3F7I

Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic

Summary for 3F7I

Entry DOI	10.2210/pdb3f7i/pdb
Related	1tw6 2i3h 2i3i 3F7G 3F7H
Descriptor	Baculoviral IAP repeat-containing protein 7, ZINC ION, N-[(3aR,6S,6aS)-1-(N-methyl-L-alanyl-3-methyl-L-valyl)octahydrocyclopenta[b]pyrrol-6-yl]naphthalene-1-carboxamide, ... (7 entities in total)
Functional Keywords	zinc binding, peptide complex, apoptosis inhibition, peptidomimetic, small molecule, drug design, apoptosis, metal-binding, nucleus, zinc-finger
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	31383.52
Authors	Franklin, M.C.,Fairbrother, W.J.,Cohen, F. (deposition date: 2008-11-09, release date: 2009-03-17, Last modification date: 2024-04-03)
Primary citation	Cohen, F.,Alicke, B.,Elliott, L.O.,Flygare, J.A.,Goncharov, T.,Keteltas, S.F.,Franklin, M.C.,Frankovitz, S.,Stephan, J.P.,Tsui, V.,Vucic, D.,Wong, H.,Fairbrother, W.J. Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold J.Med.Chem., 52:1723-1730, 2009 Cited by PubMed: 19228017 DOI: 10.1021/jm801450c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation