3F7G

Structure of the BIR domain from ML-IAP bound to a peptidomimetic

Summary for 3F7G

Entry DOI	10.2210/pdb3f7g/pdb
Related	1oxn 1oxq 1oy7 3F7H 3F7I
Descriptor	Baculoviral IAP repeat-containing protein 7, ZINC ION, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, ... (5 entities in total)
Functional Keywords	zinc binding, peptide complex, apoptosis inhibition, peptidomimetic, small molecule, drug design, apoptosis, metal-binding, nucleus, zinc-finger
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : Q96CA5
Total number of polymer chains	5
Total formula weight	79944.87
Authors	Franklin, M.C.,Fairbrother, W.J.,Cohen, F. (deposition date: 2008-11-09, release date: 2009-03-17, Last modification date: 2023-09-06)
Primary citation	Cohen, F.,Alicke, B.,Elliott, L.O.,Flygare, J.A.,Goncharov, T.,Keteltas, S.F.,Franklin, M.C.,Frankovitz, S.,Stephan, J.P.,Tsui, V.,Vucic, D.,Wong, H.,Fairbrother, W.J. Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold J.Med.Chem., 52:1723-1730, 2009 Cited by PubMed: 19228017 DOI: 10.1021/jm801450c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation