3F7I
Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Baculoviral IAP repeat-containing protein 7 | polymer | 133 | 14977.6 | 2 | UniProt (Q6R308) Pfam (PF00653) UniProt (by SIFTS) (Q96CA5) In PDB | Homo sapiens (Human) | Kidney inhibitor of apoptosis protein, KIAP, Melanoma inhibitor of apoptosis protein, ML-IAP, Livin, RING finger protein 50 |
2 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
3 | A, B | N-[(3aR,6S,6aS)-1-(N-methyl-L-alanyl-3-methyl-L-valyl)octahydrocyclopenta[b]pyrrol-6-yl]naphthalene-1-carboxamide | non-polymer | 478.6 | 2 | Chemie (G13) | |||
4 | B | LITHIUM ION | non-polymer | 6.9 | 1 | Chemie (LI) | |||
5 | B | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 209.2 | 1 | Chemie (BTB) | |||
6 | B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
7 | water | water | 18.0 | 198 | Chemie (HOH) |
Sequence modifications
A, B: 63 - 172 (UniProt: Q6R308)
PDB | External Database | Details |
---|---|---|
Met 40 | - | expression tag |
Gly 41 | - | expression tag |
Ser 42 | - | expression tag |
Ser 43 | - | expression tag |
His 44 | - | expression tag |
His 45 | - | expression tag |
His 46 | - | expression tag |
His 47 | - | expression tag |
His 48 | - | expression tag |
His 49 | - | expression tag |
Ser 50 | - | expression tag |
Ser 51 | - | expression tag |
Gly 52 | - | expression tag |
Glu 53 | - | expression tag |
Val 54 | - | expression tag |
Pro 55 | - | expression tag |
Arg 56 | - | expression tag |
Gly 57 | - | expression tag |
Ser 58 | - | expression tag |
His 59 | - | expression tag |
Met 60 | - | expression tag |
Leu 61 | - | expression tag |
Glu 62 | - | expression tag |
Gly 150 | Ser 150 | engineered mutation |
Gln 160 | Arg 160 | engineered mutation |
Glu 161 | Asp 161 | engineered mutation |
Tyr 162 | Phe 162 | engineered mutation |
Ile 163 | Val 163 | engineered mutation |
Asn 164 | His 164 | engineered mutation |
Asn 165 | Ser 165 | engineered mutation |
Ile 166 | Val 166 | engineered mutation |
His 167 | Gln 167 | engineered mutation |
Leu 168 | Glu 168 | engineered mutation |
Leu 172 | Gln 172 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 29955.1 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1428.4 | |
All* | Total formula weight | 31383.5 |