION, RUVB
著者Yamada, K, Kunishima, N, Mayanagi, K, Iwasaki, H, Morikawa, K.
登録日2000-12-15
公開日2001-02-21
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Crystal structure of the Holliday junction migration motor protein RuvB from Thermus thermophilus HB8.
Proc.Natl.Acad.Sci.USA, 98, 2001
8ZD6
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BU of 8zd6 by Molmil
Crystal structure of E40K variant of Cu/Zn-superoxide dismutase from dog (Canis familiaris) in the apo form complexed with 22E1 Fv-clasp
分子名称: 22E1VH-SARAH, 22E1VL-SARAH, Superoxide dismutase [Cu-Zn]
著者Shino, Y, Furukawa, Y, Muraki, N.
登録日2024-05-01
公開日2024-11-27
最終更新日2024-12-04
実験手法X-RAY DIFFRACTION (3.29 Å)
主引用文献Disulfide-mediated oligomerization of mutant Cu/Zn-superoxide dismutase associated with canine degenerative myelopathy.
Protein Sci., 33, 2024
8ZD5
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BU of 8zd5 by Molmil
Crystal structure of E40K variant of Cu/Zn-superoxide dismutase from dog (Canis familiaris) in the holo form complexed with 22E1 Fv-clasp
分子名称: 22E1VH-SARAH, 22E1VL-SARAH, COPPER (II) ION, ...
著者Shino, Y, Furukawa, Y, Muraki, N.
登録日2024-05-01
公開日2024-11-27
最終更新日2024-12-04
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Disulfide-mediated oligomerization of mutant Cu/Zn-superoxide dismutase associated with canine degenerative myelopathy.
Protein Sci., 33, 2024
5T8E
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BU of 5t8e by Molmil
Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part II: Optimization of 4-(pyrrolidin-1-yl)benzonitrile derivatives
分子名称: 2-chloro-4-[(2S,3S)-3-hydroxy-2-methylpyrrolidin-1-yl]-3-methylbenzonitrile, Androgen receptor, GLYCEROL
著者Wilson, K.P.
登録日2016-09-07
公開日2017-04-26
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part II: Optimization of 4-(pyrrolidin-1-yl)benzonitrile derivatives.
Bioorg. Med. Chem. Lett., 27, 2017
5T8J
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BU of 5t8j by Molmil
Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part II: Optimization of 4-(pyrrolidin-1-yl)benzonitrile derivatives
分子名称: 2-fluoro-4-[(2S,3S)-3-hydroxy-2,3-dimethylpyrrolidin-1-yl]-3-methylbenzonitrile, Androgen receptor, GLYCEROL
著者Wilson, K.P.
登録日2016-09-07
公開日2017-04-26
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part II: Optimization of 4-(pyrrolidin-1-yl)benzonitrile derivatives.
Bioorg. Med. Chem. Lett., 27, 2017
5B7V
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BU of 5b7v by Molmil
Human FGFR1 kinase in complex with CH5183284
分子名称: Fibroblast growth factor receptor 1, SULFATE ION, [5-amino-1-(2-methyl-1H-benzimidazol-6-yl)-1H-pyrazol-4-yl](1H-indol-2-yl)methanone
著者Fukami, T.A, Lukacs, C.M, Janson, C.
登録日2016-06-09
公開日2016-06-22
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitor
Mol.Cancer Ther., 13, 2014
5XA4
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BU of 5xa4 by Molmil
Crystal Structure of HasAp with Fe-5,15-Diazaporphyrin
分子名称: 10,20-Diphenyl-5,15-diaza-porphyrin containing FE, Heme acquisition protein HasAp
著者Shoji, O, Uehara, H, Sugimoto, H, Shiro, Y, Watanabe, Y.
登録日2017-03-10
公開日2017-12-06
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Structures of the Heme Acquisition Protein HasA with Iron(III)-5,15-Diphenylporphyrin and Derivatives Thereof as an Artificial Prosthetic Group
Angew. Chem. Int. Ed. Engl., 56, 2017
5XIC
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BU of 5xic by Molmil
Crystal Structure of HasAp with Fe-5,10,15-triphenylporphyrin
分子名称: 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, 5,10,15-Triphenylporphyrin cpntaining FE, Heme acquisition protein HasAp
著者Shoji, O, Uehara, H, Sugimoto, H, Shiro, Y, Watanabe, Y.
登録日2017-04-26
公開日2017-12-06
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structures of the Heme Acquisition Protein HasA with Iron(III)-5,15-Diphenylporphyrin and Derivatives Thereof as an Artificial Prosthetic Group
Angew. Chem. Int. Ed. Engl., 56, 2017
5XKB
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BU of 5xkb by Molmil
Crystal Structure of HasAp with Fe-5,15-bisethynyl-10,20-diphenylporphyrin
分子名称: 5,15-Bisethynyl-10,20-diphenylporphyrin containing FE, Heme acquisition protein HasAp
著者Shoji, O, Uehara, H, Sugimoto, H, Shiro, Y, Watanabe, Y.
登録日2017-05-06
公開日2017-12-06
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structures of the Heme Acquisition Protein HasA with Iron(III)-5,15-Diphenylporphyrin and Derivatives Thereof as an Artificial Prosthetic Group
Angew. Chem. Int. Ed. Engl., 56, 2017
5XIB
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BU of 5xib by Molmil
Crystal Structure of HasAp with Fe-5,15-Diphenylporphyrin
分子名称: 5,15-Diphenylporphyrin containing FE, Heme acquisition protein HasAp
著者Shoji, O, Uehara, H, Sugimoto, H, Shiro, Y, Watanabe, Y.
登録日2017-04-26
公開日2017-12-06
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structures of the Heme Acquisition Protein HasA with Iron(III)-5,15-Diphenylporphyrin and Derivatives Thereof as an Artificial Prosthetic Group
Angew. Chem. Int. Ed. Engl., 56, 2017
5XIE
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BU of 5xie by Molmil
Crystal Structure of HasAp with 5-ethynyl-10,20-diphenylporphyrin
分子名称: 5-Ethynyl-10,20-diphenylporphyrin containing FE, Heme acquisition protein HasAp
著者Shoji, O, Uehara, H, Sugimoto, H, Shiro, Y, Watanabe, Y.
登録日2017-04-26
公開日2017-12-06
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structures of the Heme Acquisition Protein HasA with Iron(III)-5,15-Diphenylporphyrin and Derivatives Thereof as an Artificial Prosthetic Group
Angew. Chem. Int. Ed. Engl., 56, 2017
7WZ8
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BU of 7wz8 by Molmil
Structure of human langerin complex in Birbeck granules
分子名称: SNAP-tag,C-type lectin domain family 4 member K
著者Oda, T, Yanagisawa, H.
登録日2022-02-17
公開日2022-06-22
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (6.4 Å)
主引用文献Cryo-electron tomography of Birbeck granules reveals the molecular mechanism of langerin lattice formation.
Elife, 11, 2022
6XOX
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BU of 6xox by Molmil
cryo-EM of human GLP-1R bound to non-peptide agonist LY3502970
分子名称: 3-[(1S,2S)-1-(5-[(4S)-2,2-dimethyloxan-4-yl]-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl)-2-methylcyclopropyl]-1,2,4-oxadiazol-5(4H)-one, Alpha subunit of Gs with N-terminus swapped with equivalent residues in Gi,Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas, Glucagon-like peptide 1 receptor, ...
著者Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S.
登録日2020-07-07
公開日2020-11-18
最終更新日2024-11-13
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist.
Proc.Natl.Acad.Sci.USA, 117, 2020
2E2F
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BU of 2e2f by Molmil
Solution structure of DSP
分子名称: Diapausin
著者Kouno, T, Mizuguchi, M, Suzuki, K, Kawano, K.
登録日2006-11-12
公開日2007-11-13
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献The structure of a novel insect peptide explains its Ca2+ channel blocking and antifungal activities
Biochemistry, 46, 2007
1WDL
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BU of 1wdl by Molmil
fatty acid beta-oxidation multienzyme complex from Pseudomonas fragi, form II (native4)
分子名称: 3,6,9,12,15-PENTAOXATRICOSAN-1-OL, 3-ketoacyl-CoA thiolase, ACETYL COENZYME *A, ...
著者Ishikawa, M, Tsuchiya, D, Oyama, T, Tsunaka, Y, Morikawa, K.
登録日2004-05-17
公開日2004-07-27
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Structural basis for channelling mechanism of a fatty acid beta-oxidation multienzyme complex
Embo J., 23, 2004
1WDK
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BU of 1wdk by Molmil
fatty acid beta-oxidation multienzyme complex from Pseudomonas fragi, form I (native2)
分子名称: 3,6,9,12,15-PENTAOXATRICOSAN-1-OL, 3-ketoacyl-CoA thiolase, ACETYL COENZYME *A, ...
著者Ishikawa, M, Tsuchiya, D, Oyama, T, Tsunaka, Y, Morikawa, K.
登録日2004-05-17
公開日2004-07-27
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for channelling mechanism of a fatty acid beta-oxidation multienzyme complex
Embo J., 23, 2004

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