3GT9
Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic
Summary for 3GT9
Entry DOI | 10.2210/pdb3gt9/pdb |
Related | 1TW6 2I3H 2I3I 3F7G 3F7H 3F7I 3GTA |
Descriptor | Baculoviral IAP repeat-containing 7, ZINC ION, N-{(1S)-1-cyclohexyl-2-[(2S)-2-(4-naphthalen-1-yl-1,3-thiazol-2-yl)pyrrolidin-1-yl]-2-oxoethyl}-N~2~-methyl-L-alaninamide, ... (4 entities in total) |
Functional Keywords | zinc binding, peptide complex, apoptosis inhibition, peptidomimetic, small molecule, drug design, apoptosis, metal-binding |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 31095.33 |
Authors | Franklin, M.C.,Fairbrother, W.J.,Cohen, F. (deposition date: 2009-03-27, release date: 2010-03-09, Last modification date: 2024-04-03) |
Primary citation | Cohen, F.,Koehler, M.F.,Bergeron, P.,Elliott, L.O.,Flygare, J.A.,Franklin, M.C.,Gazzard, L.,Keteltas, S.F.,Lau, K.,Ly, C.Q.,Tsui, V.,Fairbrother, W.J. Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres. Bioorg.Med.Chem.Lett., 20:2229-2233, 2010 Cited by PubMed: 20189383DOI: 10.1016/j.bmcl.2010.02.021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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