3F7I
Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic
Summary for 3F7I
Entry DOI | 10.2210/pdb3f7i/pdb |
Related | 1tw6 2i3h 2i3i 3F7G 3F7H |
Descriptor | Baculoviral IAP repeat-containing protein 7, ZINC ION, N-[(3aR,6S,6aS)-1-(N-methyl-L-alanyl-3-methyl-L-valyl)octahydrocyclopenta[b]pyrrol-6-yl]naphthalene-1-carboxamide, ... (7 entities in total) |
Functional Keywords | zinc binding, peptide complex, apoptosis inhibition, peptidomimetic, small molecule, drug design, apoptosis, metal-binding, nucleus, zinc-finger |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 31383.52 |
Authors | Franklin, M.C.,Fairbrother, W.J.,Cohen, F. (deposition date: 2008-11-09, release date: 2009-03-17, Last modification date: 2024-04-03) |
Primary citation | Cohen, F.,Alicke, B.,Elliott, L.O.,Flygare, J.A.,Goncharov, T.,Keteltas, S.F.,Franklin, M.C.,Frankovitz, S.,Stephan, J.P.,Tsui, V.,Vucic, D.,Wong, H.,Fairbrother, W.J. Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold J.Med.Chem., 52:1723-1730, 2009 Cited by PubMed: 19228017DOI: 10.1021/jm801450c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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